公开(公告)号：CA1229597A

公开(公告)日：1987-11-24

申请号：CA445508

申请日：1984-01-18

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS D ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  C07D237/00

Abstract: This invention relates to the preparation of novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula (I) where the substituents on the phenylene radical are meta or para to one another, A and B are each hydrogen or together form a bond, R1 and R2 are each hydrogen or C1-C3-alkyl, or, where A and B are hydrogen, together form a C1-C4-alkylene radical, R3 is straight-chain C1-C4 alkylene which can be substituted by 1 or 2 C1-C5-alkyl groups, and R4 is a) pyrrol-1-yl, imidazol-1-yl, pyrazol-1-yl of 1,2,4triazol-1-yl, or b) a group of the formula II (II) c) a group of the formula III (III) d) a group of the formula IV -NR10R11 (IV) e) a group of the formula V (V) f) a group of the formula VI (VI) These compounds inhibit thrombocyte aggregation and gastric secretion and have hypotensive and positively inotropic properties.

公开(公告)号：DK149890B

公开(公告)日：1986-10-20

申请号：DK320081

申请日：1981-07-17

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ ,  NEUMANN PETER ,  SEYBOLD GUENTHER ,  LENKE DIETER ,  FRIEDRICH LUDWIG

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P37/08 ,  C07D213/38 ,  C07D277/44 ,  C07D277/46 ,  C07D417/02 ,  C07D417/04 ,  C07D417/10

Abstract: Novel 2-substituted thiazol-2-yl-oxamic acid esters, processes for their preparation, and therapeutic agents which contain these compounds and are useful in the treatment of allergic disorders.

公开(公告)号：CS238636B2

公开(公告)日：1985-12-16

申请号：CS783982

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：NO152129B

公开(公告)日：1985-04-29

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75

公开(公告)号：CA1180705A

公开(公告)日：1985-01-08

申请号：CA381695

申请日：1981-07-14

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ ,  NEUMANN PETER ,  SEYBOLD GUENTHER ,  LENKE DIETER ,  FRIEDRICH LUDWIG

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P37/08 ,  C07D213/38 ,  C07D277/44 ,  C07D277/46 ,  C07D417/02 ,  C07D417/04 ,  C07D417/10 ,  C07D417/00

Abstract: Novel 2-substituted thiazol-2-yl-oxamic acid esters, processes for their preparation, and therapeutic agents which contain these compounds and are useful in the treatment of allergic disorders.

公开(公告)号：AU2366084A

公开(公告)日：1984-07-26

申请号：AU2366084

申请日：1984-01-20

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  A61K31/495

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：ZA8202416B

公开(公告)日：1983-03-30

申请号：ZA8202416

申请日：1982-04-08

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETSZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS GEORG ,  MUELLER CLAUS D

IPC: A61K31/275 ,  A61K20060101 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P37/08 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/42 ,  C07C313/00 ,  C07C323/25 ,  C07C323/62 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  A61K ,  C07C

公开(公告)号：FI63403B

公开(公告)日：1983-02-28

申请号：FI781872

申请日：1978-06-12

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

公开(公告)号：ZA8104902B

公开(公告)日：1982-08-25

申请号：ZA8104902

申请日：1981-07-17

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ ,  NEUMANN PETER ,  SEYBOLD GUENTHER ,  LENKE DIETER ,  FRIEDRICH LUDWIG

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P37/08 ,  C07D277/44 ,  C07D277/46 ,  A61K ,  C07D

CPC classification number: C07D277/46

公开(公告)号：FI821252A0

公开(公告)日：1982-04-07

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MYLLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C