公开(公告)号：DE3209159A1

公开(公告)日：1983-09-15

申请号：DE3209159

申请日：1982-03-13

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DIPL CHEM DR ,  THYES MARCO DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  KOENIG HORST PROF DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26 ,  C07D237/14

Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula (I) where R is hydrogen, R1 is hydrogen or C1-C3-alkyl, or R and R1 together are methylene, R2 and R3 are identical or different and are each hydrogen or C1-C6-alkyl, and A is hydroxyl, C1-C6-alkoxy, C2-C7-acyloxy, a C2-C7-carbamic acid ester group, C1-C6-alkylsulfonyloxy, C1-C6-alkylmercapto, carboxyl, C2-C7-alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

公开(公告)号：DE3113094A1

公开(公告)日：1982-10-21

申请号：DE3113094

申请日：1981-04-01

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59 ,  C07D413/06

公开(公告)号：DE3027527A1

公开(公告)日：1982-02-18

申请号：DE3027527

申请日：1980-07-19

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ DIPL CHEM DR ,  NEUMANN PETER DIPL CHEM DR ,  SEYBOLD GUENTHER DIPL CHEM DR ,  LENKE DIETER PROF DR ,  FRIEDRICH LUDWIG DR

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P37/08 ,  C07D213/38 ,  C07D277/44 ,  C07D277/46 ,  C07D417/02 ,  C07D417/04 ,  C07D417/10

Abstract: Novel 2-substituted thiazol-2-yl-oxamic acid esters, processes for their preparation, and therapeutic agents which contain these compounds and are useful in the treatment of allergic disorders.

公开(公告)号：DE2935359A1

公开(公告)日：1981-03-26

申请号：DE2935359

申请日：1979-09-01

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR

IPC: C07D403/04 ,  A61K31/50 ,  A61P9/12 ,  C07D521/00 ,  A61K31/415

公开(公告)号：DE2854475A1

公开(公告)日：1980-07-03

申请号：DE2854475

申请日：1978-12-16

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  A61K31/52

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：DE2854191A1

公开(公告)日：1980-07-03

申请号：DE2854191

申请日：1978-12-15

Applicant: BASF AG

Inventor： THYES MARCO DIPL CHEM DR ,  GRIES JOSEF DR MED ,  LEHMANN HANS DIETER DR MED ,  LENKE DIETER PROF DR ,  KUNZE JOHANNES DR MED

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

公开(公告)号：DE2609353A1

公开(公告)日：1977-09-15

申请号：DE2609353

申请日：1976-03-06

Applicant: BASF AG

Inventor： BLIESENER JENS-UWE DIPL CHEM D ,  FRANKE ALBRECHT DIPL CHEM DR ,  HIMMELE WALTER DIPL CHEM DR ,  LENKE DIETER PROF DR ,  MUELLER CLAUS-DIETER DR MED

IPC: A61K31/135 ,  C07C87/34 ,  C07C85/12

Abstract: New diphenylcyclopropylmethylamine derivs. are cpds. of formula (I) including the optically active forms) and their physiologically tolerable acid addn. salts. In formula (I), R1 is lower alkyl; R2 is dialkylamino, or an opt. substd. mono- or poly-nuclear aromatic residue; and A is 1-6C alkylene; in addn., R1 can be H when A is a residue -(CH2)n-CHR3-(CH2)m- in which n is 1,2,3 or 4 and m is 0, 1, 2, 3 or 4, or m and n are both 0, and R3 is H or 1-3C alkyl. (I) are useful as spasmolytics. The spasmolytic activity of (I) was demonstrated on guinea pig ileum segments suspended in oxygenated tyrode and artificially stimulated with BaCl2 (100 mg./l) or acetylcholine (0.1 mg./l.). 1- (2-Phenylpropylamino)methyl -2,2-diphenylcyclopropane in a concn. of 0.820 mg./l. gave 75% control of acetylcholine spasm (9.65 x papaverine) and in a concn. of 1.78 mg./l. gave 75% control of BaCl2 spasms (3.57 x papaverine). Specific cpds. (I) include 1- (2-phenylpropylamino)-methyl -2,2-diphenylcycloproprane.

公开(公告)号：DE3531504A1

公开(公告)日：1987-03-12

申请号：DE3531504

申请日：1985-09-04

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  HIMMELE WALTER DR ,  DEGNER DIETER DR ,  SIEGEL HARDO DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/47 ,  A61P1/04 ,  A61P43/00 ,  C07D207/32 ,  C07D207/335 ,  C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D409/06 ,  C07D417/12 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04

公开(公告)号：AT25083T

公开(公告)日：1987-02-15

申请号：AT84114255

申请日：1984-11-26

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  SPIEGLER WOLFGANG DR ,  SIEGEL HARDO DR ,  MUELLER CLAUS D DR ,  VON PHILIPSBORN GERDA DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：DE3444837A1

公开(公告)日：1986-06-12

申请号：DE3444837

申请日：1984-12-08

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C215/38 ,  C07C217/08 ,  C07D295/08 ,  C07D295/084 ,  C07C91/23 ,  C07C93/04 ,  C07D211/08