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公开(公告)号：EP2064336A4
公开(公告)日：2010-03-17
申请号：EP07873427
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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公开(公告)号：SG2014010029A
公开(公告)日：2014-08-28
申请号：SG2014010029
申请日：2006-08-18
Applicant: ABBOTT LAB , ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：CA2618482C
公开(公告)日：2014-10-07
申请号：CA2618482
申请日：2006-08-18
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：CA2644910C
公开(公告)日：2014-01-28
申请号：CA2644910
申请日：2007-04-02
Applicant: ABBOTT LAB
Inventor： ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
IPC: A61K31/5377
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
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公开(公告)号：NZ597168A
公开(公告)日：2013-07-26
申请号：NZ59716806
申请日：2006-08-18
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
IPC: A61K38/00 , A61K31/192 , A61K31/343 , A61K31/365 , A61K31/4152 , A61K31/445 , A61K31/496 , A61K31/551 , A61K31/60 , A61K39/395 , A61K49/00 , A61K49/14 , A61K49/16
Abstract: 597168 DUAL VARIABLE DOMAIN IMMUNOGLOBIN AND USES THEREOF Provided is a binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first immunoglobulin heavy chain variable domain, VD2 is a second immunoglobulin heavy chain variable domain, C is an immunoglobulin constant domain, X1 is a linker with the proviso that it is not an immunoglobulin constant domain, and X2 is an Fc region; and said second polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first immunoglobulin light chain variable domain, VD2 is a second immunoglobulin light chain variable domain, C is an immunoglobulin constant domain, X1 is a linker with the proviso that it is not an immunoglobulin constant domain, and X2 is an Fc region; wherein n is 0 or 1; and wherein the first and second polypeptide chains form two functional antigen binding sites.
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Patent Agency Ranking
公开(公告)号：CR20130154A
公开(公告)日：2013-05-23
申请号：CR20130154
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： LACY SUSAN E , FUNG EMMA , BELK JONATHAN P , DIXON RICHARD W , ROGUSKA MICHAEL , HINTON PAUL R , KUMAR SHANKAR
IPC: C07K16/00
Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo. También se provee un método de elaboración y un método de uso de los anticuerpos de la invención.
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公开(公告)号：CR20130152A
公开(公告)日：2013-05-23
申请号：CR20130152
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： LACY SUSAN E , FUNG EMMA , BELK JONATHAN P , DIXON RICHARD W , ROGUSKA MICHAEL , HINTON PAUL R , KUMAR SHANKAR
IPC: C07K16/00
Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo.
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公开(公告)号：CR20130151A
公开(公告)日：2013-05-23
申请号：CR20130151
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： LACY SUSAN E , FUNG EMMA , BELK JONATHAN P , DIXON RICHARD W , ROGUSKA MICHAEL , HINTON PAUL R , KUMAR SHANKAR
IPC: C07K16/00
Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados.
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公开(公告)号：AU2012205249A1
公开(公告)日：2012-08-09
申请号：AU2012205249
申请日：2012-07-19
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Abstract: DUAL VARIABLE DOMAIN IMMUNOGLOBIN AND USES THEREOF The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：AU2011201536A1
公开(公告)日：2011-04-28
申请号：AU2011201536
申请日：2011-04-05
Applicant: ABBOTT LAB
Inventor： DUNCAN ALEXANDER ROBERT , LABKOVSKY BORIS , SHORROCK CELIA ELIZABETH , SALFELD JOCHEN , MANKOVICH JOHN , ELIZABETH THOMPSON JULIA , WHITE MICHAEL , ROGUSKA MIKE , DIXON RICHARD W , BROCKLEHURST SIMON MARK , LENNARD SIMON NICHOLAS , GHAYUR TARIQ
IPC: C12N15/02 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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