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    SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM
    251.
    发明申请
    SILYL PHOSPHORYLATING REAGENTS AND METHODS OF USING THEM 审中-公开
    SILYL PHOSPHORYLATING试剂及其使用方法

    公开(公告)号：WO1992021689A1

    公开(公告)日：1992-12-10

    申请号：PCT/US1992004677

    申请日：1992-06-05

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CELEBUSKI, Joseph, E. ,  JONES, Roger, A.

    IPC: C07H19/10

    CPC classification number: C07H21/00 ,  C07F7/081 ,  C07F9/2408 ,  C07H19/10 ,  C07H19/20 ,  Y02P20/55

    Abstract: Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing silyl substituted alcohols include hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.

    Abstract translation: 具有与硅结合的体积大的取代基的新型甲硅烷醇和连接到碳上的甲硅烷基包括优选的2-甲硅烷基 - 乙-1-醇。 合成甲硅烷基取代的醇的方法包括乙烯基酯，特别是乙酸乙烯酯的硅氢化，然后在温和的碱中水解。 甲硅烷醇可用于制备磷酸化寡核苷酸的磷酸化试剂。 承载甲硅烷基的磷酸化中间体可以基于甲硅烷基保护基团上的庞大的取代基与后续的产物分离，其随后被除去。 由氟离子。

    HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR COTININE
    255.
    发明申请
    HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR COTININE 审中-公开
    生活习惯，追踪者，免疫球蛋白和抗体免疫免疫

    公开(公告)号：WO1992012975A1

    公开(公告)日：1992-08-06

    申请号：PCT/US1992000382

    申请日：1992-01-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  WALLING, John, A. ,  HU, Hsiang-Yun ,  HASZ, Barbara, E.

    IPC: C07D401/04

    CPC classification number: C07D401/04 ,  G01N33/5308

    Abstract: Disclosed is a substantially optically pure hapten, useful in an immunoassay for cotinine. The hapten corresponds to a specified structural formula (I). In formula (I) X is a straight or branched chain, saturated or unsaturated, divalent radical covalently bonded to a pyridyl ring at the number 2-, 4-, 5- or 6- position. The divalent radical, X, has from 1 to 10 carbon atoms wherein the chain of the divalent radical optionally may contain 1 or 2 hetero atoms selected from members of the group consisting of S, O and NZ in which Z represents a C1 to C3 alkyl group. In formula (I), n = 1 or 0, and Q is a functional group selected from -COOH, -NH2 (provided that n does not equal 0), -C(O)NHNH2, -O(CO)Cl, -CHO, -NCS or -NCO. Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten. Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for cotinine. Also disclosed is an improved immunoassay for determining cotinine in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining cotinine involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.

    PATENCY MAINTENANCE SYSTEM
    256.
    发明申请
    PATENCY MAINTENANCE SYSTEM 审中-公开
    专利维护制度

    公开(公告)号：WO1992011891A1

    公开(公告)日：1992-07-23

    申请号：PCT/US1991009822

    申请日：1991-12-27

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KOLBER, Chris, M.

    IPC: A61M25/00

    CPC classification number: A61M5/14 ,  A61M5/14248 ,  A61M25/0017 ,  A61M2005/1404

    Abstract: A method and apparatus for maintaining the patency of a vein access device (14) in which a dilute solution of an anticoagulant drug is slowly infused into the vein access device (14). The patency device includes a self-energized container (12) and means for adding a medicament without disconnecting the patency device from the vein access device (14). In accordance with a preferred embodiment, a self-energized container (12) delivers a heparin solution to the vein access device (14) at a concentration from about .01 to about 0.99 international heparin units per milliliter of diluen at a flow rate from about .01 to about 1.0 milliliters per hour.

    HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS
    257.
    发明申请
    HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS 审中-公开
    HEXA和HEPTAPEPAPDEANAPHYLATOXIN-RECEPTOR LIGANDS

    公开(公告)号：WO1992011858A1

    公开(公告)日：1992-07-23

    申请号：PCT/US1991009319

    申请日：1991-12-10

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  WIEDEMAN, Paul, E. ,  KAWAI, Megumi ,  LULY, Jay, R. ,  OR, Yat, Sun ,  WAGNER, Rolf

    IPC: A61K37/00

    CPC classification number: C07K14/472 ,  A61K38/00

    Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

    Abstract translation: 式A-B-D-E-G-J-L-M-Q的寡肽化合物或寡肽类似物化合物是过敏毒素受体的配体，可用于治疗炎性疾病状态。 还公开了过敏毒素受体配体组合物和调节过敏毒素活性的方法。

    QUINOLINE, NAPHTHYRIDINE AND PYRIDOBENZOXAZINE DERIVATIVES
    258.
    发明申请
    QUINOLINE, NAPHTHYRIDINE AND PYRIDOBENZOXAZINE DERIVATIVES 审中-公开
    喹啉，萘啶和吡唑并噻嗪衍生物

    公开(公告)号：WO1992010191A1

    公开(公告)日：1992-06-25

    申请号：PCT/US1991009419

    申请日：1991-12-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CHU, Daniel, T. ,  COOPER, Curt, S.

    IPC: A61K31/47

    CPC classification number: C07D401/04 ,  C07D471/04 ,  C07D491/10

    Abstract: Novel antibacterial compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters, amide and prodrugs thereof, wherein R1 is selected from the group consisting of (a) lower alkyl, (b) halo(lower alkyl), (c) lower alkyl(alkynyl), (d) lower cycloalkyl, (e) lower alkylamino, (f) nitrogen-containing aromatic heterocycle, (g) bicyclic alkyl and (h) phenyl; R2 is selected from the group consisting of hydrogen, lower alkyl, a pharmaceutically acceptable cation, and a prodrug ester group; R?3 and R4¿ are independently selected from the group consisting of hydrogen, halogen, amino, and lower alkyl; R5 is either a nitrogen-containing heterocycle or a nitrogen-containing spiro-bicyclic-heterocycle; and A is N or C-R6, wherein R6 is selected from the group consisting of hydrogen, halogen, lower alkyl, and lower alkoxy, or R?1 and R6¿ taken together with the atoms to which they are attached form a 6-membered ring which may contain an oxygen or sulfur atom and which may be substituted with lower alkyl; as well as pharmaceutical compositions comprising such novel compounds and the therapeutic use thereof.

    IMMUNOASSAY AND MONOCLONAL ANTIBODIES USEFUL FOR DETECTING TRUNCATED NERVE GROWTH FACTOR RECEPTOR
    259.
    发明申请
    IMMUNOASSAY AND MONOCLONAL ANTIBODIES USEFUL FOR DETECTING TRUNCATED NERVE GROWTH FACTOR RECEPTOR 审中-公开
    用于检测截肢神经生长因子受体的免疫和单克隆抗体

    公开(公告)号：WO1992009631A1

    公开(公告)日：1992-06-11

    申请号：PCT/US1991008968

    申请日：1991-12-02

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  DISTEFANO, Peter, S. ,  CLAGETT-DAME, Margaret

    IPC: C07K15/00

    CPC classification number: C07K16/2863 ,  C07K14/71 ,  G01N2333/71

    Abstract: Monoclonal antibodies which specifically bind to human nerve growth factor receptor, human truncated nerve growth factor receptor, monkey truncated nerve growth factor receptor, and which do not significantly bind to rat or chick nerve growth factor receptor, and hybridomas which produce these monoclonal antibodies. Also provided are assays which utilize these monoclonal antibodies to determine the presence of human nerve growth factor receptor or human truncated nerve growth factor receptor in a test sample, and asssay kits containing these monoclonal antibodies.

    Abstract translation: 特异性结合人神经生长因子受体，人截短的神经生长因子受体，猴截短的神经生长因子受体，并且不显着结合大鼠或鸡神经生长因子受体的单克隆抗体，以及产生这些单克隆抗体的杂交瘤。 还提供了利用这些单克隆抗体确定测试样品中人神经生长因子受体或人截短的神经生长因子受体的存在的测定法，以及含有这些单克隆抗体的唾液分析试剂盒。

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