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公开(公告)号：JPS61224932A
公开(公告)日：1986-10-06
申请号：JP6766885
申请日：1985-03-30
Applicant: AGENCY IND SCIENCE TECHN , NITTO ELECTRIC IND CO
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO , NINOMIYA YASUO , HIGUCHI TOSHIO
Abstract: PURPOSE:Gamma-linoleic acid or its ester is added to conventional powder or liquid milk to give a high-quality product having nutrient composition similar to mother's milk whereby health troubles which have been observed, when conventional milk is given, are prevented. CONSTITUTION:Gamma-linoleic acid or its ester is added to powdered milk in an amount of 0.01-1wt% on the solid basis or to liquid milk in an amount of 0.001-0.1wt%. The alkyl group of the ester is preferably methyl or ethyl. In order to admix the gamma-linoleic acid or its ester to powdered or liquid milk uniformly in the stabilized state, the acid or ester is preferably clathrated and the clathrate is added thereto.
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公开(公告)号：JPS6157693A
公开(公告)日：1986-03-24
申请号：JP9862085
申请日：1985-05-09
Applicant: Agency Ind Science Techn
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO
IPC: C10C3/10 , C07C69/587 , C11C3/10 , C12P7/64 , C12R1/645
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公开(公告)号：JPH06345666A
公开(公告)日：1994-12-20
申请号：JP16379693
申请日：1993-06-10
Applicant: AGENCY IND SCIENCE TECHN , MAEKAWA SEISAKUSHO KK
Inventor： MITSUI YOJI , SUZUKI OSAMU , ITOU TAKEHIRO
Abstract: PURPOSE:To obtain a hepatic function improving agent exhibiting hepatocyte activating and proliferating activity by using a human-originated cornified epidermal cell proliferation factor as an active component. CONSTITUTION:The improving agent contains 0.1-0.5wt.% of a cornified epidermal cell proliferation factor as an active component. The factor is a proteinous proliferation factor refined by using a proliferation activity from a human fetus fibroblast cell culture liquid to a cornified epidermal cell of mouse as an index. The agent is properly compounded with ordinary carrier for pharmaceutical preparation and formed in the form of injection, peroral drug or enteral administration drug. It is administered at a daily dose of 1-100mg for adult. The agent exhibits hepatocyte proliferation stimulating activity higher than known hepatocyte proliferation factor without causing the risk of the aggravation of a highly fibrillated state such as hepatic cirrhosis.
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公开(公告)号：JPH05302087A
公开(公告)日：1993-11-16
申请号：JP13204492
申请日：1992-04-24
Applicant: AGENCY IND SCIENCE TECHN
Inventor： YOKOYAMA SHINYA , TSUCHIDE YUTAKA , SAWAYAMA SHIGEKI , MINOWA TOMOAKI , YOKOCHI TOSHIHIRO , KAMISAKA YASUSHI , NAKAHARA HARUROU , SUZUKI OSAMU
Abstract: PURPOSE:To provide a method by which a cell which accumulates oil or fat is liquefied simply and effectively to give a substance like heavy oil and simultaneously bring the liquefaction product into a state with good phase separation properties. CONSTITUTION:A cell which accumulates oil or fat is kept at high temp. and pressure in the pressence of an aq. medium to thereby be liquefied to give a substance like heavy oil. The conditions of the liquefaction are controlled so that the liquefaction product contg. the substance is brought into a state with good phase separation properties.
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公开(公告)号：JPH0292910A
公开(公告)日：1990-04-03
申请号：JP24449588
申请日：1988-09-30
Applicant: AGENCY IND SCIENCE TECHN
Inventor： HINO SEIICHI , SATO SHOICHI , KOURA KOJI , SUZUKI OSAMU
IPC: C08L79/08 , C08F22/36 , C08F212/00 , C08F212/34 , C08F222/40 , C08F290/00 , C08F299/00
Abstract: PURPOSE:To obtain the title composition having excellent storage stability, molding and processing properties, undergoing self curing by heating to provide a polyimide resin having excellent heat resistance, containing a specific polymaleimide, a specific polynadiimide and an alkenylphenyl. CONSTITUTION:The aimed composition consisting essentially of (A) a polymaleimide obtained by reacting an aromatic amine (e.g., 4,4'- diaminodiphenylmethane) with maleic acid (derivative), (B) a polynadiimide obtained by reacting an aromatic polyamine with nadic acid (derivative) and (C) an alkenylphenyl {preferably dialkenylphenol shown by the formula [R1 is -CH2-, -C(CH3)2-. -SO2-, -SO-, -S-, -O-, -CH(C6H5)- or -C(CH3)2-(C6H5)-C(CH3)n-; n is 0 or 1], etc.}.
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Patent Agency Ranking
公开(公告)号：JPS63112536A
公开(公告)日：1988-05-17
申请号：JP25949586
申请日：1986-10-30
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SAKO TAKESHI , YOKOCHI TOSHIHIRO , SATO SHINJI , SUZUKI OSAMU , SHIRATA TOSHIKATSU , SUGATA TAKESHI , NAKAZAWA NOBUAKI
IPC: C07C57/12 , B01D15/08 , C07C51/00 , C07C51/47 , C07C67/00 , C07C67/56 , C07C69/58 , C11C1/08 , G01N30/02
Abstract: PURPOSE:To concentrate and purify gamma-linolenic acid, by subjecting a fatty acid mixture from a natural fat or oil or fatty acid lower alkyl ester mixture to supercritical fluid chromatography. CONSTITUTION:A fatty acid mixture obtained by hydrolyzing a natural fat or oil containing gamma-linolenic acid or fatty acid lower alkyl ester prepared by ester interchange with a lower alcohol is directly fractionated or subjected to urea addition treatment and fractionated by chromatography using a supercritical fluid, e.g. carbon dioxide, flon, etc., in a supercritical state, as a mobile phase to collect a gamma-linolenic acid fraction and carry out concentrating and purifying of the gamma-linolenic acid. The mobile phase is inexpensive and nontoxic without requiring vacuum distillation in the final step and deterioration of yield by thermal denaturation of separation products. A short time is sufficient for the treatment.
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公开(公告)号：JPS6225989A
公开(公告)日：1987-02-03
申请号：JP16530385
申请日：1985-07-26
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI OSAMU , YOKOCHI TOSHIHIRO
Abstract: PURPOSE:To make it possible to collect efficiently gamma-linolenic acid, by separating phosphatidylcholine having high content of gamma-linolenic acid from lipid collected from a specific mold and concentrating the phosphatidylcholine. CONSTITUTION:A strain such as Mortierella isabellina, Mortierella vinacea Mortierella ramaniana, Mortierella ramaniana var. anglispora, or Mortierella nana, belonging to the genus Mortierella is cultivated in a medium containing a highly concentrated carbohydrate as a carbon source, a mold with high lipid content is obtained and gamma-linolenic acid is produced from lipid collected from the mold. In producing gamma-linoleic acid, phosphatidylcholine having high content of gamma-linolenic acid is separated from the lipid, concentrated and gamma-linolenic acid is obtained. To separate the phosphatidylcholine, the lipid collected from the mold is subjected to alcohol extraction at the first step of multi-stage extraction.
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公开(公告)号：JP2000236880A
公开(公告)日：2000-09-05
申请号：JP4153899
申请日：1999-02-19
Applicant: AGENCY IND SCIENCE TECHN
Inventor： IMAMURA TORU , ASADA SHINKO , SUZUKI OSAMU , OKA SHUICHI , YONEDA ATSUKO
Abstract: PROBLEM TO BE SOLVED: To obtain a cDNA library of mutants having introduced amino acid(s) at an arbitrary site in a protein by incorporating cDNA coding for a protein into a cyclic plasmid, cleaving the obtained plasmid at an arbitrary site, followed by introducing DNA. SOLUTION: A library of cDNA is obtained which codes for a protein mutant having an introduced amino acid or peptide at an arbitrary site in its primary structure of a protein and allows selection of a desired protein mutant by incorporating cDNA coding for a protein into a cyclic plasmid, cleaving the obtained cyclic plasmid at an arbitrary site in its primary structure, inserting DNA coding for an amino acid or peptide into the cleaved site of the plasmid, wherein a nucleotide is added to 5'- and/or 3'-end(s) of DNA coding for the amino acid or peptide so as to be able to obtain a clone in which the frame of the amino acid or peptide matches with the frame of the protein into which it is introduced, and allows selecting a desired protein mutant.
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公开(公告)号：JPH04120097A
公开(公告)日：1992-04-21
申请号：JP23804090
申请日：1990-09-07
Applicant: AGENCY IND SCIENCE TECHN , MAEKAWA SEISAKUSHO KK , TAISHO PHARMA CO LTD
Inventor： MITSUI YOJI , SUZUKI OSAMU , ITOU TAKEHIRO , HARA HIROSHI
IPC: A61K38/00 , A61P1/16 , C07K1/22 , C07K14/435
Abstract: NEW MATERIAL:A hepatic cell growth factor consisting of a substance having the following physiochemical properties and physiological activity. The substance has a mol.wt. of approximately 18,000 by a SDS-polyacrylic amide gel electrophoresis, is adsorbed on heparin sepharose and eluted in a NaCl concentration of 1.9-2,0 M and has a hepatic cell growth activity. USE:A remedy for hepatic diseases such as acute hepatitis, fulminant hepatitis, chronic hepatitis and cirrhosis. PREPARATION:For example, a spleen is cut off from a cattle, ground in a buffer solution and centrifuged. The supernatant is dialyzed in a 10mM phosphoric acid buffer solution and subjected to an ion exchange column chromatography. The non-adsorbed fractions are treated with an immobilized heparin column and adsorbed substances are eluted. An active fraction is applied to a hydroxy apatite column, and adsorbed substances are eluted. The eluted substances are treated with a heparin-immobilized column and the adsorbed substance is eluted to provide the hepatic cell growth factor.
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公开(公告)号：JPS6398392A
公开(公告)日：1988-04-28
申请号：JP24319686
申请日：1986-10-15
Applicant: AGENCY IND SCIENCE TECHN , MEIJI SEIKA KAISHA
Inventor： NAKAHARA HARUROU , YOKOCHI TOSHIHIRO , KAMISAKA YASUSHI , SUZUKI OSAMU , HIRUTA OSAMU
Abstract: PURPOSE:To exclusively produce the titled substance in high conversion, by treating gamma-linolenic acid with soybean lipoxygenase in a system of an organic solvent and an aqueous solution in the presence of an anionic surfactant. CONSTITUTION:gamma-Linolenic acid is dissolved in a binary phase system composed of an organic solvent (e.g., hexane, heptane, etc.) and an aqueous solution. The aqueous solution is a boric acid buffer solution of 6.5pH. gamma-Linolenic acid is treated with soybean lipoxygenase in the above binary phase system in the presence of an anionic surfactant such as sodium polyoxyethylene alkyl ether acetate, sarcosinate L-N, etc., to convert the gamma-linolenic acid to 9-hydroperoxy-gamma- linolenic acid. The objective product is recovered by adding hydrochloric acid to the reaction mixture, extracting the oil-soluble fraction with ethyl acetate, subjecting the extract to dehydrochlorination and dehydration and developing by a reversed phase thin-layer chromatography.
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