公开(公告)号：AU783707B2

公开(公告)日：2005-11-24

申请号：AU5421600

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N15/00 ,  C12N15/31

公开(公告)号：AU2003298216A1

公开(公告)日：2004-07-14

申请号：AU2003298216

申请日：2003-12-19

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  HAEFNER STEFAN ,  LIEBL WOLFGANG ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD

IPC: C12P13/04

Abstract: The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.

公开(公告)号：AU2003242537A1

公开(公告)日：2003-12-02

申请号：AU2003242537

申请日：2003-05-13

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  LEE HEUNG-SHICK

IPC: C12N15/09 ,  C07K14/34 ,  C12N15/31 ,  C12P13/08

Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.

公开(公告)号：AU2002363458A1

公开(公告)日：2003-05-19

申请号：AU2002363458

申请日：2002-10-31

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  ZELDER OSKAR

IPC: C07K14/34 ,  C12N1/21 ,  C12P13/08 ,  C12N9/02 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to their use for constructing genetically improved microorganisms and to methods for producing fine chemicals, in particular, amino acids by using these genetically modified microorganisms.

公开(公告)号：AU2002349017A1

公开(公告)日：2003-05-19

申请号：AU2002349017

申请日：2002-10-31

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HABERHAUER GREGOR

IPC: C07K14/47 ,  C12N1/21 ,  C12N15/31 ,  C12N15/77 ,  C12P13/08 ,  C07K14/34 ,  C12N9/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof in the construction of genetically improved microorganisms and to a method for producing fine chemical products, in particular amino acids, by means of said genetically improved microorganisms.

公开(公告)号：AU2002346805A1

公开(公告)日：2003-05-19

申请号：AU2002346805

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  KLOPPROGGE CORINNA ,  KROGER BURKHARD ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS

IPC: C07H21/04 ,  C07K14/34 ,  C12N1/21 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12N15/31 ,  C12P13/08 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：AU2002339420A1

公开(公告)日：2003-02-24

申请号：AU2002339420

申请日：2002-07-10

Applicant: BASF AG

Inventor： DOVAL JOSE L REVUELTA ,  KROGER BURKHARD ,  KAROS MARVIN ,  ALTHOFER HENNING

IPC: C07K14/37 ,  C07K14/47 ,  C12N1/15 ,  C12N15/30 ,  C12P25/00 ,  C12Q1/68 ,  C07K16/14 ,  C12N15/80 ,  C12N15/52 ,  C12Q1/02

Abstract: The present invention relates to novel polynucleotides from Ashbya gossypii; to oligonucleotides hybridizing therewith; to expression cassettes and vectors which comprise these polynucleotides; to microorganisms transformed therewith; to polypeptides encoded by these polynucleotides; and to the use of the novel polypeptides and polynucleotides as targets for improving stress resistance and, in particular, improving vitamin B2 production in microorganisms of the genus Ashbya.

公开(公告)号：ES2162916T3

公开(公告)日：2002-01-16

申请号：ES95914301

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：SK17892000A3

公开(公告)日：2001-09-11

申请号：SK17892000

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：AU695193B2

公开(公告)日：1998-08-06

申请号：AU2135695

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I