Abstract:
A composition comprising extracts of crude drugs is provided to suppress and relieve itching caused by inflammatory and atopic dermatitis without side effects such as toxicity and skin irritation. A composition for suppressing and relieving itching comprises 0.1-10 wt.% of the extracts of Zingiber officinale Rosc., Evodia officinalis and Alpinia katsumadai Hayata which are prepared by extracting them with water, C1-C4 lower alcohol or a mixed solvent thereof. The daily dosage of crude drug extracts is 0.001-100 mg/kg, preferably 0.1-30 mg/kg and the composition is a pharmaceutical composition having a formulation selected from ointment, plaster, lotion and liniment, or a cosmetic composition having a formulation selected from skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.
Abstract:
2,2-Dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives and PGE2(prostagrandine E2) production inhibitors containing the same compounds as an effective ingredient are provided to treat diseases associated with the activity of PGE2 by suppressing inflammation caused by PGE2. The 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives represented by the formula(1) or their pharmaceutically acceptable salts are provided, wherein R^1 and R^2 are identical or different, and are each independently C1-C10 linear, branched or cyclic alkyl group, optionally substituted benzyl group or penethyl group; and R^3 is hydrogen, C1-C10 alkyl group, C2-C10 alkenyl group, C2-C10 alkynyl group, optionally substituted benzyl group or naphthylmethyl group. The PGE2 production inhibitors contain 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives represented by the formula(1) or their pharmaceutically acceptable salts as effective ingredient.
Abstract:
본 발명은 스핑고실포스포릴콜린(Sphingosylphosphorylcholine; SPC) 또는 그 유도체의 용도에 관한 것으로서, 보다 상세하게는 상기 스핑고실포스포릴콜린의 투여량을 조절하여 동물에 가려움을 유발하는 방법, 가려움증 억제 물질을 스크리닝하는 방법 및 스크리닝한 가려움증 억제 물질의 약효를 평가하는 방법에 관한 것이다. 본 발명에 의한 스핑고실포스포릴콜린 또는 그 유도체는 가려움증을 이해하고 연구하는데 유용하며, 이를 바탕으로 가려움증 치료 약을 검색하거나 약효를 평가하여 개발하는데 매우 유용하게 사용될 수 있다. 가려움증, 스핑고실포스포릴콜린, 가려움증 억제 물질
Abstract:
본 발명은 소자 (Perillae Semen), 우방자 (Arctii Semen) 및 초두구 (Alpiniae Katsumadaii Semen) 로 이루어진 군에서 선택된 1종 이상; 및 당귀 (Angelicae Gigantis Radix) 및 부평초 (Spirodelae Herba) 추출물로 이루어진 군에서 선택된 1종 이상의 식물 추출물을 함유하는 피부 외용제 조성물로서, IgE 매개성 알러지 반응 억제 능력에 의해 아토피성 피부염, 접촉성 피부염, 건선 등의 피부질환을 치료 또는 예방하기 위해 사용될 수 있다. 소자, 우방자, 초두구, 당귀, 부평초, 면역반응 억제, 아토피성 피부염, 접촉성 피부염, 건선
Abstract:
PURPOSE: A skin external composition is provided to suppress abnormally activated T lymphocyte-mediated immune response and to treat or prevent atopic dermatitis, contact dermatitis and psoriasis. CONSTITUTION: A cosmetic composition for relieving T lymphocyte-mediated skin immune disorder contains 0.001-10 weight% of Dalbergiae odoriferae lignum extract as an active ingredient. A pharmaceutical composition for treating T lymphocyte-mediated skin immune disorder contains Dalbergiae odoriferae lignum extract as an active ingredient.
Abstract:
PURPOSE: A skin external composition is provided to suppress abnormally activated T lymphocyte-mediated immune response and relieve atopic dermatitis, contact dermatitis, and psoriasis. CONSTITUTION: A cosmetic composition for relieving T lymphocyte-mediated dermal immune diseases contains Dendrobii herba extract as an active ingredient. The dermal immune diseases include atopic dermatitis, contact dermatitis, or psoriasis. A pharmaceutical composition for relieving T lymphocyte-mediated dermal immune disease contains the Dendrobii herba extract as an active ingredient.