公开(公告)号：JPH06271446A

公开(公告)日：1994-09-27

申请号：JP6059993

申请日：1993-03-19

Applicant: KAO CORP

Inventor： TAKEMA YOSHINORI ,  OGAWA AYUMI ,  FUJIMURA TSUTOMU ,  KUSUOKU HIROSHI ,  OHASHI YUKIHIRO ,  KAWAMATA AKIRA ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/55 ,  A61K8/58 ,  A61K8/68 ,  A61P17/16 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain a wrinkle improver having excellent action capable of suppressing occurrence of wrinkle and removing wrinkle. CONSTITUTION:The wrinkle improver contains a sphingosine analogue of the formula [R is 1-40C straight-chain, branched chain or cyclic hydrocarbon group which may have OH; X is CH2OH, CO2H, CH2OP(=0) (OH)2; Y is NH2, NHCH3, N(CH3)2 or N (CH3)3, e.g. D-erythrosphingosine as an active ingredient. Although the wrinkle improver can be administered by oral, external or other any method, the improver is preferably applied as a skin external preparation, e.g. ointment and the blend amount of the compound of the formula is preferably 0.0001-5wt.%, especially preferably 0.0001-1wt.% in an emulsion type skin external preparation and preferably 0.001-10wt.%, especially preferably 0.005-2wt.% in an oily skin external preparation.

公开(公告)号：JPH09202709A

公开(公告)日：1997-08-05

申请号：JP27462796

申请日：1996-10-17

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  OGAWA AYUMI ,  TSUKAHARA KAZUE ,  TAKEMA YOSHINORI ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: C07H15/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/37 ,  A61K8/41 ,  A61K8/43 ,  A61K8/46 ,  A61K8/60 ,  A61K8/68 ,  A61Q19/00 ,  C07C279/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a skin cosmetic capable of exhibiting excellent crease improving effect and good feeling to users by combining a guanidine derivative having a specific structure or its acid addition salt with a synthetic sphingosine. SOLUTION: This skin cosmetic is obtained by combinedly using (A) a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond, CO or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, an alkyl, (AO)m -(BO)n -D-E] of formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phoshoric acid] or its acid addition salt and (B) a synthetic sphingosine derivative of formula III (R is a 4-40C hydrocarbon; R to R are each H or a 1-10C hydrocarbon; X and Y are each H or an alkyl). The skin cosmetic is preferably obtained by blending 0.001-50wt.% component A with 0.0001-10wt.% component B. An organic acid or its ester in an amount of 0.001-30wt.% may further be added to the system. The component of formula I is e.g. obtained from a compound of formula IV.

公开(公告)号：JPH08208463A

公开(公告)日：1996-08-13

申请号：JP28846895

申请日：1995-11-07

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  OGAWA AYUMI ,  OSU HIROYUKI ,  TAKEMA YOSHINORI ,  HORI KIMIHIKO ,  AMANO SHINYA ,  FUJIMORI TAKETOSHI ,  OHASHI YUKIHIRO ,  SUZUKI YASUTO

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K8/368 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/22 ,  A61K31/235 ,  A61K31/245 ,  A61K31/60 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/48

Abstract: PURPOSE: To obtain the subject agent effective for promoting the collagen synthesis in the skin and having excellent wrinkle smoothing action. CONSTITUTION: This collagen synthesis promoter contains a benzoic acid derivative of formula I [X is O or N(R ) (R is H, a 1-11C alkyl, an alkenyl, etc.); R is a 4-25C alkyl or an alkenyl; R is H, OH, a 1-6C alkoxy, etc.; R is OR (R is H, a 1-25C alkyl, etc.) or N(R )R (R and R are each H, a 1-3C alkyl or an alkenyl)] or its salt [e.g. 4-(3,7-dimethyl-6-octenyloxy)-2-hydroxybenzoic acid] as an active component. The compound of formula I can be produced e.g. by reacting a compound of formula II (R is R except for OH) with a compound of formula R -Y (Y is a halogen, p-toluenesulfonyloxy, etc.). The promoting agent is preferably used by external application and the compounding amount of the compound of formula I is preferably 0.001-10wt.%, especially 0.001-5wt.% based on the total composition in the case of an emulsion.