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    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES
    23.
    发明专利
    SEQUENCE SYMMETRIC MODIFIED IGG4 BISPECIFIC ANTIBODIES 未知

    公开(公告)号：CA2865261A1

    公开(公告)日：2013-08-29

    申请号：CA2865261

    申请日：2013-02-22

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE

    IPC: C07K16/00

    Abstract: The present disclosure provides an asymmetric mixed antibody comprising two heavy chains or heavy chain fragments each comprising at least a variable region, a hinge region and a CH1 domain, wherein a first heavy chain or fragment thereof is a class IgG4 and has: a the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, and wherein the second heavy chain or fragment thereof is characterised in that part or all of the chain has a different amino acid sequence to said first heavy chain in at least the region outside the variable region (for example the constant region), formulations comprising the same, therapeutic used of both of the above, and processes for preparing the antibodies and formulation.

    IMPROVED ANTIBODIES OF THE CLASS IGG4
    25.
    发明专利
    IMPROVED ANTIBODIES OF THE CLASS IGG4 未知

    公开(公告)号：SG187677A1

    公开(公告)日：2013-03-28

    申请号：SG2013007950

    申请日：2011-08-19

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  PETERS SHIRLEY JANE ,  ADAMS RALPH ,  HEADS JAMES

    Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

    Bacterial host strain
    27.
    发明专利
    Bacterial host strain 未知

    公开(公告)号：AU2010299640A1

    公开(公告)日：2012-04-12

    申请号：AU2010299640

    申请日：2010-09-23

    Applicant: UCB PHARMA SA

    Inventor： ELLIS MARK ,  HUMPHREYS DAVID PAUL

    IPC: C12N9/50 ,  C12P21/00

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest.

    29.
    发明专利
    未知

    公开(公告)号：AT541590T

    公开(公告)日：2012-02-15

    申请号：AT04743216

    申请日：2004-07-01

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP ,  CARRINGTON BRUCE

    IPC: A61K47/48 ,  C07K16/24 ,  C07K16/28

    Abstract: The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of C L and the interchain cysteine of C H 1 have been replaced with another amino acid.

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