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    2,2-디메틸-3-알킬에테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 PGE2 활성에 관련된 염증질환 치료제
    1.
    发明公开
    2,2-디메틸-3-알킬에테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 PGE2 활성에 관련된 염증질환 치료제 有权
    含有2,2-二甲基-3-烷基-4-烷氧基-6-烷基氨基苯甲酰基衍生物的2,2-二甲基-3-烷基-4-烷氧基-6-烷基氨基苯并噻吩衍生物和PGE2生产抑制剂作为有效成分

    公开(公告)号：KR1020060123000A

    公开(公告)日：2006-12-01

    申请号：KR1020050045294

    申请日：2005-05-28

    Applicant: 한국화학연구원 ,  (주)아모레퍼시픽

    Inventor： 공영대 ,  이일영 ,  이종철 ,  조희영 ,  황종연 ,  최형섭 ,  전현숙 ,  유성은 ,  이창훈 ,  성대석 ,  김광미 ,  김대권 ,  양혜진 ,  김형준 ,  박종희 ,  심영철

    IPC: C07D311/22 ,  C07D311/24

    CPC classification number: C07D311/22

    Abstract: 2,2-Dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives and PGE2(prostagrandine E2) production inhibitors containing the same compounds as an effective ingredient are provided to treat diseases associated with the activity of PGE2 by suppressing inflammation caused by PGE2. The 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives represented by the formula(1) or their pharmaceutically acceptable salts are provided, wherein R^1 and R^2 are identical or different, and are each independently C1-C10 linear, branched or cyclic alkyl group, optionally substituted benzyl group or penethyl group; and R^3 is hydrogen, C1-C10 alkyl group, C2-C10 alkenyl group, C2-C10 alkynyl group, optionally substituted benzyl group or naphthylmethyl group. The PGE2 production inhibitors contain 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyrane derivatives represented by the formula(1) or their pharmaceutically acceptable salts as effective ingredient.

    Abstract translation: 提供含有相同化合物作为有效成分的2,2-二甲基-3-烷基醚-4-烷氧基-6-烷基氨基苯并吡喃衍生物和PGE2（前列腺素E2）产生抑制剂，用于通过抑制炎症来治疗与PGE2的活性相关的疾病 由PGE2引起。 提供由式（1）表示的2,2-二甲基-3-烷基醚-4-烷氧基-6-烷基氨基苯并吡喃衍生物或其药学上可接受的盐，其中R 1和R 2相同或不同，和 各自独立地为C 1 -C 10直链，支链或环状烷基，任选取代的苄基或苯乙基; R 3为氢，C 1 -C 10烷基，C 2〜C 10烯基，C 2〜C 10炔基，任意取代的苄基或萘甲基。 PGE 2生成抑制剂含有式（1）表示的2,2-二甲基-3-烷基醚-4-烷氧基-6-烷基氨基苯并吡喃衍生物或其药学上可接受的盐作为有效成分。

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