公开(公告)号：AU2023203241A1

公开(公告)日：2023-06-15

申请号：AU2023203241

申请日：2023-05-23

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：MX2020014098A

公开(公告)日：2021-05-27

申请号：MX2020014098

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： GERASYUTO ALEKSEY I ,  WOLL MATTHEW G ,  CHEN GUANGMING ,  NARASIMHAN JANA ,  ZHANG NANJING ,  KARP GARY MITCHELL ,  SYDORENKO NADIYA ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  MAZZOTTI ANTHONY R ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  MOON YOUNG-CHOON ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  KASSICK ANDREW J ,  YAN WUMING

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se refiere a compuestos heterocíclicos y de heteroarilo sustituidos de Fórmula (I), formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.

公开(公告)号：SG11202012674PA

公开(公告)日：2021-01-28

申请号：SG11202012674P

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2019294482A1

公开(公告)日：2021-01-21

申请号：AU2019294482

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2019294478A1

公开(公告)日：2021-01-21

申请号：AU2019294478

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CA3104516A1

公开(公告)日：2020-01-02

申请号：CA3104516

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.