公开(公告)号：CZ376597A3

公开(公告)日：1998-06-17

申请号：CZ376597

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS DR ,  EMLING FRANZ DR ,  ROMERDAHL CYNTHIA A DR

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：ES2052513T3

公开(公告)日：1994-07-16

申请号：ES87108847

申请日：1987-06-20

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS DR ,  MOELLER ACHIM DR ,  KOERWER WOLFGANG DR ,  DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  A61K37/02 ,  C07K15/00

公开(公告)号：DE4120916A1

公开(公告)日：1993-01-07

申请号：DE4120916

申请日：1991-06-25

Applicant: BASF AG

Inventor： BOCKSTIEGEL BERNHARD DR ,  EMLING FRANZ DR ,  JESSEL BARBARA DR ,  LECHTKEN PETER DR ,  HOERCHER ULRICH DR

IPC: C07C219/08 ,  C07C233/38

Abstract: Described are compounds of the formula: R -X-Y-NR R , plus their salts with physiologically tolerable acids and their C1-2-trialkylammonium salts. These compounds are suitable for use in the treatment of illnesses.

公开(公告)号：DE3936777A1

公开(公告)日：1991-05-08

申请号：DE3936777

申请日：1989-11-04

Applicant: BASF AG

Inventor： HILLEN HEINZ DR ,  SUBKOWSKI THOMAS DR ,  DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KLUGE MICHAEL

IPC: A61K38/00 ,  C07K1/107 ,  C07K14/525

Abstract: Described are cross-linked tumour necrosis factors suitable for use in the treatment of illnesses.

公开(公告)号：DE3925183A1

公开(公告)日：1991-02-07

申请号：DE3925183

申请日：1989-07-29

Applicant: BASF AG

Inventor： DOERPER THOMAS DR ,  HILLEN HEINZ DR ,  EMLING FRANZ DR ,  DAUM LOTHAR DR ,  MOELLER ACHIM DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07K14/47 ,  C07K14/52 ,  C07K14/525 ,  C07K19/00 ,  C12N1/21 ,  C12N5/24 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: The invention relates to derivatives of the tumour necrosis factor (TNF) produced by joining partial sequences of the heavy leukokinine chain to the terminal amino of the mature human TNF. These proteins are suitable for use in drugs. A process for obtaining them is also described.

公开(公告)号：DE3823804A1

公开(公告)日：1990-01-18

申请号：DE3823804

申请日：1988-07-14

Applicant: BASF AG

Inventor： MOELLER ACHIM DR ,  EMLING FRANZ DR ,  KURFUERST MANFRED DR ,  MEYER THOMAS DR

IPC: C12P21/06 ,  A61K39/395 ,  A61P7/00 ,  A61P9/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07K1/22 ,  C07K16/00 ,  C07K16/24 ,  C12P21/08

公开(公告)号：DE3635931A1

公开(公告)日：1988-04-28

申请号：DE3635931

申请日：1986-10-22

Applicant: BASF AG

Inventor： DAUM LOTHAR DR ,  EMLING FRANZ DR ,  KEILHAUER GERHARD DR ,  SEITZ WERNER DR

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00 ,  A61K45/05