公开(公告)号：DE602004017329D1

公开(公告)日：2008-12-04

申请号：DE602004017329

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：BRPI0518581A2

公开(公告)日：2008-11-25

申请号：BRPI0518581

申请日：2005-11-22

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR R ,  BAYBURT EROL K ,  SCHMIDT ROBERT G ,  LEE CHIH-HUNG ,  BROWN BRIAN S ,  JINKERSON TAMMIE K ,  KOENIG JOHN R ,  DAANEN JEROME F ,  LATSHAW STEVE

IPC: C07D405/12 ,  C07D401/12 ,  C07D403/12

Abstract: Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt thereof, wherein A 1 , A 2 , A 3 , A 4 , R 7 , R 8 , R 9 , X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

公开(公告)号：MX2008013428A

公开(公告)日：2008-11-04

申请号：MX2008013428

申请日：2007-04-12

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  KOENIG JOHN R ,  BROWN BRIAN S ,  GOMTSYAN ARTHUR R

IPC: A61K31/519 ,  A61K31/4747 ,  C07D498/10

Abstract: La presente invención se refiere a compuestos de fórmula (I) en donde las variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, y A4 son como se definen en la memoria descriptiva, y métodos de uso para tratar dolor, dolor neuropático, alodinia, dolor asociado con inflamación o una enfermedad inflamatoria, hiperalgesia inflamatoria, hiperactividad vesical, e incontinencia urinaria. (ver fórmula (I)).

公开(公告)号：MXPA06001396A

公开(公告)日：2007-02-13

申请号：MXPA06001396

申请日：2004-08-04

Applicant: ABBOTT LAB

Inventor： BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  ZHENG GUO ZHU ,  TURNER SEAN C ,  WHITE TAMMIE K ,  DIDOMENICO STANLEY JR ,  DRIZIN IRENE ,  GOMTSYAN ARTHUR R ,  PENNER RICHARD J ,  SCHMIDT ROBERT G JR

IPC: C07D217/24 ,  A61K31/5377 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/26 ,  C07D231/56 ,  C07D237/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D451/02 ,  C07D521/00

Abstract: Ver formula (I) Los compuestos de la Formula (I) son novedosos antagonistas de VR1, que son utiles en el tratamiento de dolor, hiperalgesia termica inflamatoria, incontinencia urinaria, e hiperactividad de la vejiga.

公开(公告)号：ZA200509861B

公开(公告)日：2006-12-27

申请号：ZA200509861

申请日：2005-12-05

Applicant: ABBOTT LAB

Inventor： ARTHUR GOMTSYAN ,  CHIN-HUNG LEE ,  ROBERT SCHMIDT ,  GILLES CHAMBOUMIER ,  ROBERT LEANNA M ,  BAYBURT EROL K ,  KOENIG JOHN R ,  KIRILL LUKIN ,  MARGARET HSU ,  CINK RUSSEL D

IPC: A61K20090101 ,  A61P20090101 ,  C07C20090101 ,  C07D20090101 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：CA2590711A1

公开(公告)日：2006-06-15

申请号：CA2590711

申请日：2005-12-07

Applicant: ABBOTT LAB

Inventor： PERNER RICHARD J ,  BROWN BRIAN S ,  LEE CHIH-HUNG ,  KEDDY RYAN G ,  KOENIG JOHN R

IPC: C07D471/04 ,  A61K31/519 ,  A61P13/00 ,  A61P13/10 ,  A61P29/00 ,  C07D519/00

Abstract: Compounds having formula (I) or formula (II) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R 1 , R 2 and R 3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.

公开(公告)号：CA2532057A1

公开(公告)日：2005-01-27

申请号：CA2532057

申请日：2004-07-09

Applicant: ABBOTT LAB

Inventor： WHITE TAMMIE K ,  SCHMIDT ROBERT G ,  TURNER SEAN C ,  BROWN BRIAN S ,  KOENIG JOHN R ,  LEE CHIH-HUNG ,  ZHENG GUO ZHU

IPC: C07D401/04 ,  A61K31/4525 ,  A61K31/4995 ,  A61P25/04 ,  C07D401/12 ,  C07D487/08

Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7an d R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

公开(公告)号：CA2526872A1

公开(公告)日：2004-12-23

申请号：CA2526872

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： SCHMIDT ROBERT ,  BAYBURT EROL K ,  KOENIG JOHN R ,  LEE CHIH-HUNG ,  HSU MARGARET ,  LEANNA ROBERT M ,  CHAMBOURNIER GILLES ,  LUKIN KIRILL ,  CINK RUSSELL D ,  GOMTSYAN ARTHUR

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：CA2526872C

公开(公告)日：2013-02-05

申请号：CA2526872

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA ROBERT M ,  CINK RUSSELL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 -R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：NZ590234A

公开(公告)日：2012-07-27

申请号：NZ59023404

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D ,  BAYBURT EROL K

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: A process for preparing a compound having structural formula (1*), wherein the substituents are as defined in the specification is disclosed, wherein process (1) is a process comprising, in toto, the steps of: (a) treating a compound of formula (XII) with trichloroacetyl chloride and triethylamine in dichloromethane to provide a compound of formula (la); and (b) treating the compound of formula (la) with a compound formula (XIII) (shown in the specification) and 1,8-diazabicycloundec-7-ene (DBU) in acetonitrile to provide a compound of formula (1*). Also disclosed are alternate processes for preparing a compound of formula (1*). These compounds of formula (1*) inhibit the VR1 receptor in mammals and are useful for controlling pain.