公开(公告)号：CA2892608A1

公开(公告)日：2014-06-12

申请号：CA2892608

申请日：2013-12-06

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  DAVIS REBECCA ,  DURRANT STEVEN ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  JIMENEZ JUAN-MIGUEL ,  KAY DAVID ,  KNEGTEL RONALD ,  MIDDLETON DONALD ,  ODONNELL MICHAEL ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  SHAW DAVID ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN ,  TWIN HEATHER

IPC: C07D487/04 ,  A61K31/495 ,  A61P35/00

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula (I-A) or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

公开(公告)号：ZA201208373B

公开(公告)日：2014-01-29

申请号：ZA201208373

申请日：2012-11-07

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HAYLEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：AU2012240030A1

公开(公告)日：2013-10-24

申请号：AU2012240030

申请日：2012-04-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  MACCORMICK SOMHAIRLE ,  STORCK PIERRE-HENRI ,  PINDER JOANNE ,  O'DONNELL MICHAEL EDWARD ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  YOUNG STEPHEN CLINTON YOUNG ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  DURRANT STEVEN JOHN ,  TWIN HEATHER CLARE ,  DAVIS CHRISTOPHER JOHN

IPC: C07D413/14 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in

公开(公告)号：CA2798763A1

公开(公告)日：2011-11-17

申请号：CA2798763

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HAYLEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

公开(公告)号：HRP20202058T1

公开(公告)日：2021-02-19

申请号：HRP20202058

申请日：2020-12-23

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  DAVIS REBECCA ,  DURRANT STEVEN ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  JIMENEZ JUAN-MIGUEL ,  KAY DAVID ,  KNEGTEL RONALD ,  MIDDLETON DONALD ,  ODONNELL MICHAEL ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  SHAW DAVID ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN ,  TWIN HEATHER

IPC: C07D487/04 ,  A61K31/495 ,  A61P35/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

公开(公告)号：DK3418281T3

公开(公告)日：2020-12-07

申请号：DK18159811

申请日：2013-12-06

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  DAVIS REBECCA ,  DURRANT STEVEN ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMINE ,  JIMENEZ JUAN-MIGUEL ,  KAY DAVID ,  KNEGTEL RONALD ,  MIDDLETON DONALD ,  ODONNELL MICHAEL ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  SHAW DAVID ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN ,  TWIN HEATHER

IPC: C07D487/04 ,  A61K31/495 ,  A61P35/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

公开(公告)号：SG11202006832YA

公开(公告)日：2020-08-28

申请号：SG11202006832Y

申请日：2019-01-28

Applicant: MERCK PATENT GMBH ,  VERTEX PHARMA

Inventor： BLEICH MATTHEW ,  CHARRIER JEAN-DAMIEN ,  DONG HUIJUN ,  DURRANT STEVEN ,  ENO MEREDITH SUZANNE ,  ETXEBARRIA I JARDI GORKA ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  KNEGTEL RONALD ,  MOCHALKIN IGOR ,  NORTH KIRI ,  PORICHIS FILIPPOS ,  PULLIN ROBERT ,  QIU HUI ,  STORCK PIERRE-HENRI ,  TWIN HEATHER CLARE ,  XIAO YUFANG

IPC: A61K31/395 ,  A61K31/437 ,  A61K31/4375 ,  C07D231/02 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：SI3152212T1

公开(公告)日：2020-06-30

申请号：SI201531129

申请日：2015-05-28

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  KNEGTEL RONALD ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN

IPC: C07D487/00

公开(公告)号：DK3152212T3

公开(公告)日：2020-03-16

申请号：DK15745265

申请日：2015-05-28

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  KNEGTEL RONALD ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN

IPC: C07D487/04

公开(公告)号：AU2019206032A1

公开(公告)日：2019-08-01

申请号：AU2019206032

申请日：2019-07-17

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  KNEGTEL RONALD ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN

IPC: C07D487/04

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-1 or I-A: N F y N N- N F F y2 I-1 I-A wherein the variables are as defined herein.