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公开(公告)号：KR101747139B1
公开(公告)日：2017-06-14
申请号：KR1020140139734
申请日：2014-10-16
Applicant: 동화약품주식회사
CPC classification number: A61K36/19 , A23L33/105 , A23V2002/00 , A61K8/9789 , A61K2236/33 , A61K2236/331 , A61K2236/35 , A61P1/12 , A61P11/02 , A61P17/00 , A61P27/14 , A61P27/16 , A61P37/08
Abstract: 본발명은쥐꼬리망초(justicia) 속식물의추출물또는분획물을유효성분으로포함하는알레르기성질환의예방, 치료또는개선용약학적조성물, 식품조성물및 화장료조성물에관한것이다. 본발명의쥐꼬리망초속 식물의추출물또는분획물은 IgE 항체분비를억제하며, 비만세포및 호염기구의탈과립 (degranulation)을억제할수 있고, 우수한항알레르기효과를나타내므로, 알레르기성질환을효과적으로예방, 치료또는개선할수 있다.
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公开(公告)号：KR1020170049895A
公开(公告)日：2017-05-11
申请号：KR1020150150787
申请日：2015-10-29
Applicant: 동화약품주식회사
Abstract: 본발명은오미자를이용한스파클링발효음료제조방법에관한것이다. 본발명의오미자스파클링발효음료는이산화탄소를주입하거나탄산수와혼합하여제조되는기존의스파클링음료와달리자연스러운탄산감을가지고오미자발효향이강하여풍미가뛰어나다. 또한알코올발효를통해오미자특유의강한신맛이음료에적합한맛으로개질(改質)되어은은한떫은맛과상큼한뒷맛을가지며, 오미자고유의아름다운핑크빛색조를나타낸다. 뿐만아니라오미자발효액을포함하고있어우수한항산화효과, 피부주름예방효과, 항염증효과, 및항균효과를가진다.
Abstract translation: 本发明涉及使用omiza生产发泡饮料的方法。 与通过注入二氧化碳或与碳酸水混合制备的传统发泡饮料不同，本发明的奥米加发泡发酵饮料具有天然碳酸感和奥米加发酵的强烈风味。 此外，Omija的强酸性通过酒精发酵而改变，以改变适合饮料的风味，并且具有淡淡的刺痛味道和清爽的余味，呈现出Omija原始的美丽的粉红色调。 另外还具有优异的抗氧化效果，防止皮肤皱纹，抗炎效果和抗菌效果。
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公开(公告)号：KR2020160000220U
公开(公告)日：2016-01-20
申请号：KR2020140005227
申请日：2014-07-11
Applicant: 동화약품주식회사
Inventor： 박희범
CPC classification number: A46B9/026 , A46B3/02 , A46B5/026 , A46B9/005 , A46B2200/1073
Abstract: 본고안에따른틀니용칫솔은, 길이를갖는손잡이와, 상기손잡이의전단에형성되는헤드부와, 상기헤드부의상부설치면에일단이결합되며, 상기헤드부의전방으로경사지게배열되는다수의브러쉬및, 상기헤드부의하부설치면에일단이결합되며, 상기헤드부의전방으로경사지게설치되는스펀지를포함한다.
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公开(公告)号：KR1020140123264A
公开(公告)日：2014-10-22
申请号：KR1020130040342
申请日：2013-04-12
Applicant: 동화약품주식회사
IPC: A61K31/05 , A61K31/045 , A61K36/605 , A61P3/10
CPC classification number: A61K36/605 , A23L33/105 , A61K31/352
Abstract: The present invention relates to a pharmaceutical composition or health functional food comprising cathayanin B or kuwanol A, which are compounds isolated from morus bark, for preventing and treating diabetic complications. According to the present invention, the cathayanin B compound is isolated from the morus bark, and inhibits the creation of an advanced glycation end-product (AGE), which is a causative substance of diabetic complications, and aldose reductase activity. Thus, the pharmaceutical composition or health functional food, which comprises the cathayanin B or the kuwanol A, can be useful for inhibiting diabetic complications such as diabetic nephropathy, diabetic retinopathy and diabetic neuropathy. In particular, the kuwanol A can be used as the pharmaceutical composition for preventing and treating various fibrosis and cancer metastasis as well as the diabetic complications and also used as the health functional food for alleviating the same.
Abstract translation: 本发明涉及一种药物组合物或保健功能食品，其包含作为从桑树皮分离的化合物，用于预防和治疗糖尿病并发症的cathayanin B或kuwanol A。 根据本发明，从桑树皮中分离出cathayanin B化合物，抑制作为糖尿病并发症的致病物质的高级糖基化终产物（AGE）的产生和醛糖还原酶的活性。 因此，包含cathayanin B或kuwanol A的药物组合物或健康功能性食品可用于抑制糖尿病性肾病，糖尿病性视网膜病变和糖尿病性神经病变等糖尿病并发症。 特别地，可以将奎娃子A用作预防和治疗各种纤维化和癌症转移以及糖尿病并发症的药物组合物，并且也用作用于缓解其的健康功能性食品。
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公开(公告)号：KR1020120067819A
公开(公告)日：2012-06-26
申请号：KR1020100129430
申请日：2010-12-16
Applicant: 동화약품주식회사
IPC: C07D403/10 , A61K31/4184 , A61K31/4178 , A61P9/12
CPC classification number: Y02P20/55 , C07D403/10 , A61K31/4184
Abstract: PURPOSE: An improved method for preparing candesartan cilexetil is provided to simplify entire process under a mild condition. CONSTITUTION: A method for preparing candesartan cilexetil of chemical formula 1 comprises: a step of dissolving a compound of chemical formula 2 in a dichloromethane solution; a step of adding a mixture solution of alcohol and acetyl chloride to the dichloromethane solution; a step of deprotecting to remove triphenyl methane protection groups and obtain a compound of chemical formula 1; a step of adding ethyl acetate and n-hexane and precipitating the compound of chemical formula 1.
Abstract translation: 目的：提供一种改进的坎地沙坦替卡西汀的制备方法，以简化温和条件下的整个过程。 构成：制备化学式1的坎地沙坦酯的方法包括：将化学式2的化合物溶解在二氯甲烷溶液中的步骤; 将醇和乙酰氯的混合溶液加入到二氯甲烷溶液中的步骤; 去除三氯甲烷保护基并脱除化学式1化合物的步骤; 加入乙酸乙酯和正己烷并使化学式1的化合物沉淀的步骤。
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Patent Agency Ranking26.发明授权육두구 추출물을 유효성분으로 함유하는 비만 예방 및 치료용 약학조성물 有权用于治疗或预防肥胖症的药物组合物，其包含来自肉豆蔻（Myristica fragrans Houttuyn）的提取物
公开(公告)号：KR101018577B1
公开(公告)日：2011-03-03
申请号：KR1020080121296
申请日：2008-12-02
Applicant: 동화약품주식회사
Abstract: 본 발명은 육두구 추출물을 유효성분으로 함유하는 비만 예방 및 치료용 약학 조성물에 관한 것이다.
본 발명은 육두구 추출물에 의해서 고지방 식이의 섭취로 인하여 유발되는 체중증가 억제, 난소주위 지방중량 증가억제 및 주로 지방 세포의 비대에 의해 초래되는 복부지방의 축적을 억제함으로써, 고지방 식이의 섭취에 의해 유발되는 비만 예방 및 치료용 약학조성물로 유용하게 이용될 수 있다.
육두구, 비만-
公开(公告)号：KR101011333B1
公开(公告)日：2011-01-28
申请号：KR1020060009292
申请日：2006-01-31
Applicant: 동화약품주식회사
IPC: A61K36/488 , A61K36/237 , A61K36/9068 , A61P13/12
CPC classification number: A61K36/25 , A61K36/488 , A61K36/60 , A61K2300/00
Abstract: 본 발명은 생약재 갈근(Puerariae Radix), 백강잠(Bombycis corpus) 또는 독활(Araliae Continentalis Radix)중에서 1 이상 선택되는 생약 추출물을 함유하는 의약 및 건강기능식품에 관한 것이다. 본 발명에 따른 생약재는 독립적으로 또는 혼합조성물로 하여 신장질환 예방 및 치료 또는 신장기능 개선을 위해 유용하게 이용될 수 있다.
갈근, 백강잠, 독활, 신장질환-
28.发明公开
公开(公告)号：KR1020100067047A
公开(公告)日：2010-06-18
申请号：KR1020090119520
申请日：2009-12-04
Applicant: 동화약품주식회사
IPC: C07D213/72 , C07D213/64 , A61K31/44 , A61P19/10
CPC classification number: C07D213/74 , A61K31/4439 , C07D401/14
Abstract: PURPOSE: A 2,6-site-substituted 3-nitropyridine derivative compound is provided to suppress formation of osteroclast and to use in preventing and treating osteroporosis. CONSTITUTION: A novel 2,6-substituted 3-nitro derivative compound is denoted by chemical formula 1. A method for manufacturing the 2,6-substituted 3-nitro derivative compound comprises: a step of reating 2,6-dichloro-3-nitropyridine and 5-aminoindazole under the presence of base to prepare 2(1H-indazole-5-yl)amino-6-chloro-3-nitropyridine; and a step of reacting an amine compound of 2-methyl-2-imidazoline, 2-methyl imidazole, 2-isopropylimidazol, or 5-methyl imidazole with 2(1H-indazole-5-yl)amion-6-chloro-3-nitropyridine. A composition for preventing or treating osteoporosis contains the 3-nitropyridine derivative compound or salt thereof.
Abstract translation: 目的：提供2,6-位取代的3-硝基吡啶衍生物化合物，以抑制成骨细胞的形成并用于预防和治疗卵巢疏松症。 构成：新的2,6-取代的3-硝基衍生物化合物由化学式1表示。制备2,6-取代的3-硝基衍生物化合物的方法包括：将2,6-二氯-3- 硝基吡啶和5-氨基吲唑在碱存在下反应制备2（1H-吲唑-5-基）氨基-6-氯-3-硝基吡啶; 和2-甲基-2-咪唑啉，2-甲基咪唑，2-异丙基咪唑或5-甲基咪唑的胺化合物与2（1H-吲唑-5-基）氨基-6-氯-3- 硝基吡啶。 用于预防或治疗骨质疏松症的组合物含有3-硝基吡啶衍生物化合物或其盐。
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29.发明公开
公开(公告)号：KR1020100067046A
公开(公告)日：2010-06-18
申请号：KR1020090119519
申请日：2009-12-04
Applicant: 동화약품주식회사
IPC: C07D213/16 , C07D213/53 , A61K31/44 , A61P19/10
CPC classification number: C07D213/74 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
Abstract: PURPOSE: A 3-nitropyridine derivative compound which is substituted at 2,6-site is provided to suppress differentiation of osteoclast and to prevent and treat osteoporosis. CONSTITUTION: A 3-nitropyridine derivative compound which is substituted at 2,6-site is denoted by chemical formula 1. A method for preparing the 3-nitropyridine derivative compound comprises: a step of reacting aniline compound of chemical formula 3 with 2,6-dichloro-3-nitropyridine under the presence of base to obtain a 6-chloro-3-nitropyridine derivative compound of chemical formula 4; and a step of reacting amine compound of chemical formula 5 with a compound of chemical formula 4 to obtain the 3-nitropyridine derivative compound. A pharmaceutical composition for preventing or treating osteoporosis contains the 3-nitropyridine derivative or pharmaceutically acceptable salt as an active ingredient.
Abstract translation: 目的：提供在2,6位取代的3-硝基吡啶衍生物化合物，以抑制破骨细胞的分化和预防和治疗骨质疏松症。 构成：在2,6-位取代的3-硝基吡啶衍生物化合物由化学式1表示。制备3-硝基吡啶衍生物化合物的方法包括：使化学式3的苯胺化合物与2,6- - 二氯-3-硝基吡啶在碱存在下反应，得到化学式4的6-氯-3-硝基吡啶衍生物化合物; 和使化学式5的胺化合物与化学式4的化合物反应以获得3-硝基吡啶衍生物化合物的步骤。 用于预防或治疗骨质疏松症的药物组合物含有3-硝基吡啶衍生物或药学上可接受的盐作为活性成分。
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30.发明公开고지혈증 치료시 유발되는 간 손상 예방 및 간 기능 개선을위한 정향 추출물 함유 기능성식품 有权包含来自EUGENIA CARYOPHYLLATA的提取物的功能性食品改善和预防治疗高脂血症导致的肝损伤症状
公开(公告)号：KR1020100064816A
公开(公告)日：2010-06-15
申请号：KR1020080123424
申请日：2008-12-05
Applicant: 동화약품주식회사
CPC classification number: A23L33/40 , A23L33/105 , A23V2002/00 , A23V2200/30 , A23V2200/3262 , A23V2250/21
Abstract: PURPOSE: Functional food containing eugenia caryophyllata extract is provided to protect tissue of liver while restricting enzyme activity of alanine aminotransferase and aspartate aminotransferase in blood, and to restrict accumulation of fat in liver. CONSTITUTION: Functional food preventing liver damage caused by high fat and improving liver function contains eugenia caryophyllata extract. The functional food further contains mixed herbal mixtures of cinnamomi Cortex, myristicae Semen, gambir, aurantii nobilis Pericarpium, atractylodis Rhizoma, magnoliae Cortex, corydalis Tuber and Capsicum annuum. The function food further contains a mixed herb extract mixture.
Abstract translation: 目的：提供维生素Eugenia caryophyllata提取物的功能食品，以保护肝组织，同时限制血液中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的酶活性，并限制脂肪在肝脏中的积累。 构成：功能性食物防止高脂肪引起的肝脏损伤，改善肝功能，含有金丝桃提取物。 功能性食品还含有肉桂肉皮，肉豆蔻，甘草，高粱，白术，白术，紫堇和辣椒的混合草药混合物。 功能食物还含有混合草药提取物混合物。
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