公开(公告)号：ES2193123T3

公开(公告)日：2003-11-01

申请号：ES01119090

申请日：2001-08-08

Applicant: HOFFMANN LA ROCHE

Inventor： GAA OTTO ,  ALBRECHT GERTRUD ,  LOCH-LEROUX DIETER

IPC: G01N31/22 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66 ,  G01N33/96

Abstract: Test strips to control the usefulness of analysis (1), and the like, comprises initially, a reference value measurement takes a standard reference value at a reference control agent (4) as a standardized reference value for the control parameter. To control the usefulness of analysis test strips, and the like, the control parameter of the new test strip is determined as a control value to give a quotient with the first standard reference value as a control quotient. Any deviation between the control quotient and the first reference quotient is measured, and the test strip is rejected if the difference is outside a given tolerance range. The deviation is registered by a relative difference between the control quotient and the first reference quotient, or the actual difference. The new test strip is rejected if the control quotient is smaller than the first reference quotient by a given percentage or a given difference value. The tolerance range is specific to the actual charge of the test strip. The initial test strip and the further test strip are taken from the same package or dispenser, within a long-life packing, where they are each protected by separate wrappings. The test is made when a new package is used, when the first test strip is taken from the pack or on opening a long-life packing. The test stages are repeated if it is shown by the control measurement that test readings or the values measured by an analysis apparatus would be potentially affected. When a given deviation is noted, the control value for the second strip is taken as a new control reference value to give a new reference quotient for the control of further test strips. A new reference quotient is formed if the control quotient is greater than the reference quotient by more than a set threshold value, related to the actual charge of the test strip. One or more of the test stages can be automated. The reference control agent gives a higher measured value for the control parameter. The test strip has a test field (3) and a reference control agent for the measurement of the control reference value or control value. The control parameter is an optical measured value and especially a remission value.

公开(公告)号：CA2881067C

公开(公告)日：2018-06-26

申请号：CA2881067

申请日：2013-09-05

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  GAA OTTO ,  LORENZ ROBERT ,  RUECKERT FRANK

IPC: G01N21/84

Abstract: The invention concerns a method and a device for determining sample application on an analytical test element in a photometric reflectance measuring device (10) specifically for glucose measurements, where the following measures are proposed: providing a disposable test element (12) for application of a body fluid sample, taking a sequence of reflectance readings from the test element (12), monitoring a change of the reflectance readings with respect to a sample application condition, adjusting the sample application condition in accordance with a drift correction. A value for drift correction of the reflectance readings caused by ambient measurement conditions, specifically, humidity, temperature, or UV radiation can be considered in a predefined signal decrease or in a predefined signal threshold for adjusting the sample application condition.

公开(公告)号：HK1210263A1

公开(公告)日：2016-04-15

申请号：HK15110821

申请日：2015-11-03

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  GAA OTTO ,  LORENZ ROBERT ,  RUECKERT FRANK

IPC: G01N20060101

Abstract: Methods are provided for photometrically determining/detecting sample application to an analytical test element for use with a blood glucose measuring device, where the method includes obtaining a sequence of reflectance readings from the test element with the measuring device, including a blank value prior to sample application, and then monitoring changes of the reflectance readings from the test element with respect to a sample application condition defined by a limit for a reflectance decrease or a reflectance threshold. The methods also can include adjusting the sample application condition in accordance with a drift correction and can include determining an analyte concentration in the body fluid sample. In addition, photometric blood glucose measuring devices are provided that incorporate the methods disclosed herein.

公开(公告)号：CA2926287A1

公开(公告)日：2015-06-04

申请号：CA2926287

申请日：2014-11-27

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  BAUMANN EDGAR ,  GENTHNER-RIEGLER MARKUS ,  KALVERAM STEFAN ,  NIESPOREK CHRISTIAN ,  SCHWENKER KAI-OLIVER ,  SERR MARKUS ,  WEHOWSKI FREDERIC ,  WETTENGEL KLAUS

IPC: G01N21/84 ,  G01J3/433 ,  G01N21/27 ,  G01N21/47 ,  G01N21/78 ,  G01N33/487

Abstract: A method, an analytical device (114) and an analytical system (110) for determining a concentration of at least one analyte in a bodily fluid (112) is disclosed. The method comprising: a) applying a sample of the bodily fluid (112) to a test carrier (116); b) illuminating the test carrier (116) by at least one light source (127); c) receiving light remitted by the test carrier (116) by using at least one detector (132); d) determining the concentration of the analyte by evaluating at least one detector signal generated by the detector (132). The at least one light source (127) is modulated by using at least two modulation frequencies. The detector signal is demodulated with the at least two modulation frequencies in order to generate at least two demodulated detector signals, each demodulated detector signal corresponding to one of the modulation frequencies. The method comprises a fault detection based on a comparison of the at least two demodulated detector signals.

公开(公告)号：CA2738854C

公开(公告)日：2013-04-23

申请号：CA2738854

申请日：2009-11-12

Applicant: HOFFMANN LA ROCHE

Inventor： PORSCH ULRICH ,  STEIGER BERND ,  ALBRECHT GERTRUD ,  WITTMANN UWE

IPC: G01N33/487 ,  A61B5/00 ,  G06F19/00

Abstract: The invention relates to a hand-held device for measuring an analyte concentration in a sample of a body liquid having a display means (3) for displaying measured values; a measured-value storage for storing measured values; a measuring unit for generating mea-sured values through measurements of the analyte concen-tration in samples of a body liquid; a clock for supplying the date and hour of the day; a control unit for generating measured value datasets, each containing a measured value supplied by the measuring unit as well as the date and hour of the measurement by which the measured value was obtained, and for writing them into the measured-value storage; and operating elements (4) that can be actuated by the user to set the clock, in which case the control unit will generate a time-correction dataset indicating the amount and direction of the setting effected. It is provided accord-ing to the invention that the control unit writes time-cor-rection datasets into the measured-value storage so that a chronologically ordered sequence is generated containing time-correction datasets and measured value datasets.

公开(公告)号：CA2597295C

公开(公告)日：2011-07-26

申请号：CA2597295

申请日：2007-08-15

Applicant: HOFFMANN LA ROCHE

Inventor： STENKAMP BERND ,  SCHMELZEISEN-REDEKER GUENTER ,  SCHMID WILFRIED ,  MEINECKE DIETER ,  DICKOPF KAI ,  ALBRECHT GERTRUD ,  MENKE ANDREAS ,  KERN BERNHARD ,  SCHWOEBEL WOLFGANG ,  SCHULAT JOCHEN ,  KALVERAM STEFAN

IPC: G01N21/15 ,  G01N21/78

Abstract: The invention relates to a method for analyzing a sample on a test element (1) in an analysis system (9) having a test element receptacle (13) and an analysis unit (10), comprising monitoring whether an analysis region (2) of the test element (1) is positioned in the test element receptacle (13) in an analysis position relative to the analysis unit (10), the monitoring comprising the steps of .cndot. irradiation of the analysis region (2) with light from at least one light source (11, 17), .cndot. detection of light scattered or reflected at the analysis region (2) by a detector (12) for obtaining detection signals, and .cndot. evaluation of the detection signals by an evaluation unit. In this case, delimitation of a light-transmissive region (14) arranged between the test element (1) and the detector (12) is effected by a delimiting element (15) having a light-opaque region (16), the delimiting element (15) being positioned relative to the light source (11, 17) and the detector (12) in such a way that light scattered or reflected at an analysis region (22) of a test element (1) that is arranged in the test element receptacle (13) in an incorrect position in the Z direction essentially impinges on the light-opaque region (16) and does not reach the detector (12), and by comparison of the detection signals with at least one predetermined limit value for identifying an incorrect position in the Z direction in the case where the limit value is undershot.

公开(公告)号：AT480772T

公开(公告)日：2010-09-15

申请号：AT06124975

申请日：2006-11-29

Applicant: HOFFMANN LA ROCHE

Inventor： WERNER KARL ,  ALBRECHT GERTRUD

IPC: G01N33/487 ,  A61B5/00

Abstract: The method involves arranging an acoustic signal generator in an analysis system and performing analysis of a liquid sample by test units. The acoustic signal generator is controlled by a control unit of the analysis system so that the signal generator outputs an acoustic test signal in order to test functional efficiency of the signal generator. The test signal is output at starting of initial operation of the analysis system by the acoustic signal generator, where the generator acoustically codes information that is represented as number with digits. An independent claim is also included for an analysis system for analysis of a fluid sample by test units.

公开(公告)号：CA2738854A1

公开(公告)日：2010-06-10

申请号：CA2738854

申请日：2009-11-12

Applicant: HOFFMANN LA ROCHE

Inventor： PORSCH ULRICH ,  STEIGER BERND ,  ALBRECHT GERTRUD ,  WITTMANN UWE

IPC: G01N33/487 ,  A61B5/00 ,  G06F19/00

Abstract: The invention relates to a hand-held device for measuring an analyte concentration in a sample of a body liquid having a display means (3) for displaying measured values; a measured-value storage for storing measured values; a measuring unit for generating mea-sured values through measurements of the analyte concen-tration in samples of a body liquid; a clock for supplying the date and hour of the day; a control unit for generating measured value datasets, each containing a measured value supplied by the measuring unit as well as the date and hour of the measurement by which the measured value was obtained, and for writing them into the measured-value storage; and operating elements (4) that can be actuated by the user to set the clock, in which case the control unit will generate a time-correction dataset indicating the amount and direction of the setting effected. It is provided accord-ing to the invention that the control unit writes time-cor-rection datasets into the measured-value storage so that a chronologically ordered sequence is generated containing time-correction datasets and measured value datasets.

公开(公告)号：ES2326496T3

公开(公告)日：2009-10-13

申请号：ES07010017

申请日：2007-05-19

Applicant: HOFFMANN LA ROCHE

Inventor： SCHULAT JOCHEN ,  ALBRECHT GERTRUD ,  KERN BERNHARD

IPC: G01N33/487

Abstract: Aparato analizador portátil (1) para analizar una muestra, en particular un líquido biológico respecto a un componente médicamente significativo, comprendiendo un dispositivo indicador (3), una carcasa (4), una abertura de carga (5) para recibir un cargador recambiable (6), especialmente un cargador de tambor que puede contener el material analítico de consumo (10), especialmente tiras reactivas, un dispositivo de extracción (16) para extraer un material analítico de consumo (10) del cargador (6) y para el traslado a una vía de transporte, un sensor analítico al que se le puede suministrar encima de la vía de transporte un material analítico de consumo (10), y una unidad de ensayo (20) que detecta un posicionamiento correcto del material analítico de consumo (10) encima de la vía de transporte, caracterizado porque la unidad de ensayo (20) comprende, tanto un componente eléctrico de conmutación (21), que explora mecánicamente el posicionamiento de un material analítico de consumo (10) encima de la vía de transporte, que adopta como mínimo una posición de conmutación que representa la presencia de un material analítico de consumo (10) y que emite una señal sensorial en función del posicionamiento del material analítico de consumo (10, como un sensor óptico (30) que explora ópticamente el posicionamiento de un material analítico de consumo (10) encima de la vía de transporte y emite una señal sensorial en función del posicionamiento del material analítico de consumo (10), y una unidad de control (40) que evalúa la señal de conmutación del componente eléctrico de conmutación (21) y la señal sensorial del sensor óptico (30) y controla el aparato analizador portátil (1) en función de la comparación de dichas señales.

公开(公告)号：CA2630719A1

公开(公告)日：2008-11-19

申请号：CA2630719

申请日：2008-05-07

Applicant: HOFFMANN LA ROCHE

Inventor： SCHULAT JOCHEN ,  KERN BERNHARD ,  ALBRECHT GERTRUD

IPC: G01N33/48 ,  G01N21/78 ,  G01N27/04 ,  G01N33/50 ,  G01N33/66

Abstract: The invention relates to a handheld analyzer (1) for testing a sample, in particular of a biological fluid, for a medically significant component. It comprises a test unit (20), which detects the correct positioning of an analytical consumable means (10) in a conveyance pathway. According to this invention, the test unit (20) has both an electric switch component which mechanically senses the positioning of the analytical consumable means (10) and an optical sensor unit which optically senses the positioning of the analytical consumable means (10) on the conveyance pathway. The handheld analyzer (1) is controlled as a function of a comparison of the signals of the electric switch component and the optical sensor unit. It is possible in this way to reduce malfunctions or operating errors associated therewith.