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公开(公告)号：RU2744460C2
公开(公告)日：2021-03-09
申请号：RU2016144479
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/10 , A61K9/20 , A61K31/167 , A61K31/404 , A61K31/47 , A61K47/20 , A61K47/38 , A61P11/00
Abstract: Данноеизобретениехарактеризуетсякомпозициями, содержащимимножествотерапевтическихагентов, гдеприсутствиеодноготерапевтическогоагентаулучшаетсвойства, поменьшеймере, одногодругоготерапевтическогоагента. Водномвариантетерапевтическимиагентамиявляютсямуковисцидозныетрансмембранныерегуляторыпроводимости (CFTR), такиекаккорректор CFTR илиусилитель CFTR, длялеченияопосредованных CFTR заболеваний, такихкакмуковисцидоз. Такжеописаныспособыи наборы, содержащиеих. 7 н. и 40 з.п. ф-лы, 15 ил., 24 табл., 14 пр.
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公开(公告)号：SI3551622T1
公开(公告)日：2021-02-26
申请号：SI201730537
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D231/00
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公开(公告)号：RS61150B1
公开(公告)日：2020-12-31
申请号：RSP20201477
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：MA40004B1
公开(公告)日：2018-12-31
申请号：MA40004
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： CHANDRAN SACHIN , DOKOU ELENI , KNEZIC DRAGUTIN , MEDEK ALES , PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , FERRIS LORI ANN , MCCARTY KATIE LYNN , WAGGENER SARA A
IPC: A61K31/404 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06 , C07D209/04 , C07D215/00
Abstract: La présente invention concerne des compositions comprenant une pluralité d'agents thérapeutiques dans lesquelles la présence d'un agent thérapeutique améliore les propriétés d'au moins un autre agent thérapeutique. Dans un mode de réalisation, les agents thérapeutiques sont des régulateurs de la conductance transmembranaire de la mucoviscidose (cftr), tel qu'un correcteur du cftr ou un agent stimulant le cftr, destinés à traiter des maladies liées au cftr, telles que la mucoviscidose. L'invention concerne également des procédés et des kits.
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公开(公告)号：LT3131582T
公开(公告)日：2018-10-25
申请号：LT15721912
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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Patent Agency Ranking16.发明专利
公开(公告)号：SI3131582T1
公开(公告)日：2018-09-28
申请号：SI201530270
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/00 , A61K9/00 , A61K31/00 , C07D209/00 , C07D215/00
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公开(公告)号：DK3131582T3
公开(公告)日：2018-08-06
申请号：DK15721912
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A , BRODEUR GEOFFREY GLEN
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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公开(公告)号：CL2016002600A1
公开(公告)日：2017-08-18
申请号：CL2016002600
申请日：2016-10-13
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K31/404 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06 , C07D209/04 , C07D215/00
Abstract: ESTE INVENTO CARACTERIZA COMPOSICIONES QUE COMPRENDEN UNA PLURALIDAD DE AGENTES TERAPÉUTICOS EN DONDE LA PRESENCIA DE UN AGENTE TERAPÉUTICO INTENSIFICA LAS PROPIEDADES DE POR LO MENOS UN OTRO AGENTE TERAPÉUTICO. EN UNA REALIZACIÓN, LOS AGENTES TERAPÉUTICOS SON REGULADORES DE CONDUCTANCIA TRANSMEMBRANA DE LA FIBROSIS QUÍSTICA (CFTR) TALES COMA UN CORRECTOR DEL CFTR O UN POTENCIADOR DEL CFTR PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS PAR CFTR, TALES COMO FIBROSIS QUÍSTICA. SE DIVULGAN TAMBIÉN MÉTODOS Y JUEGOS DE IMPLEMENTOS.
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公开(公告)号：SG11201607670XA
公开(公告)日：2016-10-28
申请号：SG11201607670X
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.
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公开(公告)号：MA55774A
公开(公告)日：2022-03-30
申请号：MA55774
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , PHENIX BRIAN DEAN , WAGGENER SARA A
IPC: A61K31/404 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06 , C07D209/04 , C07D215/00
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