公开(公告)号：DK148940C

公开(公告)日：1986-05-05

申请号：DK257381

申请日：1981-06-12

Applicant: BASF AG

Inventor： THYES MARCO ,  KOENIG HORST ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：HU188179B

公开(公告)日：1986-03-28

申请号：HU203482

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHIILIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D401/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：CA1202305A

公开(公告)日：1986-03-25

申请号：CA394094

申请日：1982-01-13

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  STEINER GERD ,  THIEME PETER C ,  LENKE DIETER ,  GRIES JOSEF ,  TESCHENDORF HANS-JUERGEN

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61P9/02 ,  A61P11/08 ,  A61P25/08 ,  A61P25/20 ,  C07D231/12 ,  C07D231/38 ,  C07D233/60 ,  C07D233/88 ,  C07D239/42 ,  C07D261/08 ,  C07D295/06 ,  C07D295/092 ,  C07D521/00 ,  C07D295/04 ,  C07D403/12

Abstract: Novel (hetarylphenoxy) (phenylpiperazinyl)-propanols of the formula I where R1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, and the heterocyclic structure Het. is pyrimidinyl, triazol1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.

公开(公告)号：FI852730L

公开(公告)日：1986-01-13

申请号：FI852730

申请日：1985-07-10

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.

公开(公告)号：CS238636B2

公开(公告)日：1985-12-16

申请号：CS783982

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：AU548396B2

公开(公告)日：1985-12-12

申请号：AU8515382

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D401/10 ,  C07D403/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：NO152129B

公开(公告)日：1985-04-29

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75

公开(公告)号：FI844729A0

公开(公告)日：1984-11-30

申请号：FI844729

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D

公开(公告)号：DK566684D0

公开(公告)日：1984-11-29

申请号：DK566684

申请日：1984-11-29

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D

公开(公告)号：CA1175831A

公开(公告)日：1984-10-09

申请号：CA411288

申请日：1982-09-13

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C97/10 ,  C07D295/10

Abstract: Novel aninopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.