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21.发明专利
公开(公告)号：SK285411B6
公开(公告)日：2007-01-04
申请号：SK141699
申请日：1998-04-17
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAK EDWARD T
IPC: G01N24/00 , G01R33/32 , A61K45/00 , C07K14/705 , C12N9/00 , C12Q1/00 , C12Q1/68 , G01N24/08 , G01N33/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01R33/44
Abstract: The present invention provides a process for identifying compounds, which bind to a specific target molecule. The process comprises the steps of: a) generating the first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating the second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed to the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.
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公开(公告)号：AT327510T
公开(公告)日：2006-06-15
申请号：AT00918228
申请日：2000-03-21
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J
IPC: G01N24/12 , B08B9/04 , C07K1/13 , E21B37/04 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/542 , G01N33/566 , G01N33/68 , G01N33/94 , G01R33/46 , G01R33/465 , C07B61/00 , G01N33/58
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公开(公告)号：HK1058031A1
公开(公告)日：2004-04-30
申请号：HK03108723
申请日：2003-11-28
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL A
IPC: C07C20060101 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D20060101 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
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公开(公告)号：AU2003268178A1
公开(公告)日：2004-03-11
申请号：AU2003268178
申请日：2003-08-25
Applicant: ABBOTT LAB
Inventor： HAJDUK PHILIP J , BEUTEL BRUCE A , DANDLIKER PETER J
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公开(公告)号：AT259061T
公开(公告)日：2004-02-15
申请号：AT98918461
申请日：1998-04-17
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAK EDWARD T
IPC: G01R33/32 , A61K45/00 , C07K14/705 , C12N9/00 , C12Q1/68 , G01N24/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01R33/44
Abstract: The present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating a second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.
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Patent Agency Ranking
公开(公告)号：DK0870197T3
公开(公告)日：2001-08-27
申请号：DK96939709
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAK EDWARD T
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公开(公告)号：CO5060446A1
公开(公告)日：2001-07-30
申请号：CO98020602
申请日：1998-04-15
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAK EDWARD T
IPC: G01R33/32 , A61K38/00 , A61K45/00 , C07K14/705 , C12N9/00 , C12Q1/68 , G01N24/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01R33/44
Abstract: Un proceso de selección de compuestos para identificarcompuestos que son ligandos que se enlazan a una molécula señalada específica comprende las etapas de:a) Generación de un primer espectro unidimensional T2 - o de difusión filtrada de uno a una mezcla de compuestos químicos; b) exposición del compuesto o mezcla de compuestos químicos a la molécula señalada;c) generación de un segundo espectro unidimensional T2 - o de difusión filtrada de uno o una mezcla de compuestos químicos que han sido expuestos a la molécula señalada (b); yd) comparación del mencionado primero y segundo espectro T2 - o de difusión filtrada para determinar las diferencias entre los mencionados primero y segundos espectros, las diferencias identifican la presencia de uno o más ligandos que se han enlazado a la molécula señalada.
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公开(公告)号：BR9808079A
公开(公告)日：2000-03-08
申请号：BR9808079
申请日：1998-04-17
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAC EDWARD T
IPC: G01R33/32 , A61K45/00 , C07K14/705 , C12N9/00 , C12Q1/68 , G01N24/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01R33/44
Abstract: The present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating a second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.
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公开(公告)号：NO995078A
公开(公告)日：1999-12-06
申请号：NO995078
申请日：1999-10-18
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J , OLEJNICZAK EDWARD T
IPC: G01R33/32 , A61K45/00 , C07K14/705 , C12N9/00 , C12Q1/68 , G01N24/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01R33/44 , G01N
CPC classification number: G01R33/44 , G01N24/08 , G01N33/6803 , G01N2500/20 , Y10S435/81
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公开(公告)号：AU701810B2
公开(公告)日：1999-02-04
申请号：AU7732896
申请日：1996-11-13
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , HAJDUK PHILIP J
IPC: G01R33/465 , C12Q1/00 , G01N20060101 , G01N24/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/542 , G01N33/566 , G01N33/58 , G01N33/68
Abstract: A method for designing and forming a ligand which binds to a specific target molecule comprises the steps of: (a) identifying a first ligand moiety that binds to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (b) identifying subsequent ligand moieties that bind to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (c) forming a complex of the first and subsequent ligand moieties to the target molecule; (d) determining the three-dimensional structure of the complex and, thus, the spatial orientation of the first and subsequent ligand moieties on the target molecule; and (e) linking the first and subsequent ligand moieties to form a new ligand to maintain the spatial orientation of the ligand moieties.
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