公开(公告)号：FI3814357T3

公开(公告)日：2024-07-26

申请号：FI19736566

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC ,  PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：HRP20240935T1

公开(公告)日：2024-11-22

申请号：HRP20240935

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

公开(公告)号：AU2019294482B2

公开(公告)日：2022-09-01

申请号：AU2019294482

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2022209304A1

公开(公告)日：2022-08-25

申请号：AU2022209304

申请日：2022-07-28

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. W3 R2 R 3 X (I) (II) In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：SI3814357T1

公开(公告)日：2024-09-30

申请号：SI201930785

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/00 ,  A61K31/00 ,  A61P25/00 ,  C07D491/00 ,  C07D495/00 ,  C07D519/00

公开(公告)号：LT3814357T

公开(公告)日：2024-06-25

申请号：LTUS2019038889

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

公开(公告)号：CO2020016285A2

公开(公告)日：2021-01-18

申请号：CO2020016285

申请日：2020-12-24

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. Fórmula (i). En particular, la presente descripción se refiere a compuestos heterocíclicos y de heteroarilo sustituidos de Fórmula (I), formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.

公开(公告)号：HUE068060T2

公开(公告)日：2024-12-28

申请号：HUE19736566

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

公开(公告)号：AU2019294478B2

公开(公告)日：2023-03-23

申请号：AU2019294478

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：PE20211378A1

公开(公告)日：2021-07-27

申请号：PE2020002185

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: Esta referido a compuestos de Formula I, en donde: R1 es cicloalquilo, heterociclilo C3-10-carbonilo; R2 es fenilo, heterociclilo, heteroarilo; W1 es C-Ra, CH-Ra, N, N-Rb, O, S; W2 es C-Ra, CH-Ra, N, N-Rb; W3 es C, CH, N; W4 y W5 son C-Ra o N. entre los compuestos preferidos tenemos los siguientes: 5-(1H-pirazol-4-il)-2-[1-(2,2,6,6-tetrametilpiperidin-4-il)-1H-imidazo[4,5-b]pirazin-5-il]fenol; 5-[2,5-difluoro-4-(1H-pirazol-4-il)fenil]-1-(2,2,6,6-tetrametilpiperidin-4-il)-1H-imidazo[4,5-b]pirazina; 5-(1H-pirazol-4-il)-2-[7-(2,2,6,6-tetrametilpiperidin-4-il)-7H-imidazo[4,5-c]piridazin-3-il]fenol; entre otros. Estos compuestos se emplean para tratar o mejorar la enfermedad de Huntington.