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公开(公告)号：PH12021551167A1
公开(公告)日：2021-10-25
申请号：PH12021551167
申请日：2021-05-21
Applicant: HOFFMANN LA ROCHE
Inventor： KUHN BERND , GRETHER UWE , HORNSPERGER BENOIT , RICHTER HANS , KROLL CARSTEN , GROEBKE ZBINDEN KATRIN , O`HARA FIONN , ROMBACH DIDIER , LUTZ MARIUS DANIEL RINALDO
IPC: A61K31/5365 , A61P25/28 , C07D498/04 , C07D519/00
Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：AU2019322538B2
公开(公告)日：2021-09-30
申请号：AU2019322538
申请日：2019-08-12
Applicant: HOFFMANN LA ROCHE
Inventor： BELL CHARLES , BENZ JOERG , GOBBI LUCA , GRETHER UWE , GROEBKE ZBINDEN KATRIN , HORNSPERGER BENOIT , KOCER BUELENT , KROLL CARSTEN , KUHN BERND , LUTZ MARIUS DANIEL RINALDO , O`HARA FIONN , RICHTER HANS , RITTER MARTIN , ROMBACH DIDIER , KURATLI MARTIN
IPC: C07D498/04 , A61K31/5365 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P35/00
Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R
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公开(公告)号：AU2021203482A1
公开(公告)日：2021-07-01
申请号：AU2021203482
申请日：2021-05-28
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: PHENYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS Abstract (I) The invention relates to a compound of formula (I) wherein R' to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：CR20210247A
公开(公告)日：2021-06-08
申请号：CR20210247
申请日：2019-11-20
Applicant: HOFFMANN LA ROCHE
Inventor： LUTZ MARIUS DANIEL RINALDO , HORNSPERGER BENOIT , GRETHER UWE , O`HARA FIONN , KUHN BERND , RICHTER HANS , KROLL CARSTEN , ROMBACH DIDIER , GROEBKE ZBINDEN KATRIN
IPC: C07D498/04 , A61K31/5365 , A61P25/28 , C07D519/00
Abstract: La invención proporciona nuevos compuestos heterocíclicos que tienen la fórmula general (I) en donde A, B, L, X, R1, R2, R3 y R4 son, como se describen en la presente, composiciones que incluyen los compuestos, procesos para elaborar los compuestos y métodos para usar los compuestos.
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公开(公告)号：AU2016368475B2
公开(公告)日：2021-03-04
申请号：AU2016368475
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: The invention relates to a compound of formula (I) wherein R
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Patent Agency Ranking
公开(公告)号：ES2787855T3
公开(公告)日：2020-10-19
申请号：ES16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: Un compuesto de fórmula (I) **(Ver fórmula)** en la que R1 es ciclopropilo, alquilo o haloacetidinilo; R2 es ciclopropilmetoxi, alcoxi, haloalcoxi, halopiridinilo, alquilpirazolilo o halopirrolidinilo; siempre que al menos uno de R1 y R2 sea ciclopropilo o ciclopropilmetoxi; R3 es -C(O)-NH-C(R4R5)-R6, -C(O)-R7 o R8; R4 y R5 se seleccionan independientemente de hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, alquilsulfonilalquilo y alquiloxetanilo; o R4 y R5 conjuntamente con el átomo de carbono al que están unidos forman oxetanilo o dioxotietanilo; R6 es aminocarbonilo, 5-metil-1,2,4-oxadiazol-3-ilo, hidroxialquilo, tiazolilo, alcoxicarbonilo, carboxi, difluoroacetidinilcarbonilo, 5-amino-1,2,4-oxadiazol-3-ilo, alquilaminocarbonilo o aminocarbonilalquilo; R7 es (aminocarbonil)(difluoro)pirrolidinilo o (aminocarbonil)azaespiro[2.4]heptilo; y R8 es 3-alquil-1,2,4-oxadiazol-5-ilo o 5-alquil-1,2,4-oxadiazol-3-ilo; o una sal o éster farmacéuticamente aceptable del mismo.
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公开(公告)号：HUE048865T2
公开(公告)日：2020-08-28
申请号：HUE16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
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公开(公告)号：HRP20200606T1
公开(公告)日：2020-07-10
申请号：HRP20200606
申请日：2020-04-16
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
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公开(公告)号：MA43400B1
公开(公告)日：2020-05-29
申请号：MA43400
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： ROMBACH DIDIER , ROGERS-EVANS MARK , GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN
IPC: A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D231/12 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
Abstract: L'invention porte sur un composé de formule (i) dans laquelle r1 à r3 sont tels que définis dans la description et dans les revendications. Le composé de formule (i) peut être utilisé comme médicament.
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公开(公告)号：LT3386951T
公开(公告)日：2020-05-11
申请号：LT16805856
申请日：2016-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： GAVELLE OLIVIER , GRETHER UWE , NETTEKOVEN MATTHIAS , ROEVER STEPHAN , ROGERS-EVANS MARK , ROMBACH DIDIER
IPC: C07D231/12 , A61K31/4245 , A61P29/00 , C07C13/04 , C07D205/04 , C07D207/14 , C07D209/54 , C07D213/61 , C07D271/06 , C07D277/30 , C07D305/06 , C07D331/04 , C07D401/10 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12
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