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公开(公告)号：WO2022094016A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056956
申请日：2021-10-28
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： LEVEILLE, Wade P. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , FOGWILL, Michael O.
Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.
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公开(公告)号：WO2019229676A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/054455
申请日：2019-05-29
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , MICHIENZI, Joseph D.
Abstract: The present disclosure relates to methodologies, systems, apparatus, and kits for introducing a sample within a chromatography system. A makeup pump is configured to pump a makeup fluid through a first restrictor into the chromatography system upstream of the column and downstream of a mobile phase pump. The first restrictor is located upstream of a column and downstream of makeup pump and a sample fluid pump. Decreasing an output volume of the makeup pump can direct a sample fluid from the sample fluid pump through the first restrictor to the column. Increasing an output volume of the makeup pump can direct the sample fluid to a second restrictor located downstream of the makeup pump and in parallel with the column and the detector.
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公开(公告)号：WO2019224702A2
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge. The cartridge incudes a barrel with a first and second end, a column segment connected to the second end of the barrel, and a column containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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14.发明申请
公开(公告)号：WO2018158731A1
公开(公告)日：2018-09-07
申请号：PCT/IB2018/051325
申请日：2018-03-01
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , SHREVE, Joshua A. , EGGERTSON, Michael , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , TARAFDER, Abhijit
CPC classification number: G01N30/32 , B01D15/163 , B01D15/40 , G01N30/34 , G01N30/7233 , G01N2030/326
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO 2 -based chromatography system. A first pressure control element is located downstream of a CO 2 -based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.
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公开(公告)号：WO2018148353A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017329
申请日：2018-02-08
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , GILAR, Martin , GRITTI, Fabrice , MICHIENZI, Joseph D.
CPC classification number: G01N30/30 , G01N30/34 , G01N30/6095 , G01N2030/027 , G01N2030/3015 , G01N2030/3038 , G01N2030/3046 , G01N2030/3053
Abstract: A method of performing a chromatographic separation includes generating a spatial temperature gradient along a length of a chromatographic column in a liquid chromatography system. A sample is injected into a flow of a mobile phase to the column and a flow of a mobile phase having a composition gradient is provided to the column after the sample is received at the column. The spatial temperature gradient is moved along the length of the column from the column inlet to the column outlet during the time that the composition gradient traverses the column. This coordination of the composition gradient with the movement of the spatial thermal gradient yields a significant increase in peak capacity per unit time compared with conventional separation techniques performed in a conventional isothermal column environment.
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Patent Agency Ranking
公开(公告)号：WO2018134750A1
公开(公告)日：2018-07-26
申请号：PCT/IB2018/050293
申请日：2018-01-17
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： SONG, Xiangjin , MURPHY, James P. , FADGEN, Keith , LEVEILLE, Wade P., Sr. , MICHIENZI, Joseph D. , BELANGER, Jonathan L. , JUNG, Moon Chul , TARAFDER, Abhijit
Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
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17.发明申请MATCHING THERMALLY MODULATED VARIABLE RESTRICTORS TO CHROMATOGRAPHY SEPARATION COLUMNS 审中-公开将热调节变量限制器与色谱分离柱匹配
公开(公告)号：WO2014158340A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/013985
申请日：2014-01-31
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , MICHIENZI, Joseph D. , GERHARDT, Geoff
CPC classification number: G01N30/32 , B01D15/08 , B01D15/161 , B01D15/163 , B01D15/40 , G01N30/8658 , G01N2030/025 , G01N2030/324
Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
Abstract translation: 色谱系统中使用的热调节变量限制器可以独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 用于配置独立控制可压缩流动相的系统压力和质量流量的色谱系统的方法包括确定用于色谱系统的色谱分离柱的类型，将热调节的可变限制器与色谱分离的类型相匹配 色谱柱在色谱系统运行期间一起使用，并将色谱柱与其匹配的热调节变量限制器捆绑在一起，作为单个包装进行分配。
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公开(公告)号：WO2023091653A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050381
申请日：2022-11-18
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , MICHIENZI, Joseph D. , BESNER, Sebastien , COOK, Brett G. , O'BRIEN, Peter
Abstract: A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.
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公开(公告)号：WO2019224702A3
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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20.发明申请
公开(公告)号：WO2019224701A1
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054161
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
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