公开(公告)号：DE60205408T2

公开(公告)日：2006-06-01

申请号：DE60205408

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/24 ,  G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：FR2877103A1

公开(公告)日：2006-04-28

申请号：FR0411313

申请日：2004-10-22

Applicant: MAUNA KEA TECHNOLOGIES SOC PAR ,  CENTRE NAT RECH SCIENT ,  UNIV LIMOGES

Inventor： VIELLEROBE BERTRAND ,  LACOMBE FRANCOIS ,  LOISEAU ALEXANDRE ,  LOURADOUR FREDERIC ,  LELEK MICKAEL ,  BARTHELEMY ALAIN ,  PAGNOUX DOMINIQUE

IPC: G02B23/26 ,  A61B5/00 ,  G01N21/64 ,  G02B26/08

Abstract: L'invention concerne un système d'imagerie multiphotonique fibré d'un échantillon (10) pour une utilisation en endoscopie ou en microscopie de fluorescence. Ce système comprend :- un laser pulsé femtoseconde (1, 2) pour générer un rayonnement laser multiphotonique d'excitation,- un guide d'image (8) constitué d'une pluralité de fibres optiques et permettant d'illuminer l'échantillon par un balayage point par point dans un plan subsurfacique,- des moyens de pré-compensation (4) pour compenser des effets de dispersion des impulsions d'excitation dans le guide d'image (8), ces moyens étant disposés entre le laser pulsé et le guide d'image (8),- des moyens de balayage pour diriger tour à tour le faisceau laser d'excitation dans une fibre du guide d'image, et notamment- une tête optique (9) pour focaliser le faisceau laser d'excitation sortant du guide d'image dans l'échantillon (10).

公开(公告)号：AU2005230544A1

公开(公告)日：2005-10-20

申请号：AU2005230544

申请日：2005-03-25

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： LACOMBE FRANCOIS ,  GOUALHER GEORGES LE ,  AYACHE NICHOLAS ,  PERCHANT AYMERIC

IPC: G01F1/00 ,  A61B3/12 ,  G01F1/708 ,  G01N15/14 ,  G01S15/89 ,  G02B21/00

Abstract: The invention relates to a method for measuring the speed of a particle such as a red blood cell moving inside a flow such as a flow of the blood, using a light scanning microscope. The inventive method comprises the following steps: acquisition of an image by x and y light scanning on a plane containing the object; detection on the plane (x, y) of a mark on the plane (x, y); estimation of the speed vg of the object from the gradient thus determined.

公开(公告)号：FR2865371A1

公开(公告)日：2005-07-29

申请号：FR0400581

申请日：2004-01-22

Applicant: CENTRE NAT RECH SCIENT ,  OBSERVATOIRE PARIS ,  MAUNA KEA TECHNOLOGIES

Inventor： LACOMBE FRANCOIS ,  LAFAILLE DAVID ,  GLANC MARIE ,  GENDRON ERIC ,  STEFANOVITCH DOUCHANE

IPC: A61B3/00 ,  A61B3/12 ,  A61B3/14

Abstract: The device includes an active test pattern (MAM), a movable target and a programmable trajectory. The movable target is displayed on a screen of a desktop computer, where the target is visible to an eye of a subject during a testing period. The target is constituted of set of concentric circles and an aiming mark at the center of the circles. Independent claims are also included for the following: (A) a method of sight for testing eye of a subject (B) an eye testing system using tomography in vivo.

公开(公告)号：FR2834349A1

公开(公告)日：2003-07-04

申请号：FR0116980

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：FR2834340A1

公开(公告)日：2003-07-04

申请号：FR0116981

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  BOURG HECKLY GENEVIEVE ,  VILETTE SANDRINE ,  LACOMBE FRANCOIS ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: A61B1/00 ,  A61B5/00 ,  G01N21/64 ,  G01N33/483 ,  A61B1/07

Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

公开(公告)号：CA2553743C

公开(公告)日：2014-07-22

申请号：CA2553743

申请日：2005-01-21

Applicant: CENTRE NAT RECH SCIENT ,  OBSERVATOIRE PARIS ,  MAUNA KEA TECHNOLOGIES

Inventor： LACOMBE FRANCOIS ,  LAFAILLE DAVID

IPC: G01B9/02 ,  A61B3/12

Abstract: Dispositif pour mesurer le contraste des franges dans un interféromètre de Michelson en plein champ, comprenant un prisme de Wollaston pour dévier deux polarisations perpendiculaires entrantes dans deux directions émergeantes différentes, ces moyens de déviation étant disposés au sein de l'interféromètre en substitution d'un polariseur unique. Ce dispositif est appliqué dans un interféromètre de Michelson mis en oeuvre dans un système de tomographie OCT et comprenant des moyens d'extraction du contraste interférométrique n'employant aucune technique de modulation ni des méthodes de détection synchrone.

公开(公告)号：DE602005023292D1

公开(公告)日：2010-10-14

申请号：DE602005023292

申请日：2005-03-25

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： LACOMBE FRANCOIS ,  LE GOUALHER GEORGES ,  PERCHANT AYMERIC ,  AYACHE NICHOLAS

IPC: G01S15/89 ,  A61B3/12 ,  G01F1/00 ,  G01F1/708 ,  G01N15/14 ,  G02B21/00

公开(公告)号：AU2008315834A1

公开(公告)日：2009-04-30

申请号：AU2008315834

申请日：2008-10-10

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： LAVILLONNIERE NICOLAS ,  DOUSSOUX FRANCOIS ,  BOULAROT NICOLAS ,  LACOMBE FRANCOIS ,  VIELLEROBE BERTRAND

IPC: A61B1/00 ,  A61B1/07 ,  A61B5/00 ,  G01N21/63 ,  G01N21/64 ,  G02B21/00 ,  G02B23/14 ,  G02B26/10

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

公开(公告)号：ES2306923T3

公开(公告)日：2008-11-16

申请号：ES03815393

申请日：2003-12-12

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  VIELLEROBE BERTRAND ,  GENET MAGALIE ,  LACOMBE FRANCOIS ,  SANTOS PEDRO

IPC: G02B26/08 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10

Abstract: Cabeza óptica confocal en miniatura (4) para un sistema de imagen confocal, particularmente endoscópica, al comprender dicha cabeza: - una fuente puntual (2b) que produce un haz de excitación; - medios ópticos (12, 13) adaptados particularmente para hacer converger dicho haz óptico en un punto de excitación (S) situado en un plano subsuperficial (P) con relación a la superficie de una muestra, dicho plano es perpendicular al eje óptico (A) de la cabeza óptica; y - medios de barrido de dicho punto de excitación para describir un campo de observación en dicho plano subsuperficial según dos direcciones perpendiculares de barrido, un barrido rápido en línea y un barrido lento en columna, y - medios micro sistemas mecánicos MEMs (14a-b), caracterizada porque estos medios MEMs están adaptados para desplazar en traslación según un desplazamiento escogido (Dc) por lo menos uno de los medios ópticos (12, 13) que es móvil según una dirección perpendicular a dicho eje óptico (A) de manera que se obtenga por lo menos una de dichas direcciones de barrido, y porque estos medios MEMs están adaptados par a cooperar con el medio óptico móvil (12, 13) de una manera diametralmente opuesta y alternativamente.