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公开(公告)号：CA3107758A1
公开(公告)日：2020-02-13
申请号：CA3107758
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：BR112021012154A2
公开(公告)日：2021-09-08
申请号：BR112021012154
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , BENSON SCOTT
Abstract: corante de rodamina assimétrica e uso da mesma em ensaios biológicos. a presente divulgação se refere a corantes nh-rodamina n-protegida e seu uso na detecção de ácido nucleico. em particular, a divulgação se refere a métodos de produção de corantes nh-rodamina n protegida e métodos de uso de corantes nh-rodamina n-protegida (por exemplo, identificação humana). certos corantes fornecidos neste documento têm propriedades espectrais únicas que complementam aquelas em conjuntos de corantes existentes e podem ser usados para expandir o número de corantes repórter que podem ser incluídos para aplicações hid e outros ensaios biológicos. esses compostos fluorescentes são úteis para marcar oligonucleotídeos sintéticos. fórmula (i).
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公开(公告)号：AU2019404556A1
公开(公告)日：2021-06-24
申请号：AU2019404556
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , BENSON SCOTT
Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).
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公开(公告)号：AU2019226572A1
公开(公告)日：2020-09-03
申请号：AU2019226572
申请日：2019-03-01
Applicant: LIFE TECHNOLOGIES CORP
Inventor： MULLAH KHAIRUZZAMAN BASHAR , EVANS BRIAN , BENSON SCOTT C , CHANG CHU-AN , YAN XIONGWEI
IPC: C07H21/00 , C12Q1/6818 , C12Q1/686
Abstract: Disclosed is a probe for use in biological assays. The probe includes a fluorescent dye bound to a quencher compound through an oligonucleotide linker. Also disclosed are methods of using the probe, such as for a polymerase chain reaction (PCR), such as in a quantitative PCR reaction (qPCR), as well as kits including the probe.
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公开(公告)号：AU2019319901B2
公开(公告)日：2022-07-07
申请号：AU2019319901
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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Patent Agency Ranking
公开(公告)号：AU2019319901A1
公开(公告)日：2021-02-18
申请号：AU2019319901
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：CA3124333A1
公开(公告)日：2020-06-25
申请号：CA3124333
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , BENSON SCOTT , MULLAH KHAIRUZZAMAN BASHAR , YAN XIONGWEI
Abstract: The present invention is directed to f luorescent rhodamine dyes having spectral properties suited to the creation of multiplex assay systems for use in molecular biology, cell biology and molecular genetics. The rhodamine dyes have the following structure:
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公开(公告)号：BR112021012146A2
公开(公告)日：2021-08-31
申请号：BR112021012146
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , KHAIRUZZAMAN BASHAR MULLAH , BENSON SCOTT , YAN XIONGWEI
Abstract: corante de rodamina modificado e uso do mesmo em ensaios biológicos. a presente divulgação se refere a corantes nh-rodamina n-protegida e seu uso na detecção de ácido nucleico. em particular, a divulgação se refere a métodos de produção de corantes nh-rodamina n-protegida e métodos de uso de corantes nh-rodamina n-protegida (por exemplo, identificação humana). certos corantes fornecidos neste documento têm propriedades espectrais únicas que complemen-tam aquelas em conjuntos de corantes existentes e podem ser usados para expan-dir o número de corantes repórter que podem ser incluídos para ensaios biológicos de multiplexação.
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公开(公告)号：SG11202106121SA
公开(公告)日：2021-07-29
申请号：SG11202106121S
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , BENSON SCOTT
Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).
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公开(公告)号：CL2021000340A1
公开(公告)日：2021-07-02
申请号：CL2021000340
申请日：2021-02-09
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , RUKAVISHNIKOV ALEKSEY
IPC: C09B11/14 , C09B69/00 , C12Q1/6869 , G01N33/58
Abstract: Los compuestos de rodamina sustituidos con silicio se describen en la presente. En la presente se describen también tintes de SiR que comprenden al menos un grupo vinilo unido al átomo de Si (posición 10) del tinte de SiR. También se proporcionan derivados, versiones funcionalizadas, conjugados, kits, métodos sintéticos relacionados y usos de compuestos de SiR. Los tintes de silicio-rodamina (SiR) pueden proporcionar una fluorescencia brillante en longitudes de onda de rojo lejano y mostrar buena fotoestabilidad. Los compuestos descritos en la presente pueden ser útiles para el marcado fluorescente y la detección de muestras biológicas.
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