公开(公告)号：EP2716305B1

公开(公告)日：2016-03-30

申请号：EP12792482.7

申请日：2012-06-04

Applicant: Korea Basic Science Institute

Inventor： SEOK, Dong Chan ,  LHO, Tai Hyeop

IPC: A61L2/22 ,  A61L2/14 ,  A61L2/12 ,  A61L2/26

CPC classification number: A61L2/14 ,  A61L2/208 ,  A61L2202/11 ,  A61L2202/24 ,  H05H1/46 ,  H05H2001/4622 ,  H05H2245/1225

Abstract: The present invention relates to an apparatus for sterilization which may be applied to a medical dry sterilizer, and more particularly, to an apparatus which injects hydrogen peroxide so as to generate plasma and OH radicals which are effective in sterilization, so as to achieve the sterilization of a treated object. According to the present invention, the apparatus for sterilization comprises: a sterilizing reactor in which sterilization is performed on a treated object; a vacuuming unit which is equipped with a vacuum pump connected to the sterilizing reactor and which vacuumizes the interior of the sterilizing reactor; a hydrogen-peroxide supply unit which supplies hydrogen peroxide in a gas state to the interior of the sterilizing reactor; and a microwave-plasma generating unit which generates plasma using microwaves. The microwave-plasma generating unit is provided with an electromagnetic-wave generating source which generates microwaves; a plasma-generating unit which interconnects the hydrogen-peroxide supply unit and the sterilizing reactor such that hydrogen peroxide is supplied to the sterilizing reactor, and which generates plasma using microwaves; and a microwave guide which delivers the microwaves generated from the electromagnetic-wave generating source to the plasma-generating unit.

公开(公告)号：EP2269046B1

公开(公告)日：2014-08-06

申请号：EP08753475.6

申请日：2008-05-14

Applicant: Korea Basic Science Institute

Inventor： YOON, Jang Hee ,  WON, Mi Sook

IPC: G01N27/30 ,  G01N33/18

CPC classification number: G01N33/1893 ,  G01N27/308 ,  G01N33/1813

公开(公告)号：EP2716305A1

公开(公告)日：2014-04-09

申请号：EP12792482.7

申请日：2012-06-04

Applicant: Korea Basic Science Institute

Inventor： SEOK, Dong Chan ,  LHO, Tai Hyeop

IPC: A61L2/22 ,  A61L2/14 ,  A61L2/12 ,  A61L2/26

CPC classification number: A61L2/14 ,  A61L2/208 ,  A61L2202/11 ,  A61L2202/24 ,  H05H1/46 ,  H05H2001/4622 ,  H05H2245/1225

Abstract: The present invention relates to an apparatus for sterilization which may be applied to a medical dry sterilizer, and more particularly, to an apparatus which injects hydrogen peroxide so as to generate plasma and OH radicals which are effective in sterilization, so as to achieve the sterilization of a treated object. According to the present invention, the apparatus for sterilization comprises: a sterilizing reactor in which sterilization is performed on a treated object; a vacuuming unit which is equipped with a vacuum pump connected to the sterilizing reactor and which vacuumizes the interior of the sterilizing reactor; a hydrogen-peroxide supply unit which supplies hydrogen peroxide in a gas state to the interior of the sterilizing reactor; and a microwave-plasma generating unit which generates plasma using microwaves. The microwave-plasma generating unit is provided with an electromagnetic-wave generating source which generates microwaves; a plasma-generating unit which interconnects the hydrogen-peroxide supply unit and the sterilizing reactor such that hydrogen peroxide is supplied to the sterilizing reactor, and which generates plasma using microwaves; and a microwave guide which delivers the microwaves generated from the electromagnetic-wave generating source to the plasma-generating unit.

Abstract translation: 本发明涉及可应用于医用干式灭菌器的灭菌装置，更具体地，涉及注射过氧化氢以产生有效灭菌的等离子体和OH自由基的装置，以实现灭菌 的处理对象。 根据本发明，灭菌装置包括：灭菌反应器，其对被处理物进行灭菌; 一个抽真空装置，它装有一个与杀菌反应器连接的真空泵，并对灭菌反应器的内部进行真空化; 过氧化氢供给单元，其将气态的过氧化氢供给到灭菌反应器的内部; 以及使用微波产生等离子体的微波等离子体生成单元。 微波等离子体产生单元设置有产生微波的电磁波发生源; 等离子体产生单元，其将过氧化氢供给单元和灭菌反应器相互连接，使得向杀菌反应器供给过氧化氢，并使用微波产生等离子体; 以及微波引导器，其将从电磁波发生源产生的微波输送到等离子体发生单元。

公开(公告)号：EP2690651A1

公开(公告)日：2014-01-29

申请号：EP11861350.4

申请日：2011-05-30

Applicant: Korea Basic Science Institute

Inventor： YOO, Suk Jae ,  KIM, Seong Bong

IPC: H01L21/20 ,  H01L33/32

CPC classification number: H01L21/0257 ,  C30B25/02 ,  C30B25/105 ,  C30B29/406 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02576 ,  H01L21/02579 ,  H01L21/0262 ,  H01L21/02631 ,  H01L21/02656 ,  H01L21/67161 ,  H01L21/67207 ,  H01L33/0066

Abstract: The present invention relates to an apparatus and method for manufacturing a semiconductor light-emitting device using a neutral particle beam. According to the present invention, since the kinetic energy of the neutral particle beam is provided as a portion of the reaction energy for causing a nitride semiconductor single crystal thin film to be formed on a substrate, and the reaction energy is not provided as heat energy by heating a substrate as in the prior art, the substrate may be treated at a relatively low temperature. Furthermore, elements such as Si, Mg, and the like, which are solid elements required for doping are sprayed onto the substrate from a source which generates solid elements for doping together with the neutral particle beam to achieve high doping efficiency at a lower temperature. According to the present invention, since the substrate is treated at a low temperature, the degradation of the substrate and thin film may be prevented, and the undesired diffusion of the doping elements may be prevented to enable the manufacture of the semiconductor light-emitting device having superior light-emitting properties in a relatively easy manner.

Abstract translation: 本发明涉及的装置和方法，用于使用中性粒子束制造半导体发光器件。 。根据本发明，由于在中性粒子束的动能作为用于使氮化物半导体单晶薄膜上的基片要形成一个反应能量的部分提供，并在反应能量不为热能提供 通过加热基底如在现有技术中，基板可在相对低的温度进行处理。 进一步，元件：如Si，Mg和类似物，它们是嵌入所需固体元件被喷涂在底材上从源哪些基因率与中性粒子束一起掺杂在较低的温度，以实现高掺杂效率的实体单元。 。根据本发明，由于基板是在低温下进行处理，在基板和薄膜的退化可以被防止，并且所述掺杂元素的不期望的扩散可以被防止，以使半导体发光装置的制造 具有相对容易的方式优越的发光特性。

公开(公告)号：EP2325864A1

公开(公告)日：2011-05-25

申请号：EP10191809.2

申请日：2010-11-19

Applicant: Korea Basic Science Institute

Inventor： Choi, Myoung Choul ,  Kim, Hyun Sik ,  Yoo, Jong Shin ,  Kim, Geon Hee ,  Chang, Ki Soo

IPC: H01J49/16

CPC classification number: H01J49/164

Abstract: A high throughput apparatus for multiple sample analysis is disclosed. The high through apparatus for multiple sample analysis may include: a laser light source; a lens array configured to focus laser irradiated by the laser light source into a plurality of focused laser beams; and a focusing unit disposed between the lens array and a sample, the focusing unit configured to focus ions produced from the sample by the plurality of focused laser beams into a plurality of ion beams. A high throughput method for multiple sample analysis may include: producing a plurality of focused laser beams by focusing laser; ionizing a sample by irradiating the plurality of focused laser beams to the sample; and producing a plurality of ion beams by focusing ions, wherein the ions are produced from the sample by the plurality of focused laser beams.

Abstract translation: 公开了一种用于多样品分析的高通量装置。 用于多次样品分析的高通量装置可以包括：激光源; 配置成将由激光光源照射的激光聚焦成多个聚焦激光束的透镜阵列; 以及设置在所述透镜阵列和样本之间的聚焦单元，所述聚焦单元被配置为将由所述多个聚焦激光束从所述样本产生的离子聚焦成多个离子束。 用于多样本分析的高通量方法可以包括：通过聚焦激光产生多个聚焦激光束; 通过将多个聚焦激光束照射到样品上来使样品电离; 并通过聚焦离子产生多个离子束，其中通过多个聚焦激光束从样品产生离子。

公开(公告)号：EP2187213A1

公开(公告)日：2010-05-19

申请号：EP09168598.2

申请日：2009-08-25

Applicant: Korea Basic Science Institute

Inventor： Lee, Zee Won ,  Kim, Soo Hyun

IPC: G01N33/542 ,  G01N33/557 ,  G01N33/58 ,  G01N33/68 ,  G01N33/50 ,  C12N15/10

CPC classification number: G01N33/5035 ,  C07K2319/01 ,  C07K2319/60 ,  G01N33/542 ,  G01N33/557 ,  G01N33/582 ,  G01N33/6845

Abstract: Disclosed is a novel method for detecting interactions of biomolecules. More particularly, the disclosed method includes (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the second construct in the cell. The present invention provides a method capable of detecting bindings and interactions occurring in a living cell in real time, and a method for screening a material that alters the binding and the interaction. The method of the present invention overcomes the disadvantages including inaccuracy and complexity of existing biomaterial interaction detection techniques. By labeling both constructs to promote accuracy, the present invention provides a novel real-time, antibody-free analysis.

Abstract translation: 公开了一种用于检测生物分子的相互作用的新方法。 更具体地，盘方法游离缺失包括：（a）制备细胞，其包含（i）第一构建体，包含诱饵的第一标记物质和易位模块; 和（ii）第二构建体，包含捕食和第二标记物质; （b）检测所述第一构建体在细胞中的分布和所述第二构建体。 本发明提供了能够检测绑定和相互作用进行实时的活细胞内发生的方法，和用于筛选的材料做了年龄的结合和相互作用的方法。 在本发明的方法而来的缺点，包括不准确的和现有的生物材料相互作用的检测技术的复杂性。 通过标记两个构建体，以促进准确度，本发明提供了一种新颖的实时，无抗体的分析。

公开(公告)号：EP1642129B1

公开(公告)日：2008-08-20

申请号：EP04709767.0

申请日：2004-02-10

Applicant: Korea Basic Science Institute

Inventor： AHN, Yeong Hee ,  YOO, Jong Shin ,  KIM, Jin Young ,  CHO, Kun

IPC: G01N33/53 ,  G01N33/48 ,  C12Q1/68

CPC classification number: G01N33/6848 ,  A61K31/155 ,  G01N33/6803 ,  G01N33/6842 ,  G01N2458/15

Abstract: Disclosed is a method of analyzing mass of the phosphoproteins or phosphopeptides and of analyzing phosphorylated positions at a phosphoprotein or phosphopeptide, comprising the steps of: 1) dephosphorylating at least one Ser and/or Thr residue of the phosphoprotein or phosphopeptide; 2) tagging the dephosphorylated amino acid residues with a tag having a R-L-G moiety wherein R is a nucleophilic functional group that selectively bind with dephosphorylated amino acid residues, G is selected from the group consisting of guanidine moiety or protected guanidine moiety such as a mono-N-protected guanidino group, a di-N,N'-protected guanidino group and an N'-protected guanidino group, and L is a linker linking the R and the G; and 3) subjecting the tagged proteins or peptides to mass spectrometry. The method is capable of precisely analyzing mass of phosphoproteins of trace amounts as well as positions of phosphoryated amino acids.

公开(公告)号：EP1951613A1

公开(公告)日：2008-08-06

申请号：EP06799352.7

申请日：2006-10-20

Applicant: Korea Basic Science Institute

Inventor： KIM, Hae Jin ,  LEE, Jin Bae

IPC: B82B3/00 ,  B82B1/00

CPC classification number: C01G45/02 ,  B82Y30/00 ,  C01P2002/72 ,  C01P2004/02 ,  C01P2004/04 ,  C01P2004/13 ,  C01P2004/16 ,  C01P2004/60 ,  C01P2006/40 ,  C01P2006/60 ,  C04B35/053 ,  C04B35/111 ,  C04B38/00 ,  C04B2111/00008 ,  C30B7/00 ,  C30B29/16 ,  C30B29/602 ,  H01M4/0404 ,  H01M4/043 ,  H01M4/505 ,  H01M4/621 ,  H01M4/625 ,  H01M10/052 ,  Y02E60/122 ,  Y02P70/54 ,  C04B38/0054

Abstract: The present invention relates to methods for manufacturing manganese oxide nanotubes/nanorods using an anodic aluminum oxide (AAO) template. In the inventive methods, the manganese oxide nanotubes/nanorods are manufactured in mild conditions using only a manganese oxide precursor and an anodic aluminum oxide template without using any solvent. The nanotubes/nanorods having uniform size can be easily obtained by adsorbing the manganese oxide precursor onto the surface of the anodic aluminum oxide template by a vacuum forming process using a vacuum filtration apparatus so as to maintain the shape of nanotubes/nanorods and drying the manganese oxide nanotubes. The manganese oxide nanotubes/nanorods made according to the inventive methods can be used as economic hydrogen reservoirs, the electrode of lithium secondary batteries, or the energy reservoirs of vehicles or other transport means.

公开(公告)号：EP1946119A1

公开(公告)日：2008-07-23

申请号：EP05808964.0

申请日：2005-09-14

Applicant: Korea Basic Science Institute

Inventor： AHN, Yeong Hee ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G01N33/68

CPC classification number: C07K14/4732

Abstract: The present invention relates to a method for analyzing modified polypeptide sequence and modified information thereof. More precisely, the invention relates to a method for identifying modified peptide in which fragment ion signals are obtained from target peptide precursor by using tandem mass spectrometry, candidate peptides and every possible peptide fragmentation patterns thereof are designed based on the mass data thereby, match scores corresponding to each fragmentation pattern of candidate peptides are given, and then by combining each matching scores derived from possible fragmentation patterns of a candidate peptide, modified target polypeptide is identified by tandem mass data based on the provided match score. The scoring method for modified polypeptide of the present invention can greatly contribute to increasing searching efficiency of modified peptides and reliability of the searching results by integrating all scored values obtained from different fragmentation patterns of a candidate peptide.

公开(公告)号：EP1799845A1

公开(公告)日：2007-06-27

申请号：EP04793448.4

申请日：2004-10-08

Applicant: Korea Basic Science Institute

Inventor： AHN, Yeong Hee ,  YOO, Jong Shin ,  LEE, Jae Yong ,  KIM, Jin Young ,  0HO, Kun

IPC: C12Q1/37

CPC classification number: G01N33/6842 ,  G01N33/6848

Abstract: The present invention relates to a method for phosphorylation site-specific labeling of phosphoproteome with a site-specific tagging reagent and analyzing of the resulting labeled one, more especially, a method for in-situ tagging of phosphorylation sites of phosphoproteins retained in polymeric gel with a nucleophilic tagging reagent. It also relates a method for generating new proteolytic cleavable sites at formerly phosphorylation sites by a proper choice of a nucleophilic tagging reagent. It also relates to a method for phosphopeptides analysis and phosphorylation site identification by in-gel digestion of the previously in-gel tagged proteins and subsequent mass analysis of the resulting peptides. The invention provides in-gel chemical tagging method for phosphoaminoacid residue of phosphoproteins retained in polymeric gel matrix. Phosphoprotein can be immobilized into gel matrix by a variety of methods such as gel electrophoresis. The immobilized phosphoproteins are retained in gel matrix during tagging reaction to phosphorylated aminoacid residue of phosphoproteins, and the resulting tagged proteins are also retained in gel matrix till following purification steps like washing of the tagging reagents are accomplished. The tagged proteins is digested by protease, and the resulting digested peptides is released from gel into solution and applied for peptide mass analysis.