公开(公告)号：AU2014206958A1

公开(公告)日：2015-08-06

申请号：AU2014206958

申请日：2014-01-15

Applicant: BASF SE

Inventor： BONNEKESSEL MELANIE ,  REICHERT WOLFGANG ,  HOOCK RALF ,  KAEDING THOMAS ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  EHRESMANN MANFRED ,  SCHRODER HARTWIG

IPC: C07D493/04 ,  A01N43/90

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor;and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).

公开(公告)号：CA2898115A1

公开(公告)日：2014-07-24

申请号：CA2898115

申请日：2014-01-15

Applicant: BASF SE

Inventor： BONNEKESSEL MELANIE ,  REICHERT WOLFGANG ,  HOOCK RALF ,  KAEDING THOMAS ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  EHRESMANN MANFRED ,  SCHRODER HARTWIG

IPC: C07D493/04 ,  A01N43/90

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor;and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).