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公开(公告)号：BR0309947A
公开(公告)日：2005-03-01
申请号：BR0309947
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： HORN CARINA , HOENES JOACHIM , KNAPPE WOLFGANG-REINHOLD
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.
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公开(公告)号：CA2486950A1
公开(公告)日：2003-11-27
申请号：CA2486950
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HORN CARINA , HOENES JOACHIM
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: The invention relates to a method for producing polymer layers on a support by the photopolymerisation of a polymerisable liquid composition. The invention also relates to a device that is suitable for producing polymer layers on a support and to a method for producing a sensor, which contains a polymer lay er with an integrated indicator.
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公开(公告)号：NO340499B1
公开(公告)日：2017-05-02
申请号：NO20070946
申请日：2007-02-19
Applicant: HOFFMANN LA ROCHE
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公开(公告)号：HK1162672A1
公开(公告)日：2012-08-31
申请号：HK12103090
申请日：2012-03-28
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HILLER BERND , LEHR URSULA , ZIMMER VOLKER , PETRICH WOLFGANG , BEDON-GOMEZ LUIS DAVID
IPC: G01N20060101 , B01L20060101
Abstract: The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap.
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公开(公告)号：ES2370812T3
公开(公告)日：2011-12-23
申请号：ES01988775
申请日：2001-10-20
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE
Inventor： KRATZSCH PETER , SCHMUCK RAINER , BUNK DANIELA , SHAO ZHIXIN , THYM DETLEF , KNAPPE WOLFGANG-REINHOLD
Abstract: Mutante de forma soluble de EC 1,199,17, también conocida como dehidrogenasa de glucosa soluble dependiente de PQQ (s-GDH) estando caracterizado dicho mutante porque, con respecto a la enzima de tipo natural correspondiente y con respecto, como mínimo, a otro sustrato de azúcar seleccionado, tiene, como mínimo dos veces, una mayor especificidad de sustrato incrementada, para la glucosa, de manera que dicha mejora de la especificidad se calcula de acuerdo con la fórmula: actividad mutante glucosa actividad azúcar seleccionado tipo natural especificidad (mejora) = -------------------------------------------X----------------------------------------------------actividad glucosa tipo natural actividad mutante azúcar seleccionado, en la que dicho mutante comprende una sustitución de residuo de aminoácido en la posición de aminoácido correspondiente a la posición 348 de la secuencia de tipo natural de s-GDH conocida desde A. Calcoaceticus (SEQ ID NO: 24).
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Patent Agency Ranking
公开(公告)号：AT520777T
公开(公告)日：2011-09-15
申请号：AT01988775
申请日：2001-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： KRATZSCH PETER , SCHMUCK RAINER , BUNK DANIELA , SHAO ZHIXIN , THYM DETLEF , KNAPPE WOLFGANG-REINHOLD
IPC: C12N15/53 , G01N33/66 , C12M1/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12N11/02 , C12N15/09 , C12P21/02 , C12Q1/32 , C12Q1/54
Abstract: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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公开(公告)号：PL205561B1
公开(公告)日：2010-05-31
申请号：PL36254801
申请日：2001-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： KRATZSCH PETER , SCHMUCK RAINER , BUNK DANIELA , SHAO ZHIXIN , THYM DETLEF , KNAPPE WOLFGANG-REINHOLD
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公开(公告)号：AU2005263591B2
公开(公告)日：2008-08-14
申请号：AU2005263591
申请日：2005-07-19
Applicant: HOFFMANN LA ROCHE
Inventor： LAGGERBAUER JESSICA , KNAPPE WOLFGANG-REINHOLD , BOENITZ-DULAT MARA , SCHMUCK RAINER , KRATZSCH PETER
Abstract: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known fromto genes encoding such variant s-GDH, to proteins of such s-GDH variants with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugars, especially of glucose in a sample.
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公开(公告)号：AU2003240260B2
公开(公告)日：2008-05-22
申请号：AU2003240260
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： HOENES JOACHIM , KNAPPE WOLFGANG-REINHOLD , HORN CARINA
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.
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公开(公告)号：DK1504113T3
公开(公告)日：2007-03-05
申请号：DK03730061
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HORN CARINA , HOENES JOACHIM
IPC: C12M1/34 , C12Q1/00 , C08F2/00 , C12M1/40 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.
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