公开(公告)号：AU2013245503A1

公开(公告)日：2013-11-07

申请号：AU2013245503

申请日：2013-10-17

Applicant: PHARMACYCLICS INC

Inventor： LOURY DAVID ,  VERNER ERIK ,  CHEN WEI ,  HONIGBERG LEE ,  BUGGY JOSEPH

IPC: A61K31/52 ,  A61P35/00

Abstract: Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.

公开(公告)号：ZA201207075B

公开(公告)日：2013-06-26

申请号：ZA201207075

申请日：2012-09-20

Applicant: PHARMACYCLICS INC

Inventor： HONIGBERG LEE ,  PAN ZHENGYING ,  VERNER ERIK

IPC: A61K20060101 ,  A01N20060101 ,  A61P20060101

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：ZA201100893B

公开(公告)日：2013-03-27

申请号：ZA201100893

申请日：2011-02-03

Applicant: PHARMACYCLICS INC

Inventor： HONIGBERG LEE ,  PAN ZHENGYING ,  VERNER ERIK

IPC: A61K20060101 ,  A01N20060101 ,  A61P20060101

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：CR20120244A

公开(公告)日：2013-01-03

申请号：CR20120244

申请日：2012-05-11

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

Abstract: Se describen aquí compuestos inhibidores de quinasa, métodos para sintetizar tales inhibidores y métodos para utilizar tales inhibidores en el tratamiento de enfermedades. Se describen aquí adicionalmente métodos, ensayos y sistemas para determinar un inhibidor apropiado de una proteína, incluyendo una quinasa.

公开(公告)号：MX2012004258A

公开(公告)日：2012-05-29

申请号：MX2012004258

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： LOURY DAVID J ,  CHEN WEI ,  VERNER ERIK ,  LOURY DAVID J ,  MODY TARAK D ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: A61F2/24 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07C6/02 ,  C07D401/04 ,  C07D401/14 ,  C07D487/04

Abstract: Se describen aquí compuestos inhibidores de quinasa, métodos para sintetizar tales inhibidores y métodos para utilizar tales inhibidores en el tratamiento de enfermedades. Se describen aquí adicionalmente métodos, ensayos y sistemas para determinar un inhibidor apropiado de una proteína, incluyendo una quinasa.

公开(公告)号：AU2010306921A1

公开(公告)日：2012-05-10

申请号：AU2010306921

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D401/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/14 ,  C07D487/04

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：CA2776543A1

公开(公告)日：2011-04-21

申请号：CA2776543

申请日：2010-10-12

Applicant: PHARMACYCLICS INC

Inventor： CHEN WEI ,  LOURY DAVID J ,  MODY TARAK D ,  VERNER ERIK ,  SMYTH MARK STEPHEN ,  LUO WENCHEN

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P19/10 ,  C07D401/04 ,  C07D401/14

Abstract: Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

公开(公告)号：BRPI0622054A2

公开(公告)日：2010-11-09

申请号：BRPI0622054

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

IPC: A01N43/90 ,  A61K31/519

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：CA2874756A1

公开(公告)日：2008-10-09

申请号：CA2874756

申请日：2008-03-27

Applicant: PHARMACYCLICS INC

Inventor： HONIGBERG LEE ,  VERNER ERIK ,  BUGGY JOSEPH J ,  LOURY DAVID ,  CHEN WEI

IPC: C07D487/04 ,  A61K31/519 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C12N9/12 ,  C12Q1/48 ,  G01N33/53

Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.

公开(公告)号：CA2668286A1

公开(公告)日：2008-05-08

申请号：CA2668286

申请日：2007-11-05

Applicant: PHARMACYCLICS INC

Inventor： VERNER ERIK ,  LI SHYR JIANN ,  SCHEREENS HELEEN ,  PAN ZHENGYING ,  HONIGBERG LEE

IPC: C07D487/00

Abstract: Described herein are probes for Bruton's tyrosine kinase (Btk). Such prob es are used to characterize and develop Btk-selective inhibitors intended fo r therapeutic use.