公开(公告)号：EP2590671A4

公开(公告)日：2013-12-18

申请号：EP11804385

申请日：2011-07-08

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN

IPC: A61K39/00 ,  C07K16/22 ,  C07K16/28 ,  C07K16/46 ,  C12N5/07 ,  C12N5/16 ,  C12P21/08

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  C07K16/22 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6872

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法，特别是它们在疾病的预防，诊断和/或治疗中的用途。

公开(公告)号：EP2459729A4

公开(公告)日：2013-04-24

申请号：EP10805046

申请日：2010-07-29

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/46 ,  G01N33/68

CPC classification number: C07K16/468 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  G01N33/6854

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：EP2493924A4

公开(公告)日：2013-05-29

申请号：EP10830460

申请日：2010-10-28

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  SALFELD JOCHEN G ,  MCPHERSON MICHAEL J ,  HARRIS MARIA C ,  LIU JUNJIAN ,  ISAKSON PETER C ,  GU JIJIE

IPC: C07K16/46 ,  A61K39/395 ,  C07K16/22 ,  C07K16/28

CPC classification number: C07K16/241 ,  C07K16/22 ,  C07K16/2803 ,  C07K16/2875 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/73

公开(公告)号：EP2473524A4

公开(公告)日：2013-05-22

申请号：EP10814433

申请日：2010-09-01

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  MANOJ SHARMILA ,  BROPHY SUSAN E

IPC: C07K16/00 ,  C07H21/00

CPC classification number: C07K16/468 ,  A61K45/06 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/515 ,  C07K2317/64 ,  C07K2317/732 ,  C07K2317/92

公开(公告)号：EP2282769A4

公开(公告)日：2012-04-25

申请号：EP09739578

申请日：2009-04-28

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

IPC: C07K16/28 ,  C07K16/46

CPC classification number: C07K16/468 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/515 ,  G01N2333/705 ,  Y10S435/81

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：BR112012002095A2

公开(公告)日：2015-09-01

申请号：BR112012002095

申请日：2010-07-29

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  IBRAGHIMOV ALEXANDER

IPC: C12P21/08

公开(公告)号：MX2013004979A

公开(公告)日：2013-07-30

申请号：MX2013004979

申请日：2011-11-01

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  GU JIJIE ,  HARRIS MARIA C

IPC: C12P21/08 ,  A61K39/395 ,  C07K16/00

Abstract: Se proporcionan proteínas de unión multivalentes y multiespecíficas diseñadas por ingeniería, métodos para elaborarlas y sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.

公开(公告)号：SG190572A1

公开(公告)日：2013-06-28

申请号：SG2013030655

申请日：2009-04-28

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：SG188944A1

公开(公告)日：2013-05-31

申请号：SG2012094900

申请日：2011-06-23

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  JAKWAY JAMES J ,  TALANIAN ROBERT V ,  BENATUIL LORENZO

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：NZ588554A

公开(公告)日：2013-03-28

申请号：NZ58855409

申请日：2009-04-28

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

IPC: A61K39/00

Abstract: Disclosed is a binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; n is 0 or 1. Furthermore, the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site and are as defined in the specification. The disclosed binding protein is capable of binding to VEGF with an EC50 of at most about 28.25 nM, as measured by direct bind ELISA, and/or the binding protein is capable of binding to DLL4 with an EC50 of at most about 2.12nM, as measured by direct bind ELISA.