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公开(公告)号：FI3814357T3
公开(公告)日：2024-07-26
申请号：FI19736566
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC , PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：HRP20240935T1
公开(公告)日：2024-11-22
申请号：HRP20240935
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
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公开(公告)号：HUE068060T2
公开(公告)日：2024-12-28
申请号：HUE19736566
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
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公开(公告)号：AU2019294478B2
公开(公告)日：2023-03-23
申请号：AU2019294478
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：AU2022201299A1
公开(公告)日：2022-03-24
申请号：AU2022201299
申请日：2022-02-25
Applicant: PTC THERAPEUTICS INC
Inventor： WOLL MATTHEW G , AMEDZO LUKIANA , BABU SURESH , BARRAZA SCOTT J , BHATTACHARYYA ANURADHA , KARP GARY MITCHELL , MAZZOTTI ANTHONY R , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , XU ZHENRONG
IPC: C07D239/74 , C07D239/94 , C07D239/95
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. ,W1 W2 R2 W6 2~ (I) In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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Patent Agency Ranking
公开(公告)号：PE20211378A1
公开(公告)日：2021-07-27
申请号：PE2020002185
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: Esta referido a compuestos de Formula I, en donde: R1 es cicloalquilo, heterociclilo C3-10-carbonilo; R2 es fenilo, heterociclilo, heteroarilo; W1 es C-Ra, CH-Ra, N, N-Rb, O, S; W2 es C-Ra, CH-Ra, N, N-Rb; W3 es C, CH, N; W4 y W5 son C-Ra o N. entre los compuestos preferidos tenemos los siguientes: 5-(1H-pirazol-4-il)-2-[1-(2,2,6,6-tetrametilpiperidin-4-il)-1H-imidazo[4,5-b]pirazin-5-il]fenol; 5-[2,5-difluoro-4-(1H-pirazol-4-il)fenil]-1-(2,2,6,6-tetrametilpiperidin-4-il)-1H-imidazo[4,5-b]pirazina; 5-(1H-pirazol-4-il)-2-[7-(2,2,6,6-tetrametilpiperidin-4-il)-7H-imidazo[4,5-c]piridazin-3-il]fenol; entre otros. Estos compuestos se emplean para tratar o mejorar la enfermedad de Huntington.
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公开(公告)号：SG11202009212WA
公开(公告)日：2020-10-29
申请号：SG11202009212W
申请日：2019-03-26
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , BABU SURESH , BHATTACHARYYA ANURADHA , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR
IPC: C07D241/12 , C07D241/20 , C07D401/14
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：AU2023203241B2
公开(公告)日：2025-01-02
申请号：AU2023203241
申请日：2023-05-23
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：PL3814357T3
公开(公告)日：2024-09-16
申请号：PL19736566
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
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公开(公告)号：RS65727B1
公开(公告)日：2024-08-30
申请号：RSP20240779
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
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