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公开(公告)号：BG64338B1
公开(公告)日：2004-10-29
申请号：BG10372899
申请日：1999-09-13
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , HAUPT ANDREAS
IPC: A61K38/00 , A61K31/337 , A61K38/07 , A61K38/08 , A61K38/15 , A61P35/00 , C07K5/08 , C07K5/10 , C07K7/00 , A61K38/04 , A61K31/335
Abstract: The invention relates to a composition and methods for cancer treatment. The compounds with formula I listed in the description are combined with paclitaxel, taxoter or modified taxane, or taxoid analogues. As a result higher anticancer effect is produced in comparison with the effect of the individual compounds.
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公开(公告)号：PL186721B1
公开(公告)日：2004-02-27
申请号：PL32717596
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：ZA200107978B
公开(公告)日：2003-03-26
申请号：ZA200107978
申请日：2001-09-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , C12N9/99 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , C07K , C07D , A61K , A61P
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：HU0203167A2
公开(公告)日：2003-02-28
申请号：HU0203167
申请日：2000-03-28
Applicant: BASF AG
Inventor： HAUPT ANDREAS , HILLEN HEINZ , KLING ANDREAS , MACK HELMUT , SCHMIDT MARTIN , SEITZ WERNER , ZECHEL JOHANN-CHRISTIAN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：CZ20013577A3
公开(公告)日：2002-07-17
申请号：CZ20013577
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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Patent Agency Ranking
公开(公告)号：AU750120B2
公开(公告)日：2002-07-11
申请号：AU8475898
申请日：1998-07-07
Applicant: BASF AG , BASF BIORES CORP
Inventor： JANSSEN BERND , BARLOZZARI TERESA , HAUPT ANDREAS , ZIERKE THOMAS , KLING ANDREAS
Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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公开(公告)号：AU748465B2
公开(公告)日：2002-06-06
申请号：AU9502498
申请日：1998-09-24
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , BANERJEE SUBHASHIS , HAUPT ANDREAS
Abstract: The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula I as defined herein alone or in combination with one or more other antiarthritic drugs provide suppression of rheumatoid arthritis.
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公开(公告)号：SK14232001A3
公开(公告)日：2002-06-04
申请号：SK14232001
申请日：2000-03-28
Applicant: BASF AG
Inventor： HILLEN HEINZ , SCHMIDT MARTIN , MACK HELMUT , SEITZ WERNER , HAUPT ANDREAS , ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS
IPC: A61K38/00 , A61K38/55 , A61P1/04 , A61P1/18 , A61P5/14 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , C12N9/99 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/02 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P37/02 , C07B43/00 , C07D401/12 , C07D409/12 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
Abstract: Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.
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公开(公告)号：HU0101715A2
公开(公告)日：2001-11-28
申请号：HU0101715
申请日：1998-09-24
Applicant: BASF AG
Inventor： BANERJEE SUBHASHIS , BARLOZZARI TERESA , HAUPT ANDREAS
Abstract: The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula I as defined herein alone or in combination with one or more other antiarthritic drugs provide suppression of rheumatoid arthritis.
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公开(公告)号：HU0004234A2
公开(公告)日：2001-05-28
申请号：HU0004234
申请日：1998-07-07
Applicant: BASF AG
Inventor： BARLOZZARI TERESA , HAUPT ANDREAS , JANSSEN BERND , KLING ANDREAS DR , ZIERKE THOMAS DR
Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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