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公开(公告)号：AT345396T
公开(公告)日：2006-12-15
申请号：AT03730061
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： HORN CARINA , HOENES JOACHIM , KNAPPE WOLFGANG-REINHOLD
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.
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公开(公告)号：HK1081599A1
公开(公告)日：2006-05-19
申请号：HK06101610
申请日：2006-02-07
Applicant: HOFFMANN LA ROCHE
Inventor： HORN CARINA , HOENES JOACHIM , KNAPPE WOLFGANG-REINHOLD
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q20060101 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N20060101 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.
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公开(公告)号：CA2481787A1
公开(公告)日：2006-04-28
申请号：CA2481787
申请日：2004-10-28
Applicant: HOFFMANN LA ROCHE
Inventor： HOENES JOACHIM , SHAO ZHIXIN , KNAPPE WOLFGANG-REINHOLD , HORN CARINA , SCHMUCK RAINER
Abstract: The present invention relates to oxidoreductase apoenzyme variants whic h are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.
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公开(公告)号：CA2493918A1
公开(公告)日：2003-11-27
申请号：CA2493918
申请日：2003-05-16
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HORN CARINA , HOENES JOACHIM
IPC: C12M1/34 , C08F2/00 , C12M1/40 , C12Q1/00 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N21/78 , G01N27/327 , G01N33/543
Abstract: The invention relates to a method and reagent system for detecting an analyt e in a sample by means of an enzymatic reaction, involving the use of an enzym e- coenzyme complex as a stoichiometric reaction partner for the analyte presen t in the sample.
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公开(公告)号：CA2427029A1
公开(公告)日：2002-05-02
申请号：CA2427029
申请日：2001-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： BUNK DANIELA , THYM DETLEF , SHAO ZHIXIN , SCHMUCK RAINER , KNAPPE WOLFGANG-REINHOLD , KRATZSCH PETER
IPC: G01N33/66 , C12M1/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12N11/02 , C12N15/09 , C12N15/53 , C12P21/02 , C12Q1/32 , C12Q1/54
Abstract: The present invention relates to improved variants of soluble pyrroloquinoli ne quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specifici ty for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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Patent Agency Ranking
公开(公告)号：AU2009312781C1
公开(公告)日：2013-10-03
申请号：AU2009312781
申请日：2009-11-06
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HILLER BERND , LEHR URSULA , ZIMMER VOLKER , PETRICH WOLFGANG , BEDON-GOMEZ LUIS DAVID
Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.
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公开(公告)号：AU2009312781B2
公开(公告)日：2013-03-07
申请号：AU2009312781
申请日：2009-11-06
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HILLER BERND , LEHR URSULA , ZIMMER VOLKER , PETRICH WOLFGANG , BEDON-GOMEZ LUIS DAVID
Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.
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公开(公告)号：CA2743068A1
公开(公告)日：2010-05-14
申请号：CA2743068
申请日：2009-11-06
Applicant: HOFFMANN LA ROCHE
Inventor： KNAPPE WOLFGANG-REINHOLD , HILLER BERND , LEHR URSULA , ZIMMER VOLKER , PETRICH WOLFGANG , BEDON-GOMEZ LUIS DAVID
Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.
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公开(公告)号：AU2002215966B2
公开(公告)日：2006-05-04
申请号：AU2002215966
申请日：2001-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： BUNK DANIELA , KNAPPE WOLFGANG-REINHOLD , KRATZSCH PETER , SCHMUCK RAINER , SHAO ZHIXIN , THYM DETLEF
IPC: C12N9/04 , G01N33/66 , C12M1/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N11/02 , C12N15/09 , C12N15/53 , C12P21/02 , C12Q1/32 , C12Q1/54
Abstract: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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公开(公告)号：AU2005263591A1
公开(公告)日：2006-01-26
申请号：AU2005263591
申请日：2005-07-19
Applicant: HOFFMANN LA ROCHE
Inventor： LAGGERBAUER JESSICA , KNAPPE WOLFGANG-REINHOLD , BOENITZ-DULAT MARA , SCHMUCK RAINER , KRATZSCH PETER
Abstract: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known fromto genes encoding such variant s-GDH, to proteins of such s-GDH variants with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugars, especially of glucose in a sample.
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