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11.发明申请MECHANICALLY STABLE PHARMACEUTICAL PRESENTATION FORM CONTAINING LIQUID OR SEMI-SOLID SURFACE-ACTIVE SUBSTANCES 审中-公开机械稳定的药物剂型含液体或半固体表面活性物质
公开(公告)号：WO0057854A3
公开(公告)日：2001-03-15
申请号：PCT/EP0002381
申请日：2000-03-17
Applicant: BASF AG , ROSENBERG JOERG , BERNDL GUNTHER , LIEPOLD BERND , BREITENBACH JOERG
Inventor： ROSENBERG JOERG , BERNDL GUNTHER , LIEPOLD BERND , BREITENBACH JOERG
IPC: A61K47/10 , A61K9/16 , A61K9/20 , A61K47/14 , A61K47/34 , A61P31/10 , A61P35/00 , A61P37/06 , A61P43/00
CPC classification number: A61K9/1617 , A61K9/1635 , A61K9/1694
Abstract: The invention relates to mechanically stable pharmaceutical presentation forms for peroral administration which in addition to one or more active ingredients and at least one thermoplastically mouldable matrix-forming auxiliary contain more than 10 and up to 40 % by weight of a surface-active substance which has an HLB of between 2 and 18 and is liquid at 20 DEG C or has a dropping point at between 20 and 50 DEG C.
Abstract translation: 使用涉及机械稳定的药物剂型经口给药，包括，除了一种或多种活性成分和至少一种可熔融加工的基质形成赋形剂大于10和高达40重量具有2至18的HLB值的表面活性剂的％，其中 20℃下是液体或在20〜50℃的滴点
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公开(公告)号：WO0032169A2
公开(公告)日：2000-06-08
申请号：PCT/EP9909309
申请日：1999-11-30
Applicant: BASF AG , BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
Inventor： BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
CPC classification number: B29C47/42 , A61J3/10 , A61J2200/20 , A61K9/1694 , A61K9/2095 , B29C47/0021
Abstract: The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).
Abstract translation: 本发明涉及一种通过熔体挤出制备固体剂型的方法。 在这种情况下，混合的聚合物粘合剂，至少一种药物活性成分和任选的其它添加剂，将混合物熔化到挤出机中并挤出它然后在连续塑料产物链的形式。 使用本发明的方法的特征在于，作为挤出机具有一个行星辊挤出机（10），其优选地具有一个中心轴（13）和6个行星主轴（14）。
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公开(公告)号：WO9959541A2
公开(公告)日：1999-11-25
申请号：PCT/EP9903002
申请日：1999-05-04
Applicant: BASF AG , HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
Inventor： HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
CPC classification number: A61K9/5123 , A61K9/0095 , A61K9/1617 , A61K9/1658 , A61K9/5169 , A61K38/13
Abstract: The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.
Abstract translation: 存在嵌入在涂层基质的固体或液体环孢菌素制剂用于口服给药的，其中以固体，X射线无定形的颗粒形式的环孢菌素kolloidaldispers。
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公开(公告)号：WO9927916A3
公开(公告)日：1999-08-12
申请号：PCT/EP9807716
申请日：1998-11-30
Applicant: BASF AG , KOTHRADE STEPHAN , MEFFERT HELMUT , BERNDL GUNTHER , ERNST ANDREAS , SANNER AXEL
Inventor： KOTHRADE STEPHAN , MEFFERT HELMUT , BERNDL GUNTHER , ERNST ANDREAS , SANNER AXEL
IPC: A61K47/32 , A23K20/10 , A23K40/10 , A23K40/20 , A23L27/00 , A23L33/10 , A61K9/16 , A61K9/20 , A61K9/22 , A61K31/277 , A61K31/421
CPC classification number: A61K31/421 , A23K20/10 , A23K40/10 , A23K40/20 , A23K40/25 , A23L27/74 , A23L33/10 , A23V2002/00 , A61K9/2027 , A61K9/2095 , A61K31/277 , A23V2200/21 , A23V2250/30 , A23V2250/51088 , A23V2250/5118
Abstract: The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.
Abstract translation: 本发明涉及一种用于通过将至少一种聚合物粘合剂，至少一种活性成分，并在适当的常规添加剂，以形成塑料混合物制备固体剂型，和成形，使用如聚合物粘合剂的N-乙烯基内酰胺的共聚物和可共聚的单体 与疏水性残留物一起使用。 以简单和廉价的方式，获得缓慢释放活性成分的剂型。
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公开(公告)号：CA2367020C
公开(公告)日：2008-12-16
申请号：CA2367020
申请日：2000-03-10
Applicant: BASF AG
Inventor： LEHMANN STEPHAN , SIMON DIRK , BERNDL GUNTHER , REINHOLD ULRICH
IPC: A61K9/20 , A01N25/08 , A01N25/10 , A61K8/73 , A61K8/86 , A61K9/22 , A61K31/192 , A61K31/565 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K47/48 , A61Q19/00
Abstract: The invention relates to a method for producing solid dosage forms containin g at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components . According to the method, the components are mixed and plasticised at a temperature below 220 .degree.C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.
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Patent Agency Ranking
公开(公告)号：AT344019T
公开(公告)日：2006-11-15
申请号：AT01957809
申请日：2001-05-29
Applicant: BASF AG
Inventor： BERNDL GUNTHER , BREITENBACH JOERG , HEGER ROBERT , STADLER MICHAEL , WILKE PETER , ROSENBERG JOERG
IPC: A61F13/53 , A23P1/02 , A23P1/08 , A61F13/49 , A61K9/107 , A61K9/16 , A61K47/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38
Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
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公开(公告)号：DE59909945D1
公开(公告)日：2004-08-19
申请号：DE59909945
申请日：1999-09-23
Applicant: BASF AG
Inventor： KOTHRADE STEPHAN , BERNDL GUNTHER , MEFFERT HELMUT
Abstract: The present invention relates to a solid dosage form comprising at least one polymeric binder and at least one active ingredient and, where appropriate, conventional additives, wherein the polymeric binder consists of copolymerized units a) 15-83% by weight of at least one N-vinyllactam, b) 15-83% by weight of methyl methacrylate, c) 2-70% by weight of at least one other monomer and d) 0-9.9% by weight of at least one alpha,beta-ethylenically unsaturated acid.
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公开(公告)号：DE59909717D1
公开(公告)日：2004-07-22
申请号：DE59909717
申请日：1999-03-22
Applicant: BASF AG
Inventor： KOTHRADE STEPHAN , BERNDL GUNTHER , SIMON DIRK , SANNER AXEL
Abstract: Solid dosage forms containing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives, wherein a physiologically tolerated, water-swellable graft copolymer or a mixture of graft copolymers is employed as polymeric binder.
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公开(公告)号：PT1158962E
公开(公告)日：2003-04-30
申请号：PT00916925
申请日：2000-03-10
Applicant: BASF AG
Inventor： REINHOLD ULRICH , BERNDL GUNTHER , SIMON DIRK , LEHMANN STEPHAN
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公开(公告)号：DK1158962T3
公开(公告)日：2003-01-06
申请号：DK00916925
申请日：2000-03-10
Applicant: BASF AG
Inventor： BERNDL GUNTHER , LEHMANN STEPHAN , REINHOLD ULRICH , SIMON DIRK
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