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公开(公告)号：CL2019001553A1
公开(公告)日：2020-04-03
申请号：CL2019001553
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： FERRIS LORI ANN , ANDERSON COREY , CLEVELAND THOMAS , KHATUYA HARIPADA , MCCARTNEY JASON , UY JOHNNY , ZHOU JINGLAN , ALCACIO TIMOTHY , BAEK MINSON , KESHAVARZ-SHOKRI ALI , PARASELLI PRASUNA , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KRENITSKY PAUL JOHN , MILLER MARK THOMAS , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ABELA ALEXANDER RUSSELL , ANGELL PAUL TIMOTHY , CLEMENS JEREMY J , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY
IPC: C07D231/20 , A61K31/455 , A61P11/00 , C07D401/04 , C07D401/14
Abstract: COMPUESTOS HETEROCÍCLICOS MODULADOR DEL REGULADOR DE CONDUCTANCIA TRANSMEMBRANA DE FIBROSIS QUÍSTICA; COMPOSICIONES FARMACÉUTICAS; PROCESO PARA PREPARAR EL MODULADOR; FORMAS CRISTALINAS Y USO EN EL TRATAMIENTO DE LA FIBROSIS QUÍSTICA.
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公开(公告)号：SI3551622T1
公开(公告)日：2021-02-26
申请号：SI201730537
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D231/00
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公开(公告)号：RS61150B1
公开(公告)日：2020-12-31
申请号：RSP20201477
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：MA49235A
公开(公告)日：2019-10-16
申请号：MA49235
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: A61P11/00 , A61K31/455 , C07D231/20 , C07D401/04 , C07D401/14
Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.
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公开(公告)号：PE20191304A1
公开(公告)日：2019-09-23
申请号：PE2019001200
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , VAN GOOR FREDRICK , YOUNG TOMOTHY JOHN , ZHOU JINGLAN , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , GROOS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Referido a un compuesto de formula I, su sal farmaceuticamente aceptable o un derivado deuterado del mismo, en donde: uno de Y1 e Y2 es N el otro es CH; X es N(alquilo C1-C4), O u NH; R1 es -(C(R2)2)k-O-(C(R2)2)mR7; cada R2 es H, halogeno, ente otros; cada R3 es alquilo C1-C4 sustituido opcionalmente, entre otros; K es 0 o 1; r es 0 o 1; m es 0, 1, 2 o 3; p es p, 1 o 2; y q es 0, 1, 2, 3, 4, 5, 6, 7 u 8. Estos compuestos modulan el regulador de conductancia transmembrana de fibrosis quistica (CFTR); tambien se refiere a metodos de preparacion de dichos compuestos, sus compuestos intermedios y una composicion farmaceutica que los contiene.
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Patent Agency Ranking
公开(公告)号：ECSP19048759A
公开(公告)日：2019-07-31
申请号：ECDI201948759
申请日：2019-07-09
Applicant: VERTEX PHARMA
Inventor： JASON MCCARTNEY , PAUL JOHN KRENITSKY , SHI YI , FABRICE JEAN DENIS PIERRE , HARIPADA KHATUYA , TIMOTHY ALCACIO , ANGELL PAUL TIMOTHY , ROBERT M HUGHES , THOMAS CLEVELAND , FERRIS LORI ANN , SARA SABINA HADIDA RUAH , JOHNNY UY , DAVID ANDREW SIESEL , GULEVICH ANTON , MINSON BAEK , GROSS RAYMOND STANLEY , PRAMOD VIRUPAX JOSHI , ALI KESHAVARZ-SHOKRI , STAVROPOULOS KATHY , PRASUNA PARASELLI , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , HSIA CLARA KUANG-JU , ANDREAS P TERMIN , YOUNG TOMOTHY JOHN , VAN GOOR FREDRICK F , SHRESTHA MUNA , KANG PING , CLEMENS JEREMY J , JINGLAN ZHOU , GROOTENHUIS PETER DIEDERIK JAN , COREY ANDERSON
IPC: A61K31/455 , C07D231/20
Abstract: Se describen compuestos de Fórmula (I): (VER FÓRMULA EN LA DESCRIPCION) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los que anteceden y metabolitos de cualquiera de los anteceden. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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公开(公告)号：MX388103B
公开(公告)日：2025-03-19
申请号：MX2019006637
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , KESHAVARZ-SHOKRI ALI , TERMIN ANDREAS P , GULEVICH ANTON , HSIA CLARA KUANG-JU , ANDERSON COREY , SIESEL DAVID ANDREW , PIERRE FABRICE JEAN DENIS , VAN GOOR FREDRICK F , KHATUYA HARIPADA , MCCARTNEY JASON , CLEMENS JEREMY J , ZHOU JINGLAN , UY JOHNNY , STAVROPOULOS KATHY , FERRIS LORI ANN , MILLER MARK THOMAS , BAEK MINSON , SHRESTHA MUNA , KRENITSKY PAUL JHON , ANGELL PAUL TIMOTHY , GROOTENHUIS PETER DIEDIERIK JAN , KANG PING , JOSHI PRAMOD VIRUPAX , PARASELLI PRASUNA , GROSS RAYMOND STANLEY , HUGHES ROBERT M , HADIDA RUAH SARA SABINA , CLEVELAND THOMAS , ALCACIO TIMOTHY , YOUNG TOMOTHY JOHN , SHI YI
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Se describen compuestos de Fórmula (I): (ver fórmulas) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los anteriores y metabolitos de cualquiera de los anteriores. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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公开(公告)号：AU2021211993A1
公开(公告)日：2021-08-26
申请号：AU2021211993
申请日：2021-08-03
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOND VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Abstract Compounds of Formula (I): )S 0 0 x y 1 N (R), R1 (R3 (R4)(, pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：DK3551622T3
公开(公告)日：2020-11-23
申请号：DK17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：CA3046086A1
公开(公告)日：2018-06-14
申请号：CA3046086
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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