中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

23 records (took 0.043 seconds)

    CYTOMETRY SYSTEM WITH SOLID NUMERICAL-APERTURE-INCREASING LENS
    11.
    发明专利
    CYTOMETRY SYSTEM WITH SOLID NUMERICAL-APERTURE-INCREASING LENS 未知

    公开(公告)号：CA2808499A1

    公开(公告)日：2012-02-23

    申请号：CA2808499

    申请日：2011-08-19

    Applicant: BIO RAD LABORATORIES

    Inventor： HENG XIN ,  PATT PAUL

    IPC: G01N21/00

    Abstract: Flow cytometry system includes a flow element through which a cell is transported in a flowing fluid. Flow element includes a bore bounded by a wall. Light source is configured to illuminate the cell. Optical system receives light emanating from the cell and directs at least some of received light to a light sensor. The optical system includes a numerical-aperture-increasing lens at a wall of the flow element. At least some of the received light passes through the numerical-aperture-increasing lens. The flow cytometry system may also include a beam splitter that directs two wavelength bands of emanating light such that light in two wavelength band preferentially reach different sensing locations via different paths. The system may also include an optical element placed in one of the paths, shifting a focal location of the affected path to compensate for chromatic aberration of the numerical-aperture-increasing lens.

    MICROASSEMBLED IMAGING FLOW CYTOMETER
    12.
    发明专利
    MICROASSEMBLED IMAGING FLOW CYTOMETER 未知

    公开(公告)号：CA2792628A1

    公开(公告)日：2011-09-22

    申请号：CA2792628

    申请日：2011-03-15

    Applicant: BIO RAD LABORATORIES

    Inventor： HENG XIN

    IPC: G01N15/14 ,  G06K9/00 ,  G06T5/30

    Abstract: A microassembled imaging cytometer includes a sensing location that undergoes relative motion with a cell. Light from a light source is focused by a focusing element to a plurality of focused illumination spots or lines at the sensing location, illuminating the cell as the cell traverses the sensing location. A collection lens collects light emanating from the cell and refocuses the collected light onto an array light sensor. The focusing element may include an array of microlenses having spherical or aspheric surfaces. The system may include a processing unit that constructs a digital image of the cell based at least in part on signals produced by the array light sensor indicating the intensity and distribution of light falling on the array light sensor. The system may characterize cells using light emanating from the cells by fluorescence.

    LINE SCAN CYTOMETRY SYSTEMS AND METHODS
    13.
    发明专利
    LINE SCAN CYTOMETRY SYSTEMS AND METHODS 未知

    公开(公告)号：CA2827726C

    公开(公告)日：2017-06-13

    申请号：CA2827726

    申请日：2012-02-21

    Applicant: BIO-RAD LABORATORIES INC

    Inventor： HENG XIN ,  PATT PAUL

    IPC: G01N15/10

    Abstract: Systems and methods for performing cytometry using a linear light sensor. An illumination field, a line scanned by the linear light sensor, or both are swept across a cell to be imaged. Relative motion between the cell and the swept illumination may be created using a movable optical component or components, by adhering cells to a plate and transporting the plate or by other techniques.

    Compact automated cell counter
    15.
    发明专利
    Compact automated cell counter 未知

    公开(公告)号：AU2010286499A1

    公开(公告)日：2012-03-15

    申请号：AU2010286499

    申请日：2010-08-30

    Applicant: BIO RAD LABORATORIES

    Inventor： MCCOLLUM TOM ,  PATT PAUL ,  SHEN FRANK ,  CHU DANIEL Y ,  FLORY DON ,  GRIFFIN MIKE ,  HENG XIN ,  HEFNER ELI

    IPC: G06K9/00 ,  C12M1/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

    NEAR REAL TIME OPTICAL PHASE CONJUGATION
    16.
    发明专利
    NEAR REAL TIME OPTICAL PHASE CONJUGATION 未知

    公开(公告)号：CA2774237C

    公开(公告)日：2015-10-27

    申请号：CA2774237

    申请日：2010-09-14

    Applicant: BIO RAD LABORATORIES

    Inventor： HENG XIN

    IPC: G02B27/00 ,  A61B6/00 ,  G02B26/08 ,  G02B27/10

    Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

    CYTOMETRY SYSTEM WITH SOLID NUMERICAL-APERTURE-INCREASING LENS
    18.
    发明公开
    CYTOMETRY SYSTEM WITH SOLID NUMERICAL-APERTURE-INCREASING LENS 审中-公开
    具有固定数值孔径增加镜头的细胞系统

    公开(公告)号：EP2606333A4

    公开(公告)日：2015-03-25

    申请号：EP11818860

    申请日：2011-08-19

    Applicant: BIO RAD LABORATORIES

    Inventor： HENG XIN ,  PATT PAUL

    IPC: G01N15/14 ,  G01N21/64

    CPC classification number: G01N15/1434 ,  G01N15/1436 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/645 ,  G01N2021/6421

    Abstract: A flow cytometry system includes a flow element through which a cell is transported in a flowing fluid. The flow element includes a bore bounded by a wall. A light source is configured to illuminate the cell. An optical system receives light emanating from the cell and directs at least some of the received light to a light sensor. The optical system includes a numerical-aperture-increasing lens at a wall of the flow element. At least some of the received light passes through the numerical-aperture-increasing lens. The flow cytometry system may also include a beam splitter that directs two wavelength bands of the emanating light such that light in two wavelength band preferentially reach different sensing locations via different paths. The system may also include an optical element placed in one of the paths, shifting a focal location of the affected path to compensate for chromatic aberration of the numerical-aperture-increasing lens.

Patent Agency Ranking