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    27.
    发明专利
    未知

    公开(公告)号：AT229495T

    公开(公告)日：2002-12-15

    申请号：AT00115618

    申请日：2000-07-20

    Applicant: BASF AG

    Inventor： PAUST JOACHIM DR ,  ERNST HANSGEORG DR ,  KACZMAREK REINHARD DR ,  JAEDICKE HAGEN DR

    IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83

    Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).

    28.
    发明专利
    未知

    公开(公告)号：DE19723480A1

    公开(公告)日：1998-12-10

    申请号：DE19723480

    申请日：1997-06-04

    Applicant: BASF AG

    Inventor： PAUST JOACHIM DR ,  KRIEGL WOLFGANG

    IPC: C07C403/24 ,  C07D493/08 ,  C07F9/50 ,  C07F9/54

    Abstract: Preparation of (3R,3'R)-zeaxanthin (I) comprises: (i) reacting (4R)-4-hydroxy-2,2,6-trimethyl-cyclohexanone (II) with dichloromethyl lithium in an inert solvent at -120 to -40 degrees C and warming the reaction mixture to 20-60 degrees C; (ii) reacting the obtained (4R,6R)-1-formyl-2,2,6-trimethyl-7-oxa-bicyclo (2.2.1) heptane of formula (IV) (in isolated form or directly in the reaction mixture) with acetone or a dialkyl (2-oxo-propyl)-phosphonate; (iii) converting the obtained (4R,6R)-1-(3-oxo-but-1-en-1-yl)-2,2,6-trimethyl-7-oxa-bicyclo (2.2.1) heptane of formula (V) into (4R,6R)-1-(3-hydroxy-3-methylpenta-1,4-dienyl)-2,2,6-trimethyl-7-oxa-b icyclo (2.2.1) heptane (VI) by conventional vinylation (or ethynylation followed by partial hydrogenation); (iv) reacting (VI) with a triaryl phosphine (preferably PPh3) and a strong acid to give a mixture of a C15 triaryl phosphonium salt of formula (III) and the isomer of formula (III'); and (v) subjecting 2 moles of the mixture to a double Wittig olefin synthesis reaction with 2,7-dimethyl-octa-2,4,6-triene-1,8-dial (VIII) to give (I). Ar = aryl (preferably optionally substituted phenyl); and X = 1 equivalent of an anion of a strong acid (preferably Cl, Br or HSO4). The preparation of (I) by step (v) is claimed per se. Also claimed are (IV) and (V) and (III') in mixtures with (III).

    30.
    发明专利
    未知

    公开(公告)号：ES2101906T3

    公开(公告)日：1997-07-16

    申请号：ES93112314

    申请日：1993-07-31

    Applicant: BASF AG

    Inventor： KAISER KLAUS DR ,  BALKENHOHL FRIEDHELM DR ,  PAUST JOACHIM DR

    IPC: C07F9/655

    Abstract: Process for obtaining the calcium salt of ascorbyl 2-monophosphate from aqueous/alkaline reaction mixtures as they are obtained when ascorbic acid is reacted with a molar excess of phosphorus oxychloride in the presence of a tertiary amine while maintaining a pH of 12 to 13 during the reaction by means of an aqueous alkali metal solution, which process is characterised in that a) starting from a reaction mixture which has been obtained by reacting ascorbic acid with phosphorus oxychloride in the presence of pyridine while maintaining a pH of 12 to 13 by means of an aqueous potassium hydroxide solution, b) the phosphoric acid ions formed during this reaction are precipitated by means of magnesium chloride in amounts of approximately 1 mol per mol of phosphoric acid ions as potassium magnesium phosphate, c) the potassium magnesium phosphate is separated off, d) the pyridine together with some of the water is removed from the remaining aqueous solution by distillation, e) the resulting aqueous solution is reacted with calcium chloride and f) the calcium salt of ascorbyl 2-monophosphate, which crystallises out during this process in the form of the calcium salt, is isolated, or in that, after process step a), the pyridine/water mixture is first removed as described in process step d) and process steps (b), (c), (e) and (f) are subsequently carried out.

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