公开(公告)号：NO971675A

公开(公告)日：1997-06-10

申请号：NO971675

申请日：1997-04-11

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  KLINGE DAGMAR ,  AMBERG WILHELM ,  KLING ANDREAS ,  MUELLER STEFAN ,  BAUMANN ERNST ,  RHEINHEIMER JOACHIM ,  VOGELBACHER UWE JOSEF ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D291/04

CPC classification number: C07D495/04 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/20 ,  C07D251/26 ,  C07D251/52 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

公开(公告)号：CA2228002A1

公开(公告)日：1997-03-13

申请号：CA2228002

申请日：1996-08-29

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  RIECHERS HARTMUT ,  AMBERG WILHELM ,  KLINGE DAGMAR ,  HERGENR DER STEFAN ,  SCHULT SABINE ,  ELGER BERND ,  KLING ANDREAS ,  UNGER LILIANE

IPC: C07D317/02 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/36 ,  A61K31/435 ,  A61K31/44 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  C07C53/134 ,  C07C57/30 ,  C07C57/32 ,  C07C57/38 ,  C07C59/64 ,  C07C69/616 ,  C07C69/734 ,  C07C255/00 ,  C07D213/55 ,  C07D213/64 ,  C07D221/04 ,  C07D239/26 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D257/04 ,  C07D307/79 ,  C07D317/50 ,  C07D317/60 ,  C07D319/02 ,  C07D319/18 ,  C07D275/02 ,  C07D261/06 ,  C07D405/06 ,  C07D285/12 ,  C07D239/24 ,  A61K31/275 ,  A61K31/33 ,  C07C59/42 ,  C07C255/57 ,  C07C57/58 ,  C07C323/62 ,  C07D213/62 ,  C07D307/80

Abstract: Described are carboxylic acid derivatives of formula (I) in which R1 is a tetrazole or nitrile group, a COOH group or a group which can be hydrolysed to COOH, and the other substituents are as defined in the description.

公开(公告)号：ZA9502614B

公开(公告)日：1996-09-30

申请号：ZA9502614

申请日：1995-03-30

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROEGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：CA1337991C

公开(公告)日：1996-01-23

申请号：CA554039

申请日：1987-12-10

Applicant: BASF AG

Inventor： SEITZ WERNER ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  RUEBSAMEN KLAUS ,  GRIES JOSEF

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Disclosed are basically substituted phenylacetonitriles where R1, R2 and R3 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl, nitro or C1-C4-alkoxy, and two radicals in adjacent positions may furthermore together form a methylenedioxy, ethylenedioxy, 1,3-dioxatetramethylene, propylene or butylene group, R4 is a saturated or unsaturated alkyl or cycloalkyl group of not more than 8 carbon atoms or phenyl, R5 is hydrogen or C1-C4-alkyl, R6 is a saturated or unsaturated hydrocarbon radical of 6 to 15 carbon atoms which may contain a ring, and n is 2, 3 or 4. These compounds are useful for the treatment of disorders, such as cardiovascular disorders, in particular coronary heart disease, vasospasms, cerebral ischemia, hypertension and circulatory shock. They can also be used for the prophylaxis and therapy of gastric and duodenal ulcers and asthmatic disorders.

公开(公告)号：AT131819T

公开(公告)日：1996-01-15

申请号：AT89910438

申请日：1989-09-12

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  HOFMANN HANS PETER ,  SZABO LASZLO ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D243/08 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092

Abstract: PCT No. PCT/EP89/01058 Sec. 371 Date Mar. 18, 1991 Sec. 102(e) Date Mar. 18, 1991 PCT Filed Sep. 12, 1989 PCT Pub. No. WO90/03371 PCT Pub. Date Apr. 5, 1990.2-Hydroxy-3-phenoxy-propyl-substituted piperazines of the formula I I in which R1-R5, Y, m and n have the meaning indicated in the description, and the preparation thereof are described. The novel compounds are suitable for the therapy of oxygen deficiency diseases of the brain.

公开(公告)号：NO944476L

公开(公告)日：1994-12-09

申请号：NO944476

申请日：1994-11-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  SCHLECKER RAINER ,  ROEHL FRANZ ,  ZIPPLIES MATTHIAS ,  RASCHACK MANFRED ,  HAFNER MATTHIAS

IPC: A61K31/47 ,  C07D217/04 ,  C07D217/06

公开(公告)号：FI945488A0

公开(公告)日：1994-11-22

申请号：FI945488

申请日：1994-11-22

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  SCHLECKER RAINER ,  ROEHL FRANZ ,  ZIPPLIES MATTHIAS ,  RASCHACK MANFRED ,  HAFNER MATTHIAS

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P31/04 ,  C07D217/04 ,  C07D217/06 ,  C07D

公开(公告)号：MX9203497A

公开(公告)日：1992-08-01

申请号：MX9203497

申请日：1992-06-26

Applicant: BASF AG

Inventor： SEITZ WARNER ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  RUEBSMEN KLAUS ,  GRIES JOSEF

IPC: C07C255/25

公开(公告)号：CA1268471A

公开(公告)日：1990-05-01

申请号：CA524528

申请日：1986-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

Abstract: Phenylacetaldehydes which are substituted by basic groups, of the formula: where R1 to R8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the circulatory disorders, including cardiac diseases, high blood pressure, disturbances of blood flow and in the treatment of gastric and duodenal ulcers.

公开(公告)号：NO162557B

公开(公告)日：1989-10-09

申请号：NO852793

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.