公开(公告)号：NZ283333A

公开(公告)日：1997-02-24

申请号：NZ28333395

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  C07D251/26 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D239/00 ,  C07D251/00

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：AT146526T

公开(公告)日：1997-01-15

申请号：AT92919916

申请日：1992-09-21

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

公开(公告)号：NO970161D0

公开(公告)日：1997-01-14

申请号：NO970161

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：NO964121A

公开(公告)日：1996-11-26

申请号：NO964121

申请日：1996-09-27

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：FI963885A0

公开(公告)日：1996-09-27

申请号：FI963885

申请日：1996-09-27

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：AT130872T

公开(公告)日：1995-12-15

申请号：AT91912909

申请日：1991-07-19

Applicant: BASF AG

Inventor： BACH ALFRED ,  HILLEN HEINZ ,  BIALOJAN SIEGFRIED

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57

公开(公告)号：CA2121352A1

公开(公告)日：1993-05-13

申请号：CA2121352

申请日：1992-10-27

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  KUENAST CHRISTOPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/00 ,  C07K14/245 ,  C07K14/435 ,  C07K14/81 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19 ,  A61K38/57

Abstract: 2121352 9309232 PCTABS00022 The description relates to a novel thrombin inhibiting protein from reduvii with a molecular weight of some 12000 Dalton and the N-terminus Glu-Gly-Gly-Glu-Pro-Cys-Ala-Cys-Pro-His-Ala-Leu-His-Arg-Val-Cys-Gly-Ser-Asp. The protein is useful in combatting diseases.

公开(公告)号：CA2121246A1

公开(公告)日：1993-05-13

申请号：CA2121246

申请日：1992-09-23

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  KOERWER WOLFGANG ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/14 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  A61K38/57

Abstract: 2121246 9309231 PCTABS00022 The invention relates to a novel thrombin-inhibiting protein from ticks with a molecular weight of some 26000 Dalton and which has the amino acid partial sequences Val-Ala-Lys-Phe-Ala-X-Asn-Ser-Gly-Ser-Glu-Thr-Gly, His-Ala-Y-Phe-Glu, Arg-Val-Ser-Asp-Phe-Glu and Phe-Val-Tyr-Thr-Ile-Glu, in which X and Y may be the same or different and stand for a naturally occurring amino acid. The protein is suitable for combatting diseases.

公开(公告)号：MX9206339A

公开(公告)日：1993-05-01

申请号：MX9206339

申请日：1992-11-04

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS ,  BIALOJAN SIEGFRIED ,  KROEGER BURKHARD ,  KUENAST CHRISTIPH

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/00 ,  C07K14/245 ,  C07K14/435 ,  C07K14/81 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

Abstract: PCT No. PCT/EP92/02450 Sec. 371 Date Apr. 26, 1994 Sec. 102(e) Date Apr. 26, 1994 PCT Filed Oct. 27, 1992 PCT Pub. No. WO93/09232 PCT Pub. Date May 13, 1993.A novel thrombin-inhibitory protein from assassin bugs with a molecular weight of about 12,000 dalton and the N terminus Glu-Gly-Gly-Glu-Pro-Cys-Ala-Cys-Pro-His-Ala-Leu-His-Arg-Val-Cys-Gly-Ser-Asp is described. The protein is suitable for controlling diseases.

公开(公告)号：CA2186784C

公开(公告)日：2007-02-20

申请号：CA2186784

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BOLLSCHWEILER CLAUS

IPC: A61K31/505 ,  C07D251/26 ,  A61K31/00 ,  A61K31/19 ,  A61K31/215 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention concerns the use of carboxylic acid derivatives of formula I ( I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR14, wherein R14 means hydroge n or, together with R3, forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituen ts have the meanings given in the description. These derivatives can be used fo r preparing medicaments.