公开(公告)号：JPH11189521A

公开(公告)日：1999-07-13

申请号：JP29670198

申请日：1998-10-19

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR

IPC: A61K8/00 ,  A61K8/40 ,  A61K31/00 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To obtain a light-fast UV filter having a high absorbance due to the absorption in a UV-A region, scarcely manifesting an intrinsic color, i.e., having a sharp band structure and soluble in an oil or water by including a specific substituted α-methylstyrene derivative therein. SOLUTION: This substituted α-methylstyrene derivative represented by formula I [R is a 1-10C alkoxy or the like; R is H, a 2-10C alkyl or the like; R and R are each COOR or the like; R and R are each H, a (substituted) 1-12C alkyl or the like] (e.g. a compound represented by formula II) is used alone as a light-fast UV filter in a preparation for cosmetics and a pharmaceutical preparation or together with a well-known UV absorbing compound for the preparation for the cosmetics and the pharmaceutical preparation in order to protect human skin or human hair from sunlight. The compound represented by formula I is obtained by carrying out the condensation reaction of a compound represented by formula III with a compound represented by formula IV.

公开(公告)号：JPH11124564A

公开(公告)日：1999-05-11

申请号：JP22461198

申请日：1998-08-07

Applicant: BASF AG

Inventor： KELLER HARALD DR ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  PREISS THOMAS DR

IPC: A61K8/00 ,  A61K8/90 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  C08F216/14 ,  C08F216/16 ,  C08F216/18 ,  C08F218/00 ,  C08F218/10 ,  C08F220/36 ,  C09K3/00 ,  G02B1/04 ,  A61K7/06 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To obtain a polymeric ultraviolet absorber which exhibits a high water resistance, a low permeation into human skin, and a low residual monomer content and can be stably mixed and processed with other ingredients of cosmetic preparations by specifying the structures and contents of monomer units of the absorber. SOLUTION: The structural formulas of monomer units, a to d, are represented by formula I [wherein R and R are each H or a 1-8C alkyl; R is, e.g. a group of formula II; R is -(CO)n -R ; R is a 1-28C alkyl; n is 0 or 1; R is a 1-22C alkyl; and R is H or methyl]. The arrangement of monomer units is not limited, and the sum of a to d is 100; a is 5-95; b is 0-70; c is 5-95; and d is 0-70. The polymer is obtd. by the free radical polymn. of monomers for forming units a to d under normal conditions. The monomers are emulsified in water and copolymerized at 30-160 deg.C in the presence of a water-soluble initiator (e.g. azobisisobutyronitrile). The resultant polymer has a mol.wt. of 2,000-50,000 g/mol.

公开(公告)号：JPH11116455A

公开(公告)日：1999-04-27

申请号：JP22888398

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST ,  WUENSCH THOMAS DR ,  DROEGEMUELLER MICHAEL DR ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To prepare a cosmetic or the like, having a high absorbance in the UV-A area, showing a high photoresistibility and high stability, capable of manifesting pleasant touch feeling by using a specific 4,4-diarylbutadiene with a well-known compound. SOLUTION: This compound is 4,4-diarylbutadiene of formula I [R and R are each H, a 1-20C alkyl, a 2-10C alkenyl, an aryl or the like; R is H, COOR (R is H, a 1-20C alkyl or the like), a 1-20C alkyl, CN or the like; R is COOR (R is same as R ), CN, a 1-20C alkyl or the like; (n) is 1-3], e.g. the compound of formula II. The compound of formula I is obtained by condensing a compound of formula III with a compound of formula IV. The compound of formula I itself is well-known, and is used together with a compound used as a sun-screening agent for preparations for cosmetics and pharmaceutical preparations. The compound of formula I is preferably used in the proportion of 0.1-10 wt.% based on the whole quantity of the preparation.

公开(公告)号：JPH10120543A

公开(公告)日：1998-05-12

申请号：JP28836997

申请日：1997-10-21

Applicant: BASF AG

Inventor： SPERLING KARIN DR ,  WUENSCH THOMAS DR ,  WESTENFELDER HORST ,  TRENTMANN BEATE DR

IPC: C07D251/34 ,  A61K8/00 ,  A61K8/33 ,  A61K8/37 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  A61K7/44 ,  A61K7/06

Abstract: PROBLEM TO BE SOLVED: To obtain a cosmetic capable of protecting the skin and/or hair from UV radiation by containing a combination of a UV filter having light protectiveness with the other ingredient. SOLUTION: This cosmetic contains both (a) and (b) ingredients. The ingredient (a) is a UV filter A, B or C of the formula (as for A, R is 2-ethylhexyl; R is t-butyl; X is NH; as for B, R and R are each 2-isopropyl-5-methyl- cyclohexyl; X is O; as for C, R is methylcyclohexyl; X is O). The ingredient (b) is (25mol)-ethoxylated p-aminobenzoic ethyl ester, p-methoxycinnamic 2- ethylhexyl ester, 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate, 2- phenylbenzimidazolesulfonic acid or its salt, etc. This cosmetic, with the (a) and (b) ingredient contents at 0.1-15wt.%, respectively, can be prepared into such formulations as solution, oil, cream, ointment, lotion, gel and powder.

公开(公告)号：JP2001019627A

公开(公告)日：2001-01-23

申请号：JP2000180447

申请日：2000-06-15

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  PRECHTL FRANK ,  WUENSCH THOMAS DR ,  WESTENFELDER HORST

IPC: C07D233/64 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/49 ,  A61K47/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D239/70 ,  C07D263/56 ,  C07D277/64 ,  A61K7/42 ,  A61K7/00 ,  A61K7/025

Abstract: PROBLEM TO BE SOLVED: To obtain a photoprotective agent for cosmetics and medicines, absorbing in a high absorbance in the UV-A-region, having a pointed band structure and soluble in an oil or water depending on substituents. SOLUTION: A compound expressed by formula I [R1 and R2 are each an electrophilic group such as cyano, an alkyl or the like; R3 is H, a 1-20C alkyl or the like; X is a divalent group or the like such as O or S; Z is a group or the like expressed by formula II (R4 is H, an alkyl or the like which may bonds to a benzylidene ring I or the like)], (e.g. a compound expressed by formula III) is used singly or together with a UV-absorbing compound for other known preparations for cosmetics and medicines as a photo-stable UV-filter in preparations for cosmetics and medicines for protecting the human skin and hair from the sun light. The compound expressed by formula I is included preferably in 0.1-10 wt.% based on the whole amount of the preparations for cosmetics and medicines. The compound expressed by formula I is obtained by reacting, e.g. a compound expressed by formula IV with a compound expressed by formula V.

公开(公告)号：JP2000198762A

公开(公告)日：2000-07-18

申请号：JP35042399

申请日：1999-12-09

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  WUENSCH THOMAS DR ,  WESTENFELDER HORST

IPC: A61K8/00 ,  A61K8/40 ,  A61Q17/00 ,  A61Q17/04 ,  C07C67/343 ,  C07C69/618 ,  C07C253/30 ,  C07C255/41 ,  C09K3/00 ,  A61K7/44

Abstract: PROBLEM TO BE SOLVED: To obtain an oligomeric diarylbutadiene carboxylic ester having a specified oligomeric structure and high absorption in UV-A range, optically stable, soluble in oil or water according to its substrate group and applicable to preparing a light-shielding agent useful for cosmetics and pharmaceuticals. SOLUTION: The oligomeric 4,4-diarylbutadiene carboxylic ester of formula I [R1 and R2 are each H, an aliphatic group or the like; R3 is an aliphatic group, a cycloaliphatic group or the like; Y is O or a group of formula II (R4 is H, an aliphatic group or the like); (m) is 2-10; (n) is 1-3; X is a (m)-valent polyol group having 2-10 hydroxyl group] is obtained by Knoevenagel condensation of (m) mol aldehyde of formula III with an oligomeric (substituted) acetate of formula IV in an organic polar solvent (e.g. dimethylformamide) preferably at 40-150 deg.C using a catalyst (e.g. ammonium acetate).

公开(公告)号：JP2000143473A

公开(公告)日：2000-05-23

申请号：JP31255199

申请日：1999-11-02

Applicant: BASF AG

Inventor： WUENSCH THOMAS DR ,  WESTENFELDER HORST

IPC: A61K8/00 ,  A61K8/19 ,  A61K8/27 ,  A61K8/49 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/42 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a cosmetic or a medicinal preparation exhibiting a high light-protecting factor as much as possible with a very low concentration of a UV-absorbing agent by containing a specific triazine derivative and zinc oxide in a specific ratio. SOLUTION: This cosmetic or medicinal preparation contains (A) 0.1-10 wt.% one or more kinds of 1,3,5-triazine derivatives of formula I R1 to R3 are each a (substituted) 1-20C alkyl or a (hetero)aryl; X is O or NR4 [R4 is H, a (substituted) 1-20C alkyl or a (hetero)aryl]} and (B) 0.1-15 wt.% zinc oxide. Preferably, it contains 1-8 wt.% compound of the formula I in which R1 to R3 are each a 4-8C alkyl, X is O or NR4 (R4 is H or a 4-8C alkyl) and 0.1-10 wt.% component B, and more preferably contains 2-6 wt.% compound of the formula II of 2,4,6-trianilino-p-(carbo-2'-ethyl-hexyl-1'-oxy)-1,3,5-triazine and 2-8 wt.% component B. Preferably it has a light protecting factor of >14.

公开(公告)号：JP2000044451A

公开(公告)日：2000-02-15

申请号：JP15677699

申请日：1999-06-03

Applicant: BASF AG

Inventor： SCHUMACHER PETER ,  SCHNEIDER NORBERT ,  WESTENFELDER HORST ,  HAREMZA SYLKE DR ,  HABECK THORSTEN ,  MEYER FRANK

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/23 ,  A61K8/25 ,  A61K8/29 ,  A61K8/31 ,  A61K8/33 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K8/73 ,  A61K8/86 ,  A61K8/89 ,  A61K8/97 ,  A61K8/98 ,  A61K31/255 ,  A61K31/34 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C09B67/20 ,  C09C3/08 ,  C09K3/00 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To protect human epidermis or human hair against sunrays by using a specific cholesteric liquid crystal composition as a filter in a UV-A and a UV-B regions of a cosmetic and a medicine. SOLUTION: A cholesteric liquid crystal composition is obtained by including (A) a polymerizable chiral liquid crystal monomer capable of providing a cholesteric liquid crystal phase having

公开(公告)号：JPH11255613A

公开(公告)日：1999-09-21

申请号：JP35792198

申请日：1998-12-16

Applicant: BASF AG

Inventor： HABECK THORSTEN DR ,  HAREMZA SYLKE DR ,  TRAUTH HUBERT ,  SCHEHLMANN VOLKER DR ,  WESTENFELDER HORST

IPC: A61K8/49 ,  A61K8/00 ,  A61K31/4035 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07D209/46 ,  C08K5/3417 ,  C08L101/00 ,  C09D7/12 ,  C09K3/00 ,  C09K15/30 ,  A61K7/00 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To sufficiently effectively protect an organic material such as a plastic, a coating material, a cosmetic, a medicine, etc., by using a specific isoindolinone derivative as an stabilizer for an organic material. SOLUTION: An isoindolinone derivative of the formula [R is H, a COOR , a COR , CONR R (R and R are each H, a 1-20C alkyl, a 2-10C alkenyl or the like and these groups may be substituted), CN or the like and these groups may be substituted; R is COOR , COR , CONR R or CN; R and R are bonded to form a 7-10C bicycloalkyl or a 7-10C bicycloalkenyl; R is H, a 1-20C alkyl, a 2-10C alkenyl or the like and these groups may be substituted] is used for stabilizing an organic material to the action of light, oxygen, heat, etc. Preferably 0.01-10 wt.% based on the organic material of the derivative is used.

公开(公告)号：JPH11236332A

公开(公告)日：1999-08-31

申请号：JP32070498

申请日：1998-11-11

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  OSTERSEHLT BERND DR ,  WESTENFELDER HORST

IPC: C07D307/62 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/375 ,  A61K47/22 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To use a specific stabilized ascorbic acid derivative useful as an antioxidant for makeup and medicine preparations. SOLUTION: This derivative is shown by formula I (R is H, a 1-20C acyl, a 1-12C alkoxycarbonyl or an alkyl; R is H, a 1-20C acyl, a 1-12C alkoxycarbonyl, an alkyl or the like; R is H, NH4 , an alkali metal action or the like; R is a 1-12C alkoxycarbonyl) such as 2,5,6-tri- O-(isopropyloxycarbonyl)-L-ascoribic acid or the like. The derivative is obtained by reacting an ascorbic acid derivative of formula II with a 1-6C chain length alkyl halocarbonate (e.g. isopropyl chloroformate or the like).