公开(公告)号：AU2014203008B2

公开(公告)日：2016-03-31

申请号：AU2014203008

申请日：2014-06-03

Applicant: ACADEMIA SINICA

Inventor： CHANG TSEWEN ,  CHEN JIUN-BO ,  WU PHEIDIAS ,  HUNG ALFUR F

IPC: C07K16/28 ,  A61K38/10 ,  A61K39/395 ,  A61P37/00

Abstract: ANTI-CEmX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES Abstract The invention pertains to the generation and utility of antibodies that can bind effectively to CEmX domain on membrane-bound IgE (mlgE) expressed on the surface of human B lymphocytes. The CEmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mlgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP peptide at the C-terminal of CEmX, have now been found to bind poorly to mlgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL and HSGQQQGLPRAAGGSVPHPR, of CEmX can bind effectively to mlgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

公开(公告)号：CA2960712A1

公开(公告)日：2016-03-17

申请号：CA2960712

申请日：2015-09-08

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

IPC: C07H15/18 ,  A61K39/39

Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.

公开(公告)号：CA2956808A1

公开(公告)日：2016-02-04

申请号：CA2956808

申请日：2015-07-31

Applicant: ACADEMIA SINICA ,  UNIV NAT TAIWAN ,  UNIV TAIPEI MEDICAL

Inventor： PECK KONAN ,  YANG PAN-CHYR ,  CHANG YI-CHUNG ,  HUANG BO-TSANG ,  YEH SHAUH-DER

IPC: C12N15/115 ,  A61K31/711 ,  A61P35/00 ,  A61P37/00

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

公开(公告)号：CA2956718A1

公开(公告)日：2016-02-04

申请号：CA2956718

申请日：2015-07-31

Applicant: ACADEMIA SINICA ,  UNIV NAT TAIWAN

Inventor： YANG PAN-CHYR ,  CHANG YI-CHUNG ,  LAI WEI-YUN

IPC: C12N15/115 ,  A61K31/7088 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C12N15/113

Abstract: Aptamers that bind to and antagonize PD-1 and uses thereof in promoting T cell proliferation, treating cancer or infectious diseases such as HIV infection.

公开(公告)号：CA2955214A1

公开(公告)日：2016-01-28

申请号：CA2955214

申请日：2015-07-23

Applicant: ACADEMIA SINICA ,  CHEN YUAN-TSONG

Inventor： CHEN YUAN-TSONG ,  WU JER-YUARN ,  KO TAI-MING ,  KUO HO-CHANG ,  CHANG JENG-SHENG

IPC: G01N33/53 ,  A61K39/395 ,  A61P9/00 ,  A61P29/00

Abstract: Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off level. Also described is a kit for carrying out the method.

公开(公告)号：CA2949381A1

公开(公告)日：2015-11-19

申请号：CA2949381

申请日：2015-05-16

Applicant: ACADEMIA SINICA ,  LI WEN-HSIUNG

Inventor： LI WEN-HSIUNG ,  CHANG JUI-JEN ,  THIA CAROLINE ,  LIN HAO-YEH ,  LIN YU-JU ,  HUANG CHIEH-CHEN

IPC: C12N1/13 ,  C12N15/16 ,  C12N15/21 ,  C12N15/27 ,  C12N15/52 ,  C12N15/82 ,  G06F9/455

Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.

公开(公告)号：ES2545969T3

公开(公告)日：2015-09-17

申请号：ES09795269

申请日：2009-07-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG EDMOND Y S ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

IPC: C07H15/18 ,  A61K31/70 ,  A61K31/7034 ,  A61K39/00 ,  A61K39/39 ,  A61P31/04 ,  A61P31/16 ,  A61P35/00

Abstract: Un compuesto representado por la estructura de fórmula 1:**Fórmula** o una sal farmacéuticamente aceptable del mismo; para su uso en medicina.

公开(公告)号：CA2931045A1

公开(公告)日：2015-06-18

申请号：CA2931045

申请日：2014-12-10

Applicant: UNIV WIEN TECH ,  UNIV OREGON STATE ,  ACADEMIA SINICA

Inventor： SCHMOLL MONIKA ,  TISCH DORIS ,  SCHUSTER ANDRE ,  FREITAG MICHAEL ,  POMRANING KYLE ,  WANG TING FANG

IPC: C12N1/14 ,  C07K14/37 ,  C12P21/02

Abstract: The present invention relates to a female fertile variant strain of filamentous fungus derived from a female sterile parental strain which comprises at least one of the six female fertility specific gene alleles or derivatives thereof comprising the functional characteristics of these alleles (FS_4-9).

公开(公告)号：CA2927699A1

公开(公告)日：2015-04-30

申请号：CA2927699

申请日：2014-10-22

Applicant: ACADEMIA SINICA

Inventor： FANG JIM-MIN ,  LIN YUN-LIAN ,  LIN JUNG-HSIN ,  LIN CHUN-JUNG ,  CHERN YIJUANG ,  HUANG NAI-KUEI ,  WANG HUNG-LI ,  TU BENJAMIN PANG-HSIEN ,  CHEN CHIH-CHENG

IPC: C07D498/02 ,  A61K31/7076 ,  A61P25/28 ,  A61P29/00

Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N 6 -[(3-halothien-2-yl)methyl]adenosine, N 6 -[(4-halothien-2-yl)methyl]adenosine, and N 6 -[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N 6 -[(2-bromothien-3-yl)methyl]adenosine, N 6 -[(4-bromothien-3-yl)methyl]adenosine, N 6 -[(5-bromothien-3-yl)methyl]adenosine N 6 -[(2-chlorothien-3-yl)methyl]adenosine, N 6 -[(4-chlorothien-3-yl)methyl]adenosine, and N 6 -[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.

公开(公告)号：IN951MUN2014A

公开(公告)日：2015-04-24

申请号：IN951MUN2014

申请日：2014-05-20

Applicant: ACADEMIA SINICA

Inventor： YANG WEN CHIN ,  CHANG LEE TIAN

IPC: A61K36/00 ,  A01N25/08 ,  A23K20/195

Abstract: A composition for use in prevention inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa an active constituent thereof or an active compound isolated therefrom. In another aspect a composition for use in preventing and/or treating coccidiosis and/or enhancing growth in an animal is disclosed the composition comprising an animal feed and an effective amount of Bidens pilosa or an isolated active constituent comprising a polyacetylenic compound.