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    PYRIDAZINIUM COMPOUNDS AND A PROCESS FOR THEIR PRODUCTION
    23.
    发明专利
    PYRIDAZINIUM COMPOUNDS AND A PROCESS FOR THEIR PRODUCTION 未知

    公开(公告)号：CA1042436A

    公开(公告)日：1978-11-14

    申请号：CA272966

    申请日：1977-03-02

    Applicant: BASF AG

    Inventor： REICHENEDER FRANZ ,  KROPP RUDOLF ,  AMANN AUGUST ,  GIERTZ HUBERT

    IPC: C07D237/10 ,  C07D237/20

    Abstract: The present invention relates to new pyridazinium compounds of the general formula (I): (I) where R1 is hydrogen, R2 denotes -NH2, R3 is hydrogen, R4 denotes the radical -SR6, R6 being an alkyl of 1 to 12 carbon atoms, R5 is phenyl and Y.THETA. is an anion of a strong inorganic or organic acid; and their production. Particularly, the above compounds may be used for their circulatory and neuropharmacological effects as well as their analgesic and antiinflammatory effects on animals.

    ONS
    24.
    发明专利
    ONS 未知

    公开(公告)号：AU496840B2

    公开(公告)日：1978-11-02

    申请号：AU7800875

    申请日：1975-02-07

    Applicant: BASF AG

    Inventor： AMANN AUGUST ,  KOENIG HORST ,  THIEME PETER ,  GIERTZ HUBERT ,  KRETZSCHMAR ROLF

    IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125 ,  C07D91/62 ,  A61K27/00 ,  C07C153/07 ,  C07C161/00

    Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

    N-substituted tris-chloromethyl acetamides
    27.
    发明专利
    N-substituted tris-chloromethyl acetamides 未知

    公开(公告)号：GB964396A

    公开(公告)日：1964-07-22

    申请号：GB3811162

    申请日：1962-10-09

    Applicant: BASF AG

    Inventor： AMANN AUGUST ,  JENTZSCH WOLFGANG ,  NEUBAUER GERALD

    IPC: C07C233/00

    Abstract: The invention comprises compounds of general formula: wherein R1 is an alkyl or cycloalkyl radical having 1 to 6 carbon atoms and R2 is either hydrogen or a bivalent radical linked to R1 to form together with the nitrogen atom a heterocyclic ring with 3 to 7 atoms in the ring; and their preparation by reaction of tris-chloromethylacetic acid or one of its functional derivatives with an amine HNR1R2. Pharmaceutical preparations of the above compounds, which have sedative and hypnotic properties, may be administered by oral, rectal and parenteral means. Solutions for oral and intraperitoneal administration are described.

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