公开(公告)号：DE3808353A1

公开(公告)日：1989-09-21

申请号：DE3808353

申请日：1988-03-12

Applicant: BASF AG

Inventor： DAUM LOTHAR DR ,  DOERPER THOMAS DR ,  GEISS KARL-HEINZ DR ,  HERR DIETER DR ,  SCHLICK ERICH DR

IPC: C12N9/99 ,  A61K31/505 ,  A61K31/52 ,  A61K31/715 ,  A61K38/00 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00

公开(公告)号：DE3782549D1

公开(公告)日：1992-12-17

申请号：DE3782549

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

Abstract: (I) and their allelic variations and mutagenically produced derivs. with lymphotoxin or lymphotoxin-like activity, as well as derivs. having an N-terminal immunogenic peptide sequence, are new. (I) is X-Leu-Lys-Pro-Ala-Ala-His-Leu-Ile -Gly-Asp-Pro-Ser-Lys-Gln-Asn-Ser-Leu- Leu-Trp-Arg-Ala-Asn-Thr-Asp-Arg-Ala-Phe-Leu-Gln-Asp-Gly-Phe-Ser-L- eu-Ser-Asn-Asn-Ser-Leu-Leu -Val-Pro-Thr-Ser-Gly-Ile -Tyr-Phe-Val-Tyr-Ser-Gln- -Val-Val-Phe-Ser-Gly-Lys-Ala-Tyr-Ser-Pro-Lys-Ala-Thr- Ser-Ser-Pro-Leu Tyr-Leu-Ala-His-Glu-Val -Gln- Leu-Phe-Ser--Ser-Gln-Tyr-Pro-Phe-His-Val-Pro- Leu-Leu-Ser-Ser-Gln -Lys-Met-Val-Tyr-Pro-Gly- Leu-Gln-Glu-Pro -Trp-Leu-His-Ser-Met-Tyr-His-Gly -Ala-Ala-Phe-Gln-Leu-Thr-Gln-Gly-Asp- Gln-Leu-Ser-Thr -His-Thr-Asp-Gly-Ile-Pro-His-Leu -Val-Leu-Ser-Pro Ser-Thr-Val-Phe-Phe-Gly -Ala-Phe-Ala-Leu, where X = Thr, Ser-Thr, Met-Ser-Thr, Ala-Thr or Ala-Ser-Thr. DNA sequences coding for the polypeptides are also new.

公开(公告)号：DE3922089A1

公开(公告)日：1990-12-13

申请号：DE3922089

申请日：1989-07-05

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG DR ,  HILLEN HEINZ DR ,  MOELLER ACHIM DR ,  DAUM LOTHAR DR ,  DOERPER THOMAS DR ,  SUBKOWSKI THOMAS DR

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: Novel proteins have a molecular weight of approximately 42.000 daltons and the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu on their terminal N, where X denotes a hydrogen atom, a phenylalanine (Phe) residue or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe. These proteins have a therapeutic effect.

公开(公告)号：DE3823805A1

公开(公告)日：1990-01-18

申请号：DE3823805

申请日：1988-07-14

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  SCHWARZ MARGARETE DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: C12N9/64 ,  A61K38/46 ,  A61P7/02 ,  C12N9/72 ,  C12N15/57 ,  C12N15/58

公开(公告)号：DE3735917A1

公开(公告)日：1989-05-03

申请号：DE3735917

申请日：1987-10-23

Applicant: BASF AG

Inventor： KOERWER WOLFGANG DR ,  KURFUERST MANFRED DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR

IPC: A61K38/46 ,  A61P7/02 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91

公开(公告)号：DE3716513A1

公开(公告)日：1988-11-24

申请号：DE3716513

申请日：1987-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS DR ,  MOELLER ACHIM DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  KEILHAUER GERHARD DR ,  EMLING FRANZ DR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C07H21/04

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.