公开(公告)号：DE10017102A1

公开(公告)日：2001-10-11

申请号：DE10017102

申请日：2000-04-06

Applicant: BASF AG

Inventor： KESSEL KNUT ,  SCHERR GUENTER ,  BOGENSTAETTER THOMAS ,  BERNDL GUNTHER ,  BREITENBACH JOERG

IPC: A61K9/20 ,  A61K31/198 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02 ,  A61P21/00 ,  C08K5/29 ,  C08L101/00 ,  A61K31/197 ,  A61K9/18

Abstract: Preparation of a solid dosage form containing creatine (I) involves: (a) forming a mixture containing at least one water-soluble or water-swellable thermoplastic binder (II), (I) and 1-20 moles of water per mole of (I); (b) heating the mixture to or above the softening point of (II); and (c) shaping the plasticized mixture into the dosage form and cooling. Independent claims are included for the following: (i) the dosage forms obtained by the above process; and (ii) dosage forms containing (I) at 3.3 mmol or more per g of the dosage form, in finely dispersed or molecular dispersion form in a matrix of (II).

公开(公告)号：AU3423197A

公开(公告)日：1998-02-26

申请号：AU3423197

申请日：1997-08-18

Applicant: BASF AG

Inventor： KESSEL KNUT ,  PATSCH MANFRED ,  HERRMANN MANFRED ,  REINER KURT ,  JESSEN JORG ,  WIESENFELDT MATTHIAS

IPC: C09B67/24 ,  C09D5/00 ,  C09D139/06 ,  C14C11/00 ,  D06P1/52 ,  D06P3/30 ,  D06P3/32 ,  D21H21/28 ,  C08K5/42 ,  C08L31/04 ,  C08L39/06 ,  C09B45/16 ,  C09B45/20

Abstract: Liquid or solid mixtures of sulphonated 1:2-metal complex dyes, which contain little salt, and poly-N-vinylpyrrolidone (PVP) or copolymers (co-PVP) of N-vinylpyrrolidone and vinyl acetate, are claimed.

公开(公告)号：CA2256379C

公开(公告)日：2008-03-18

申请号：CA2256379

申请日：1997-11-28

Applicant: BASF AG

Inventor： UHR HERMANN ,  MERGER ROLAND ,  MITULLA KONRAD ,  KESSEL KNUT ,  SCHRODER JURGEN ,  SUTORIS HEINZ FRIEDRICH

IPC: C07C7/20 ,  C07F15/02 ,  C07B63/04 ,  C07C15/46 ,  C07C51/50 ,  C07C57/075 ,  C07C67/62 ,  C07C69/15 ,  C07C69/54 ,  C07C231/22 ,  C07C233/03 ,  C07C253/32 ,  C07C255/08 ,  C07D201/18 ,  C07D207/267 ,  C07D223/10 ,  C08F2/40 ,  C08F4/00

Abstract: The invention concerns substance mixtures containing: (A) compounds containi ng vinyl groups; (B) an active amount of a mixture which inhibits premature polymerization of the compounds containing vinyl groups and contains: (i) at least one N-oxyl compound of a secondary amine which does not carry any hydrogen atoms on the .alpha.-carbo n atoms; and (ii) at least one iron compound; (C) optionally nitro compounds; and (D) optionally co-stabilizers. The invention further concerns a process for inhibiting the premature polymerization of compounds (A) containing vinyl groups, and the use of mixture (B), optionall y mixed with nitro compounds (C) and/or co-stabilizers (D), for inhibiting the premature polymerization of radically polymerizable compounds and for stabilizing organic materials against the harmful effect of radicals.

公开(公告)号：ES2207907T3

公开(公告)日：2004-06-01

申请号：ES99125660

申请日：1999-12-22

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  GREINDL THOMAS ,  BOGENSTATTER THOMAS ,  SCHERR GUNTER ,  RAULS MATTHIAS

IPC: C07C277/08 ,  C07C279/14 ,  C07C303/22 ,  C07C309/15 ,  C07F9/38

Abstract: Preparation of guanidine derivatives (I) comprises reacting O-alkylisourea salts (II) with an amine (III) in the presence of seed crystals of (I). Preparation of guanidine derivatives of formula (I) comprises reacting O-alkylisourea salts of formula (II) with an amine of formula (III) in the presence of seed crystals of (I). R1 = 1-8C alkylene or a divalent 5-10C cycloaliphatic group; R2 = H or 1-8C alkyl; or NR1R2 = 5-6 membered ring substituted by Z; Z = COOR3, SO2OR3 or PO(OR3)(OR4); R3 = H, alkalimetal or an equivalent of an alkaline earth metal; and R4 = as for R3 or 1-6C alkyl; R5 = 1-8C alkyl; X = equivalent of an anion.

公开(公告)号：DE19860048A1

公开(公告)日：2000-06-29

申请号：DE19860048

申请日：1998-12-23

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  GREINDL THOMAS ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER ,  RAULS MATTHIAS ,  GELDER RICHARD VAN

IPC: C07C277/08 ,  C07C279/14 ,  C07C303/22 ,  C07C309/15 ,  C07F9/38 ,  C07C303/30 ,  C07F9/40 ,  C07C279/16 ,  C07C309/70 ,  C07C309/71

Abstract: Preparation of guanidine derivatives (I) comprises reacting O-alkylisourea salts (II) with an amine (III) in the presence of seed crystals of (I). Preparation of guanidine derivatives of formula (I) comprises reacting O-alkylisourea salts of formula (II) with an amine of formula (III) in the presence of seed crystals of (I). R1 = 1-8C alkylene or a divalent 5-10C cycloaliphatic group; R2 = H or 1-8C alkyl; or NR1R2 = 5-6 membered ring substituted by Z; Z = COOR3, SO2OR3 or PO(OR3)(OR4); R3 = H, alkalimetal or an equivalent of an alkaline earth metal; and R4 = as for R3 or 1-6C alkyl; R5 = 1-8C alkyl; X = equivalent of an anion.

公开(公告)号：AT254100T

公开(公告)日：2003-11-15

申请号：AT00102786

申请日：2000-02-10

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER

IPC: C07C277/02 ,  C07C277/08 ,  C07C279/14

公开(公告)号：DE59906941D1

公开(公告)日：2003-10-16

申请号：DE59906941

申请日：1999-12-22

Applicant: BASF AG

Inventor： KESSEL KNUT ,  KLUGE MICHAEL ,  GREINDL THOMAS ,  BOGENSTAETTER THOMAS ,  SCHERR GUENTER ,  RAULS MATTHIAS ,  VAN GELDER RICHARD

IPC: C07C277/08 ,  C07C279/14 ,  C07C303/22 ,  C07C309/15 ,  C07F9/38

Abstract: Preparation of guanidine derivatives (I) comprises reacting O-alkylisourea salts (II) with an amine (III) in the presence of seed crystals of (I). Preparation of guanidine derivatives of formula (I) comprises reacting O-alkylisourea salts of formula (II) with an amine of formula (III) in the presence of seed crystals of (I). R1 = 1-8C alkylene or a divalent 5-10C cycloaliphatic group; R2 = H or 1-8C alkyl; or NR1R2 = 5-6 membered ring substituted by Z; Z = COOR3, SO2OR3 or PO(OR3)(OR4); R3 = H, alkalimetal or an equivalent of an alkaline earth metal; and R4 = as for R3 or 1-6C alkyl; R5 = 1-8C alkyl; X = equivalent of an anion.

公开(公告)号：DE59905818D1

公开(公告)日：2003-07-10

申请号：DE59905818

申请日：1999-11-22

Applicant: BASF AG

Inventor： KLUGE MICHAEL ,  KESSEL KNUT ,  GREINDL THOMAS ,  BIEDERMANN NORBERT ,  SCHERR GUENTER ,  BOGENSTAETTER THOMAS

IPC: C07C273/18 ,  C07C273/00 ,  C07C275/70

公开(公告)号：AT242204T

公开(公告)日：2003-06-15

申请号：AT99123307

申请日：1999-11-22

Applicant: BASF AG

Inventor： KLUGE MICHAEL ,  KESSEL KNUT ,  GREINDL THOMAS ,  BIEDERMANN NORBERT ,  SCHERR GUENTER ,  BOGENSTAETTER THOMAS

IPC: C07C273/18 ,  C07C273/00 ,  C07C275/70

公开(公告)号：CA2343259A1

公开(公告)日：2001-10-06

申请号：CA2343259

申请日：2001-04-05

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JORG ,  KESSEL KNUT ,  SCHERR GUNTER ,  BOGENSTATTER THOMAS

IPC: A61K9/20 ,  A61K31/198 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02 ,  A61P21/00 ,  C08K5/29 ,  C08L101/00

Abstract: a) a mixture which comprises at least one thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder and creatine, and contains 1 to 20 mol of water per mol of creatine is prepared, b) the mixture is plasticated at or above the softening point of the polymeric binder, preferably with at least partial evaporation of the water, c) the plasticated mixture is shaped to dosage forms and cooled.