公开(公告)号：CA2022444C

公开(公告)日：2002-01-15

申请号：CA2022444

申请日：1990-08-01

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN

IPC: A61K38/04 ,  A61K38/00 ,  C07K1/06 ,  C07K1/113 ,  C07K7/23 ,  C07K14/575 ,  A61K38/09

Abstract: The present invention relates to novel "pseudo" nonapeptide and decapeptide derivatives of LHRH. More particularly the present invention relates to derivatives of LHRH wherein the nitrogen atom of at least one of the amide bonds has been alkylated.

公开(公告)号：DE69330838D1

公开(公告)日：2001-10-31

申请号：DE69330838

申请日：1993-12-14

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  SWENSON ROLF E ,  SAUER DARYL R

IPC: A61K38/04 ,  A61K38/00 ,  A61P15/00 ,  C07K7/06 ,  C07K7/23 ,  A61K38/09 ,  A61K38/24

Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

公开(公告)号：CA2376073A1

公开(公告)日：2001-02-15

申请号：CA2376073

申请日：2000-08-09

Applicant: ABBOTT LAB

Inventor： JONES RONALD B ,  MUCHMORE STEVEN W ,  NIENABER VICKI L ,  PAN JEFFREY Y ,  GREER JONATHAN ,  OLSON JEFFREY A

IPC: G01N23/207 ,  G01N23/20 ,  G01N35/00

Abstract: Method and apparatus for mounting a sample comprising a crystal for X-ray crystallographic analysis, a method for aligning a sample comprising a cryst al for X-ray crystallographic analysis, which sample is mounted on a positionin g device, and a method for determining the structure of a sample containing a crystal by means of X-ray crystallography.

公开(公告)号：TR200002572T2

公开(公告)日：2000-11-21

申请号：TR200002572

申请日：1999-03-05

Applicant: ABBOTT LAB

Inventor： NIENABER VICKI L ,  GREER JONATHAN ,  ABAD-ZAPATERO CELERINO ,  NORBECK DANIEL W

IPC: G01N33/50 ,  G01N23/20 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  G01N33/00

公开(公告)号：NO20004807D0

公开(公告)日：2000-09-26

申请号：NO20004807

申请日：2000-09-26

Applicant: ABBOTT LAB

Inventor： SAUER DARYL R ,  HAVIV FORTUNA ,  RANDOLPH JOHN ,  MORT NICHOLAS A ,  DALTON CHRISTOPHER ROBIN ,  BRUNCKO MILAN ,  KAMINSKI MICHELE A ,  CRAWFORD BRADLEY W ,  FREY LISA MARIE ,  GREER JONATHAN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P5/00 ,  A61P15/00 ,  A61P43/00 ,  C07H17/08 ,  C07H

Abstract: Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

公开(公告)号：AU2987899A

公开(公告)日：1999-09-20

申请号：AU2987899

申请日：1999-03-05

Applicant: ABBOTT LAB

Inventor： NIENABER VICKI L ,  GREER JONATHAN ,  ABAD-ZAPATERO CELERINO ,  NORBECK DANIEL W

IPC: G01N33/50 ,  G01N23/20 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  G01N33/00

公开(公告)号：PT94924A

公开(公告)日：1991-05-22

申请号：PT9492490

申请日：1990-08-06

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN

IPC: A61K38/00 ,  C07K1/06 ,  A61K38/04 ,  C07K1/113 ,  C07K7/23 ,  C07K14/575 ,  C07K7/06 ,  A61K37/02

Abstract: The present invention relates to novel "pseudo" nonapeptide and decapeptide derivatives of LHRH. More particularly the present invention relates to derivatives of LHRH wherein the nitrogen atom of at least one of the amide bonds has been alkylated.

公开(公告)号：HU904911D0

公开(公告)日：1991-01-28

申请号：HU491190

申请日：1990-08-06

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  PALABRICA CHRISTOPHER A ,  FITZPATRICK TIMOTHY D

IPC: A61K38/04 ,  A61K38/00 ,  A61P5/00 ,  C07K1/06 ,  C07K7/23 ,  C07K14/575

Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.

公开(公告)号：PT683792E

公开(公告)日：2002-03-28

申请号：PT94905391

申请日：1993-12-14

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  SWENSON ROLF E ,  SAUER DARYL R

IPC: A61K38/00 ,  A61P15/00 ,  C07K7/06 ,  C07K7/23 ,  A61K38/04 ,  A61K38/09 ,  A61K38/24

Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

公开(公告)号：AT206136T

公开(公告)日：2001-10-15

申请号：AT94905391

申请日：1993-12-14

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  SWENSON ROLF E ,  SAUER DARYL R

IPC: A61K38/04 ,  A61K38/00 ,  A61P15/00 ,  C07K7/06 ,  C07K7/23 ,  A61K38/09 ,  A61K38/24

Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.