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    11.
    发明专利
    未知

    公开(公告)号：DE102005062661A1

    公开(公告)日：2007-08-16

    申请号：DE102005062661

    申请日：2005-12-23

    Applicant: BASF AG

    Inventor： BREUER MICHAEL

    IPC: C07D333/16

    Abstract: A process for preparing optically active (1S)-3-chloro-1-(2-thienyl)propan-1-ol of the formula I by, in a medium comprising 3-chloro-1-(2-thienyl)propan-1-one of the formula II reducing this compound to the compound of the formula I by means of an alcohol dehydrogenase from the Thermoanaerobacter genus, and isolating the product formed in substantially enantiomerically pure form.

    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating
    14.
    发明专利
    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating 未知

    公开(公告)号：DE102005062662A1

    公开(公告)日：2007-06-28

    申请号：DE102005062662

    申请日：2005-12-23

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KESELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12N9/04 ,  C12P7/02

    Abstract: Preparation of optically active alkanol compound (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound (II) and isolating the product, where (II) is enzymatically reduced to (I). Preparation of optically active alkanol compound of formula (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound of formula Cyc-(C=O)-(CH 2) n-CH 2-R 1>(II) and isolating the product, where (II) is enzymatically reduced to (I). n : 0-5; Cyc : optionally substituted, mono- or polynuclear, (un)saturated, carbocylic or heterocyclic ring; R 1>halo, SH, OH, NO 2, NR 2>R 3> or NR 2>R 3>R 4+>X ->; R 2>-R 4>H, lower alkyl or lower alkoxy; and X ->counter ion. An independent claim is also included for the enzyme with dehydrogenase activity. [Image] ACTIVITY : Antidepressant; Uropathic. No biological data given. MECHANISM OF ACTION : None given.

    LIPASE PRODUCTION METHOD
    15.
    发明专利
    LIPASE PRODUCTION METHOD 未知

    公开(公告)号：CA2611622A1

    公开(公告)日：2006-12-21

    申请号：CA2611622

    申请日：2006-06-13

    Applicant: BASF AG

    Inventor： ROSENAU FRANK ,  JAEGER KARL-ERICH ,  BESELIN ANKE ,  HAUER BERNHARD ,  BREUER MICHAEL

    IPC: C12N9/52

    Abstract: The invention relates to novel proteins, in particular, exhibiting a proteas e activity and promoting the production of extracellular lipases by bacteria, in particular, by Burkholderia-type bacteria, to coding nucleic acid sequences, expression constructs containing them, host modified thereby, to a method fo r producing proteins exhibiting a protease activity and to a lipase production method, in particular by Burkholderia-type bacteria.

    MUTANTE DE PIRUVATODESCARBOXILASA, SU OBTENCION Y EMPLEO.
    17.
    发明专利
    MUTANTE DE PIRUVATODESCARBOXILASA, SU OBTENCION Y EMPLEO. 未知

    公开(公告)号：ES2253556T3

    公开(公告)日：2006-06-01

    申请号：ES02767395

    申请日：2002-08-16

    Applicant: BASF AG

    Inventor： BREUER MICHAEL ,  HAUER BERNHARD ,  FRIEDRICH THOMAS

    IPC: C12N9/88 ,  C12P7/26 ,  C12P41/00

    Abstract: Microcápsulas con diámetros medios comprendidos en el intervalo de 0, 1 a 5 mm que se pueden obtener (a) procesando preparados acuosos de ingredientes activos con cuerpos oleaginosos en presencia de emulsionantes para producir emulsiones aceite en agua, (b) tratando las emulsiones resultantes con soluciones acuosas de polímeros aniónicos, (c) poniendo en contacto la matriz resultante con soluciones acuosas de quitosano y (d) separando los productos de encapsulado resultantes de la fase acuosa.

    18.
    发明专利
    未知

    公开(公告)号：DE102004055508A1

    公开(公告)日：2006-06-01

    申请号：DE102004055508

    申请日：2004-11-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  HAUER BERNHARD ,  DREW DEJANA ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12P7/16

    Abstract: The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.

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