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公开(公告)号:MX2012014620A
公开(公告)日:2013-02-07
申请号:MX2012014620
申请日:2011-06-30
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , RIGGLES RANDALL K , JOSEPH ABNER DAVID , BEATY TERRY A
IPC: G01N33/487
Abstract: Algunas modalidades de la invención incluyen una técnica de fabricación de 2 o más para producir tiras reactivas (100) para reducir costos, reducir desperdicio e incrementar el rendimiento. También se describen otras técnicas con relación a la técnica de 2 o más, tal como fabricar simultáneamente tiras reactivas (100) arregladas en múltiples columnas. Aun otras técnicas incluyen cortar a través de los sustratos superior (110) e inferior (130) para formar una saliente de ya sea el sustrato superior (110) o inferior (130). Otras modalidades incluyen un biosensor de uso dual en el cual un usuario puede aplicar una muestra de fluido corporal a ambas tiras reactivas de forma simultánea.
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公开(公告)号:CA2530211C
公开(公告)日:2011-10-04
申请号:CA2530211
申请日:2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
Abstract: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.
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公开(公告)号:CA2786799A1
公开(公告)日:2011-08-04
申请号:CA2786799
申请日:2011-01-27
Applicant: HOFFMANN LA ROCHE
Inventor: BEATY TERRY , GROLL HENNING , BUCK HARVEY , DIEBOLD ERIC R , JOSEPH ABNER , RIGGLES RANDY
IPC: G01N33/487 , C12Q1/00 , G01N27/30
Abstract: The present invention relates to a biosensor. The biosensor includes a support substrate, electrodes positioned on the support substrate, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a capillary channel. The electrodes include at least one working electrode defining a working electrode area in the capillary channel. The working electrode is configured to minimize variation in the working electrode area in the capillary channel due to variations in the spacer substrate placement relative to the working electrode. The working electrode comprising a main body portion and at least one connecting portion.
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公开(公告)号:CA2529579C
公开(公告)日:2011-01-25
申请号:CA2529579
申请日:2004-06-18
Applicant: HOFFMANN LA ROCHE
Inventor: BHULLAR RAGHBIR S , BUCK HARVEY B , HILL BRIAN S , WALLING PAUL DOUGLAS , BEATY TERRY A , BURKE DAVID W , DIEBOLD ERIC R
Abstract: A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
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公开(公告)号:SG11201503345VA
公开(公告)日:2015-05-28
申请号:SG11201503345V
申请日:2013-10-31
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , GERBER MARTIN T
IPC: G01N33/66 , A61B5/00 , G01N33/487 , G01N33/49
Abstract: Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
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公开(公告)号:CA2783746A1
公开(公告)日:2011-07-07
申请号:CA2783746
申请日:2010-12-23
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , BUCK HARVEY B JR , BEATY TERRY A
IPC: G01N33/49
Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.
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公开(公告)号:CA2694876A1
公开(公告)日:2005-03-24
申请号:CA2694876
申请日:2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , GHOSHAL MITALI , DENG DAVID Z , TSAI JANE SHIOW-CHUAN
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
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公开(公告)号:CA2530211A1
公开(公告)日:2005-03-24
申请号:CA2530211
申请日:2004-07-01
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , GHOSHAL MITALI , TSAI JANE SHIOW-CHUAN , DENG DAVID Z
IPC: C07F15/00 , G01N27/30 , G01N27/48 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/58
Abstract: The present invention provides novel osmium-based electrochemical species fo r the detection of wide variety of analytes using immunological techniques. Th e present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrica l signal amplification desired to analyze analytes that may be present at low concentrations.
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公开(公告)号:CA2886112C
公开(公告)日:2019-11-05
申请号:CA2886112
申请日:2013-10-31
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , GERBER MARTIN T
IPC: G01N33/66 , A61B5/00 , G01N33/487 , G01N33/49
Abstract: Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.
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公开(公告)号:CA2783746C
公开(公告)日:2017-02-07
申请号:CA2783746
申请日:2010-12-23
Applicant: HOFFMANN LA ROCHE
Inventor: DIEBOLD ERIC R , BUCK HARVEY B JR , BEATY TERRY A
IPC: G01N27/00 , G01N27/416 , G01N33/483 , G01N33/49 , G01N33/66
Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.
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