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    MICROPLATES WITH ULTRA-THIN WALLS BY TWO-STAGE FORMING
    21.
    发明专利
    MICROPLATES WITH ULTRA-THIN WALLS BY TWO-STAGE FORMING 未知

    公开(公告)号：CA2732433A1

    公开(公告)日：2010-02-04

    申请号：CA2732433

    申请日：2009-07-31

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y ,  DU HUI

    IPC: B01L3/00

    Abstract: A multi-well plate with wells having ultra-thin walls and yet with sufficient structural rigidity to allow reliable use of the plate in automated instrumentation is formed by first forming a plate blank by injection molding, the blank being of a thickness that provides the desired rigidity, and then subjecting the blank to vacuum forming to stretch designated areas in the blank to form wells or to extend wells already formed, the stretching resulting in a reduction in thickness of the molded resin at the walls of the wells only.

    MOVING COIL ACTUATOR WITH EXPANDABLE RANGE OF MOTION
    22.
    发明专利
    MOVING COIL ACTUATOR WITH EXPANDABLE RANGE OF MOTION 未知

    公开(公告)号：CA2630431A1

    公开(公告)日：2007-06-07

    申请号：CA2630431

    申请日：2006-09-29

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y

    IPC: G05B1/06

    Abstract: A moving coil actuator contains a magnet assembly that is movable to shift the range of motion of the coil. The magnet assembly moves between two or more positions along a path of travel that is parallel to the path of travel of the reciprocating motion of the coil. With this feature, the width of an area scanned by a scanning head affixed to the coil can be increased by multiples allowing a simple moving coil actuator to be used for any scanning width.

    Electrophoresis Slab Gel Enclosure for Gradient Gels
    24.
    发明专利
    Electrophoresis Slab Gel Enclosure for Gradient Gels 未知

    公开(公告)号：CA2148539A1

    公开(公告)日：1995-11-27

    申请号：CA2148539

    申请日：1995-05-03

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y

    IPC: C25B9/00 ,  G01N27/447 ,  C12Q1/68 ,  C07K1/26 ,  G01N27/26 ,  G01N33/68 ,  G01N33/561

    Abstract: Gradient gels are formed in a slab gel enclosure by introducing gel solution through a channel in one of the two or more spacers which set the thickness of the gel. The channel opens into the gel space through an aperture in the inner longitudinal edge of the spacer at approximately mid-length along the edge, and filling of the gel space with the solution is performed with the enclosure rotated onto its side. In certain embodiments of the invention, the opposing spacer contains an aperture as well, plus a channel leading from the aperture to the exterior of the enclosure, for venting of air from the gel space as the space is being filled with the gel-forming liquid.

    MASKING TO PREVENT OVEREXPOSURE AND LIGHT SPILLAGE IN MICROARRAY SCANNING
    26.
    发明申请
    MASKING TO PREVENT OVEREXPOSURE AND LIGHT SPILLAGE IN MICROARRAY SCANNING 审中-公开
    阻止在微波扫描中防止过度曝光和光泄漏

    公开(公告)号：WO2007070277A3

    公开(公告)日：2009-04-23

    申请号：PCT/US2006046286

    申请日：2006-12-04

    Applicant: BIO RAD LABORATORIES ,  CHU DANIEL Y

    Inventor： CHU DANIEL Y

    IPC: H04N1/04 ,  G01J1/58 ,  G01N21/63 ,  G02B26/10

    CPC classification number: G01N21/253 ,  G01N2201/0446 ,  G01N2201/1042

    Abstract: Scanning of a microarray is performed through a mask that exposes a plurality, but not all, of the sites of the microarray, and either the mask is movable relative to the microarray or the microarray is movable relative to the mask, or both. The mask is useful as a means of restricting the illumination of sites on the microarray to those that can be illuminated while the scan head is traveling at a steady, target velocity, blocking the passage of light between the scan head and the microarray at those points in the scan head trajectory where the scan head is either accelerating or decelerating. The mask is also useful for reducing background noise in the microarray image by preventing light spillage to sites adjacent to those being scanned.

    Abstract translation: 微阵列的扫描通过暴露微阵列的多个但不是全部的掩模进行，并且掩模可以相对于微阵列移动，或者微阵列相对于掩模或两者均可移动。 该掩模可用作将扫描头以稳定的目标速度行进的情况下将微阵列上的部位的照明限制于可被照亮的装置，阻止在那些点处扫描头和微阵列之间的光通过 在扫描头轨迹中扫描头正在加速或减速。 该掩模也可用于通过防止光泄漏到与扫描的那些相邻的位置来减少微阵列图像中的背景噪声。

    PLANAR REGISTRATION OF MULTI-WELL PLATE FROM WELL SIDE
    27.
    发明申请
    PLANAR REGISTRATION OF MULTI-WELL PLATE FROM WELL SIDE 审中-公开
    平面从多个井的多层登记

    公开(公告)号：WO2007087183A2

    公开(公告)日：2007-08-02

    申请号：PCT/US2007000961

    申请日：2007-01-12

    Applicant: BIO RAD LABORATORIES ,  CHU DANIEL Y

    Inventor： CHU DANIEL Y

    IPC: E21B23/00

    CPC classification number: B01L9/50 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/0099 ,  G01N35/028 ,  G01N2035/042 ,  G01N2035/0493

    Abstract: A multi-well plate such as a microtiter plate is secured from its well side in a manner that corrects or compensates for any deviations of the plate base from a planar configuration. This is achieved by an apparatus that includes an array of posts with exposed tips that define a plane, a plurality of movable collets that, when appropriately actuated, seize the walls of selected wells, and a biasing means to urge the collets in a direction that forces the wells of the microtiter plate against the exposed tips of the posts.

    Abstract translation: 诸如微量滴定板的多孔板从孔侧以固定或校正板基与平面构型的任何偏差的方式固定。 这通过一种装置实现，该装置包括具有限定平面的暴露尖端的柱阵列，当适当地致动时抓住选定孔的壁的多个可动夹头，以及偏压装置，以沿着 迫使微量滴定板的孔抵靠柱的露出尖端。

    SAMPLE PLATE SUPPORT OF ADJUSTABLE ANGULAR ORIENTATION
    29.
    发明专利
    SAMPLE PLATE SUPPORT OF ADJUSTABLE ANGULAR ORIENTATION 未知

    公开(公告)号：CA2642495C

    公开(公告)日：2011-05-24

    申请号：CA2642495

    申请日：2007-01-31

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y ,  PATT PAUL J ,  CEREMONY JEFFRY M

    IPC: B01L9/00 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12

    Abstract: A platform that supports a sample plate such as a microtiter plate, a multi-well plate of any size, or a glass slide with sample spots distributed over its surface, and presents the plate for assay detection by a movable scanning head that has a field depth on the millimeter scale is leveled or otherwise adjusted in a planar orientation by an apparatus that includes a rocker plate, position sensors, and motorized risers arranged on the apparatus to provide the rocker plate with tilting capability along either or both of two orthogonal axes.

    COMPACT AUTOMATED CELL COUNTER
    30.
    发明专利
    COMPACT AUTOMATED CELL COUNTER 未知

    公开(公告)号：CA2772376A1

    公开(公告)日：2011-03-03

    申请号：CA2772376

    申请日：2010-08-30

    Applicant: BIO RAD LABORATORIES

    Inventor： MCCOLLUM TOM ,  PATT PAUL ,  SHEN FRANK ,  CHU DANIEL Y ,  FLORY DON ,  GRIFFIN MIKE ,  HENG XIN ,  HEFNER ELI

    IPC: G06K9/00 ,  C12M1/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 µm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

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