公开(公告)号：AU2010226400B2

公开(公告)日：2016-07-14

申请号：AU2010226400

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP GUERETTE DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

公开(公告)号：BRPI1011506A8

公开(公告)日：2016-07-05

申请号：BRPI1011506

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  KRUEGER BRIAN R ,  YAP DAHRIKA MILFRED LAO ,  GOOR FREDERICK F VAN ,  ZLOKARNIK GREGOR ,  DEMATTEI JOHN ,  TRUDEAU MARTIN ,  BOTFIELD MARTYN C ,  RYAN MICHAEL P ,  GROOTENHUIS PETER D J ,  ROEPER STEFANIE

IPC: C07D215/233

公开(公告)号：PL2408750T3

公开(公告)日：2016-02-29

申请号：PL10710749

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：DK2408750T3

公开(公告)日：2015-10-05

申请号：DK10710749

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：IN885KON2014A

公开(公告)日：2015-10-02

申请号：IN885KON2014

申请日：2014-04-23

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM R ,  LITTLER BENJAMIN JOSEPH ,  CHOUDHURY ANUSUYA ,  HARRISON CRISTIAN L ,  VELURI RAVIKANTH ,  RYAN MICHAEL P ,  JIANG LICONG ,  LUSS LUSIS EDUARD

IPC: C07D405/12 ,  C07D405/14 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof are useful as modulators of ATP Binding Cassette ('ABC') transporters or fragments thereof including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：SG193156A1

公开(公告)日：2013-09-30

申请号：SG2013057393

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent. 0 0 No available figure

公开(公告)号：CA2852991A1

公开(公告)日：2013-05-16

申请号：CA2852991

申请日：2012-11-08

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM R ,  LITTLER BENJAMIN JOSEPH ,  CHOUDHURY ANUSUYA ,  HARRISON CRISTIAN L ,  VELURI RAVIKANTH ,  RYAN MICHAEL P ,  JIANG LICONG ,  LUSS-LUSIS EDUARD

IPC: C07D405/12 ,  A61K31/405 ,  A61K31/553 ,  A61P1/00 ,  A61P3/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/00 ,  A61P35/00 ,  C07D405/14 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：ZA201106619B

公开(公告)日：2012-11-28

申请号：ZA201106619

申请日：2011-09-09

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D20060101

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 2; in the presence of a coupling agent.

公开(公告)号：SG174410A1

公开(公告)日：2011-11-28

申请号：SG2011066578

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

公开(公告)号：AU2010226400A1

公开(公告)日：2011-10-06

申请号：AU2010226400

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： JOHN DEMATTEI ,  LOOKER ADAM R ,  BOBBIANNA NEUBERT-LANGILLE ,  MARTIN TRUDEAU ,  STEFANIE ROEPER ,  RYAN MICHAEL P ,  LAO YAP DAHRIKA MILFRED ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK F VAN ,  BOTFIELD MARTYN C ,  GREGOR ZLOKARNIK

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.