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    24.
    发明专利
    未知

    公开(公告)号：TR200000132T2

    公开(公告)日：2000-05-22

    申请号：TR200000132

    申请日：1998-07-07

    Applicant: BASF AG

    Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

    Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

    New peptides.
    26.
    发明专利
    New peptides. 未知

    公开(公告)号：PL178351B1

    公开(公告)日：2000-04-28

    申请号：PL30620893

    申请日：1993-05-10

    Applicant: BASF AG

    Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

    IPC: C07K5/10 ,  C07K7/06

    Abstract: 1. The peptide with the formula I where: R1> refers to a C1-7-alkyl group, C3-6-cycloalkyl group, R2> refers to an atom of hydrogen, C1-4-alkyl group, R1>-N-R2> together refer to an N-pyrrolidinyl group, A refers to valyl radical, isoleucil radical, 2-tert-butyl-glycil radical or 2-ethyl-glycil radical, B refers to N-methyl- or N-ethyl-valyl radical, norvalyl, leucil, isoleucil, 2-tert-butyl-glycol, 3-tert-butyl-alanyl radical, D and E refer to a radical selected independently from the group of radicals: prolyl, homo-prolyl, hydroxy-prolyl or thiazolidinyl-4-carbonyl; F and G refer to a radical selected independently from the group of radicals: valyl, 2-tert-butyl-glycil, isoleucil, leucil, 3-cyclohexyl-alanyl, phenyl-alanyl, N-methyl-phenyl-alanyl, tetra-hydro-iso-quinolyl-2-carbonyl, 1-aminoindole-1-carbonyl and 3-naphthyl-alanyl, X refers to a C1-5-alkyl group, v and w are independently equal to 0 or 1, while K refers to OH group, C1-7-alkoxyl group, phenoxyl group, or an amino radical with the formula R5>-N-R6>, where: R5> refers to an atom of hydrogen, or a hydroxyl group or a C1-7-alkoxyl group or benzyloxyl group or C1-7-alkyl group or fluorine-alkyl group or C3-7-cycloalkyl group or benzyl group, which can be substituted with three substituents at most, while the substituents may refer independently to CF3, nitric group, C1-7-alkyl-sulphonyl group, C1-4-alkoxyl group, phenoxyl group, benzoxyl group, a halogen or a C1-4-alkyl group; R6> refers to an atom of hydrogen or C1-7-alkyl group C3-7-cycloalkyl group or fluorine-alkyl group or phenyl group, which can be substituted with three substituents at most, while the substituents may refer independently to a CF3 group, nitric group, C1-4-alkyl group - which can form a cyclical configuration - C1-4-alkoxyl group, phenoxyl group, benzoxyl group or C1-7-alkyl-sulphonyl group...

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