公开(公告)号：DE3242477A1

公开(公告)日：1984-05-24

申请号：DE3242477

申请日：1982-11-18

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  STEINER GERD DR ,  HOFMANN HANS PETER DR ,  MUELLER CLAUS D DR MED ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/428 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/46 ,  C07D209/48 ,  C07D275/04 ,  C07D275/06 ,  C07D495/04 ,  C07D513/04

公开(公告)号：DE3144150A1

公开(公告)日：1982-12-09

申请号：DE3144150

申请日：1981-11-06

Applicant: BASF AG

Inventor： DENGEL FERDINAND DIPL CHEM DR ,  EHRMANN OSKAR DIPL CHEM DR ,  FRANK WOLFRAM DR ,  FRIEDRICH LUDWIG DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF PROF DR MED ,  KURBJUWEIT HANS-GEORG DR ,  MUELLER CLAUS D DR MED ,  RASCHACK MANFRED DR ,  SEITZ WERNER DIPL CHEM DR ,  TREIBER HANS JOERG DR ,  WUPPERMANN DIRK DR MED ,  ZIMMERMANN FRANK DR MED

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

公开(公告)号：DE3444837A1

公开(公告)日：1986-06-12

申请号：DE3444837

申请日：1984-12-08

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C215/38 ,  C07C217/08 ,  C07D295/08 ,  C07D295/084 ,  C07C91/23 ,  C07C93/04 ,  C07D211/08

公开(公告)号：DE2941597A1

公开(公告)日：1981-04-23

申请号：DE2941597

申请日：1979-10-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  FRANKE ALBRECHT DIPL CHEM DR ,  PHILIPSBORN GERDA VON DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DE3243158A1

公开(公告)日：1984-05-24

申请号：DE3243158

申请日：1982-11-23

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR MED ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：DE2914615A1

公开(公告)日：1980-10-30

申请号：DE2914615

申请日：1979-04-11

Applicant: BASF AG

Inventor： LENKE DIETER PROF DR ,  MUELLER CLAUS D DR MED ,  GEISS KARL-HEINZ DIPL CHEM DR ,  BLIESENER JENS-UWE DIPL CHEM D

IPC: C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  C07D409/12 ,  A61K31/40 ,  C07D207/32

Abstract: Pyrrole derivs. of formula (I) and their therapeutically useful ammonium, alkali metal and acid addition salts are new: (R1 = satd., opt. substd. 1-8C aliphatic gp.; 2-8C unsatd. alkyl, 3-7C cycloalkyl, or 1-4C alkyl substd. by phenyl or 5-6 membered aromatic heterocycle with N, O or S atom (these rings are opt. substd. at least once); R2 = H; or R1 + R2 together complete a 4-6 membered satd. heterocycle; R3 = H or 1-5C alkyl; R4 and R5 = H or 1-5C alkyl; X is O, S, SO or NH; Ar = phenyl, opt. substd. 1-3 times). (I) are diuretics useful in treatment of oedema and hypertension. They are given orally at 0.1-100 mg/kg/day or intravenously at 0.05-10 mg/kg/day.

公开(公告)号：DE3309595A1

公开(公告)日：1984-09-20

申请号：DE3309595

申请日：1983-03-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  GRIES JOSEF DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: C07D211/52 ,  A61K31/13 ,  A61K31/445 ,  A61K31/451 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C313/00 ,  C07C323/25 ,  C07D211/44 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07C93/14 ,  A61K31/485

Abstract: Compounds of the general formula I where R1, R2, R3, R4 and n have the meanings given in the description, are useful for treating cardiac disorders.

公开(公告)号：DE2950064A1

公开(公告)日：1981-06-19

申请号：DE2950064

申请日：1979-12-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DIPL CHE ,  PHILIPSBORN GERDA VON DR MED ,  MUELLER CLAUS D DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/4433 ,  A61K31/445 ,  A61P9/06 ,  C07D333/38 ,  C07D409/12 ,  A61K31/38

Abstract: Substituted piperidino-alkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.

公开(公告)号：DE2831850A1

公开(公告)日：1980-02-07

申请号：DE2831850

申请日：1978-07-20

Applicant: BASF AG

Inventor： BLIESENER JENS-UWE DIPL CHEM D ,  GEISS KARL-HEINZ DIPL CHEM DR ,  LENKE DIETER PROF DR ,  MUELLER CLAUS D DR MED

IPC: A61K31/40 ,  A61K31/4025 ,  A61P7/10 ,  C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  C07D405/12 ,  C07D409/10 ,  C07D207/32 ,  A61K31/335 ,  A61K31/38 ,  A61K31/435 ,  C07D409/12

Abstract: Pyrrol derivs. of formula (I) and their therapeutically useful ammonium alkali metal and acid addn. salts are new. R1=satd, opt. substd. 1-8C aliphatic pg. 2-8C unsatd. alkyl, 3-7C cycloalkyl, or 1-4C alkyl substd. by phenyl or 5-or 6-membered aromatic heterocycle with N,O or S atoms (both opt. poly substd.). R2=H, or R1R2N is a 4-6 membered satd. heterocycle R3=H or 1-5C alkyl. X is O, S, SO or NH. They are made e.g. by reacting an appropriately substd. 3-sulphonamido benzoic acid with 2,5-dimethoxy-tetrahydrofuran.